Treatment of Impulsive Aggression in Subjects With ADHD in Conjunction With Standard ADHD Treatment (CHIME 1)

PHASE3CompletedINTERVENTIONAL
Enrollment

333

Participants

Timeline

Start Date

January 25, 2016

Primary Completion Date

September 4, 2019

Study Completion Date

October 24, 2019

Conditions
Attention Deficit Hyperactivity Disorder (ADHD)
Interventions
DRUG

SPN-810 (18 mg)

Subjects were randomized to receive SPN-810 low dose (18 mg) twice each day (BID) with or without food, in the morning and in the evening, in addition to the stable dose of the optimized ADHD medication determined from the lead-in period. If initiating treatment before noon, patients should start with the morning dose; if after noon, the evening dose.

DRUG

SPN-810 (36 mg)

Subjects were randomized to receive SPN-810 high dose (36 mg) twice each day (BID) with or without food, in the morning and in the evening, in addition to the stable dose of the optimized ADHD medication determined from the lead-in period. If initiating treatment before noon, patients should start with the morning dose; if after noon, the evening dose.

DRUG

Placebo

Subjects were randomized to receive Placebo twice each day (BID) with or without food, in the morning and in the evening, in addition to the stable dose of the optimized ADHD medication determined from the lead-in period. If initiating treatment before noon, patients should start with the morning dose; if after noon, the evening dose.

Trial Locations (28)

14618

Finger Lakes Clinical Research, Rochester

21205

Hugo W Moser Research Institute at Kennedy Krieger, Baltimore

23230

Alliance Research Group, LLC., Richmond

29407

Carolina Clinical Trials, Inc., Charleston

32607

Sarkis Clinical Trials, Gainesville

32751

Florida Clinical Research Center, LLC., Maitland

32801

CNS Healthcare of Orlando, Orlando

34201

Meridien Research at Florida Clinical Research Center, Bradenton

38119

CNS Healthcare, Memphis

Research Strategies of Memphis, LLC, Memphis

43210

Ohio State University Nisonger Center Clinical Trials Program, Columbus

60048

Capstone Clinical Research, Libertyville

60617

American Medical Research, Chicago

66211

Psychiatric Associates, Overland Park

72758

Woodland Research Northwest, Rogers

73112

Oklahoma Clinical Research Center, Oklahoma City

73118

Paradigm Research Professionals, Oklahoma City

75243

Relaro Medical Trials, Dallas

77006

Bayou City Research Corporation, Houston

77381

Family Psychiatry of the Woodlands, The Woodlands

78229

Clinical Trials of Texas, Inc., San Antonio

78258

Road Runner Research, San Antonio

84058

Aspen Clinical Research, Orem

90230

ProScience, Culver City

91206

Behavioral Research Specialists, Glendale

92868

Neuropsychiatric Research Center of Orange County, Orange

97030

Cyn3rgy Research, Gresham

98121

Seattle Children's Research Institute, Seattle

All Listed Sponsors
lead

Supernus Pharmaceuticals, Inc.

INDUSTRY

NCT02618408 - Treatment of Impulsive Aggression in Subjects With ADHD in Conjunction With Standard ADHD Treatment (CHIME 1) | Biotech Hunter | Biotech Hunter