133
Participants
Start Date
March 9, 2016
Primary Completion Date
August 4, 2022
Study Completion Date
August 4, 2022
Obinutuzumab
Participants will receive a fixed dose of obinutuzumab, 1000 milligrams (mg) via intravenous (IV) infusion to be given on Days 1, 8 and 15 of Cycle 1 and on Day 1 of Cycles 2 to 6. Cycle length will be 21 days. For eligible participants, post-induction treatment may be given at a dose of 1000 mg via IV infusion on Day 1 of every other month (starting from Month 2) for up to 24 months, until disease progression or unacceptable toxicity.
Rituximab
Participants will receive a fixed dose of rituximab, 375 milligrams per square meter (mg/m\^2) via IV infusion to be given on Day 1 of Cycles 1 to 6. Cycle length will be 21 days. For eligible participants, post-induction treatment may be given at a dose of 375 mg/m\^2 via IV infusion on Day 1 of every other month (starting from Month 2) for up to 8 months, until disease progression or unacceptable toxicity.
Polatuzumab Vedotin
Participants will receive polatuzumab vedotin via IV infusion at doses of 1.4 or 1.8 milligrams per kilogram (mg/kg) (for FL), and 1.8 mg/kg (for DLBCL) on Day 1 of each 21-day cycle for up to 18 weeks during induction treatment. Polatuzumab vedotin will not be given during the post-induction period.
Venetoclax
Participants will receive venetoclax film-coated tablets at doses of 200, 400, 600, or 800 mg (for FL), and 400, 600, or 800 mg (for DLBCL) on Days 1 to 21 of each 21-day cycle. Post-induction venetoclax may continue for up to 8 months, until disease progression or unacceptable toxicity.
Royal North Shore Hospital; Haematology Department, St Leonards
Calvary Mater Newcastle, Waratah
Peter MacCallum Cancer Center, North Melbourne
Princess Alexandra Hospital, Woolloongabba
The Queen Elizabeth Hospital, Adelaide
Royal Hobart Hospital, Hobart
A.O.U. Citta' Della Salute E Della Scienza-P.O. Molinette;S.C. Ematologia, Turin
Roswell Park Cancer Inst., Buffalo
Fox Chase Cancer Center, Philadelphia
Fondazione IRCCS Istituto Nazionale dei Tumori, Milan
Papa Giovanni Hospital XXIII, Bergamo
SCDU Ematologia, Novara
Emory Univ Winship Cancer Inst, Atlanta
Memorial Healthcare System, Pembroke
University of Louisville Hospital; The James Graham Brown Cancer Center, Louisville
Istituto Scientifico Romagnolo Per Lo Studio e La Cura Dei Tumori, Meldola
Ospedale Infermi U.O. Ematologia, Rimini
UO Ematologia, Ospedale S.Maria delle Croci, Ravenna
Scott and White, Temple
University of Arizona Cancer Center, Tucson
Yale Cancer Center, New Haven
University of Michigan, Ann Arbor
Rutgers Cancer Institute of New Jersey, New Brunswick
Hoffmann-La Roche
INDUSTRY