Switching From a Tenofovir Disoproxil Fumarate (TDF) Containing Regimen to Elvitegravir/Cobicistat/Emtricitabine/ Tenofovir Alafenamide (E/C/F/TAF) Fixed-Dose Combination (FDC) in Virologically-Suppressed, HIV-1 Infected Adults Aged ≥ 60 Years

PHASE3CompletedINTERVENTIONAL
Enrollment

167

Participants

Timeline

Start Date

December 22, 2015

Primary Completion Date

February 21, 2018

Study Completion Date

March 21, 2018

Conditions
HIV-1 Infection
Interventions
DRUG

E/C/F/TAF

150/150/200/10 mg FDC tablet administered orally once daily

DRUG

TDF

300 mg tablet administered orally once daily

DRUG

FTC

200 mg capsule administered orally once daily

DRUG

FTC/TDF

200/300 mg tablet administered orally once daily

DRUG

3TC

Tablet administered orally

DRUG

Third agent

"Third agent may include one of the following regimens: lopinavir+ritonavir (LPV/r; Kaletra®), atazanavir (ATV; Reyataz®) + ritonavir (RTV; Norvir®), ATV + cobicistat (COBI;Tybost®) (or ATV/COBI FDC), DRV + RTV, darunavir (DRV; Prezista®) + COBI (or DRV/COBI FDC), fosamprenavir (FPV; Lexiva®) + RTV , saquinavir (SQV; Invirase®; Fortovase®) + RTV, efavirenz (EFV;Sustiva®), rilpivirine (RPV;Edurant®), nevirapine (NVP;Viramune®), etravirine (ETR;Intelence®), raltegravir (RAL; Isentress®), elvitegravir (EVG) + COBI, or dolutegravir (DTG;Tivicay®)~Drug classes:~* Protease inhibitors (PI): LPV/r, ATV, RTV, ATV, DRV, FPV, and SQV~* Pharmacokinetic enhancer: COBI~* Non-nucleoside reverse transcriptase inhibitors (NNRTI): EFV, RPV, NVP, and ETR~* Integrase inhibitors: RAL and DTG"

Trial Locations (35)

Unknown

CHU Saint-Pierre University Hospital, Brussels

University Hospital Gent, Ghent

CHU - Groupe Saint-Andre, Bordeaux

CHU de Dijon, Dijon

Hopital Europeen Marseille, Marseille

C.H.U. de Nantes, Nantes

C.H.U. de NICE, Nice

CHU Hotel Dieu, Paris

Hopital Necker les Enfants Malades, Paris

Hopital Saint Antoine, Paris

Hopital Saint Louis, Paris

Hopital Haut-Leveque, Pessac

Service des Maladies Infectieuses et du Voyageur, Tourcoing

Azienda Ospedaliera Papa Giovanni XXIII, Bergamo

Busto Arsizio Hospital, Busto Arsizio

IRCCS A.O.U. San Martino, Genova

Azienda Ospedaliera Luigi Sacco, Milan

Azienda Ospedaliero Universitaria Policlinico di Modena, Modena

U.O. Malattie Infettive, Pescara

Istituto Nazionale Malattie Infettive Lazzaro Spallanzani I.R.C.C.S., Roma

Azienda Ospedaliero Universitaria di Sassari, Sassari

Dipartimento di Malattie Infettive e Tropicali, Torino

Hospital Clinic de Barcelona, Barcelona

Hospital de la Santa Creu i Sant Pau, Barcelona

Hospital Universitari Germans Trias i Pujol, Barcelona

Hospital Vall d'Hebron, Barcelona

Hospital 12 de Octubre, Madrid

Hospital General Universitario Gregorio Maranon, Madrid

Hospital Universitario La Paz, Madrid

Ramon Y Cajal University Hospital, Madrid

Hospital Costa Del Sol, Marbella

Hospital General Universitario de Valencia, Valencia

Royal Victoria Hospital, Belfast

Mortimer Market Centre, London

Newcastle Royal Victoria Infirmary, Newcastle upon Tyne

Sponsors

Lead Sponsor

All Listed Sponsors
lead

Gilead Sciences

INDUSTRY