A Study Evaluating Safety, Pharmacokinetics, and Therapeutic Activity of RO6874281 as a Single Agent (Part A) or in Combination With Trastuzumab or Cetuximab (Part B or C)

PHASE1CompletedINTERVENTIONAL
Enrollment

134

Participants

Timeline

Start Date

December 7, 2015

Primary Completion Date

November 10, 2022

Study Completion Date

November 10, 2022

Conditions
Solid TumorBreast CancerCancer of Head and Neck
Interventions
DRUG

RO6874281

RO6874281 will be administered as per the schedule specified under arm description.

DRUG

Trastuzumab

Trastuzumab will be administered as per the schedule specified under arm description.

DRUG

Cetuximab

Cetuximab will be administered as per the schedule specified under arm description.

Trial Locations (26)

2100

Rigshospitalet; Onkologisk Klinik, København Ø

2650

UZ Antwerpen, Edegem

20133

Fondazione IRCCS Istituto Nazionale dei Tumori;S.S. Trattamento MedicoTumori dellaTesta e delCollo, Milan

20141

Istituto Europeo di Oncologia; Svil. Nuovi Farmaci per Terapie Innovative, Milan

20162

Azienda Socio Sanitaria Territoriale Niguarda (Ospedale Niguarda Ca' Granda); Oncologico -Onc.Falck, Milan

21000

Centre Georges Francois Leclerc, Dijon

27100

Ospedale Policlinico S. Matteo; Phase I Clinical Trial Unit and Experimental Therapy, Pavia

31008

Clinica Universitaria de Navarra, Pamplona

31059

Institut Claudius Regaud; Departement Oncologie Medicale, Toulouse

33076

Institut Bergonie; Oncologie, Bordeaux

43210

The Ohio State University, Columbus

47014

IRST Istituto Scientifico Romagnolo Per Lo Studio E Cura Dei Tumori, Sede Meldola; Oncologia Medica, Meldola

63110

Washington University; Division of Oncology, St Louis

69008

Centre Leon Berard, Lyon

85234

Banner MD Anderson Cancer Center, Greeley

85719

University of Arizona Cancer Center, Tucson

92037

UCSD - Moores Cancer Center, La Jolla

94805

Institut Gustave Roussy; Sitep, Villejuif

L8V 5C2

Juravinski Cancer Clinic; Department of Oncology, Hamilton

M5G 1Z5

Princess Margaret Cancer Center, Toronto

1066 CX

Antoni Van Leeuwenhoek Ziekenhuis; Gastro-Enterologie, Amsterdam

3015 GD

Erasmus MC, Rotterdam

08035

Hospital Univ Vall d'Hebron; Servicio de Oncologia, Barcelona

LE1 5WW

Leicester Royal Infirmary, Leicester

SE1 9RT

Guys and St Thomas NHS Foundation Trust, Guys Hospital, London

M20 3BG

Christie Hospital, Manchester

All Listed Sponsors
lead

Hoffmann-La Roche

INDUSTRY

NCT02627274 - A Study Evaluating Safety, Pharmacokinetics, and Therapeutic Activity of RO6874281 as a Single Agent (Part A) or in Combination With Trastuzumab or Cetuximab (Part B or C) | Biotech Hunter | Biotech Hunter