2,000
Participants
Start Date
March 10, 2016
Primary Completion Date
April 30, 2030
Study Completion Date
April 30, 2030
Cognitive Assessment
-Baseline and no more frequently than every 6 months until death
Activities of Daily Living Questionnaire
"* 10 items about daily functional status~* Baseline and no more frequently than every 6 months until death"
Instrumental Activities of Daily Living, subscale of the OARS
"* 7 items about daily functional status~* Baseline and no more frequently than every 6 months until death"
Karnofsky Self-reported Performance Rating Scale
"* 1 item about daily functional status~* Baseline and no more frequently than every 6 months until death"
Number of Falls
"* 1 item about daily functional status~* Baseline and no more frequently than every 6 months until death"
Physical Health Section, subscale of the OARS
"* 13 items about comorbidity~* Baseline and no more frequently than every 6 months until death"
MOS Social Activity Survey
"* 4 items about social activity~* Baseline and no more frequently than every 6 months until death"
Unintentional Weight Loss
"* 2 items about nutrition~* Baseline and no more frequently than every 6 months until death"
Peripheral Blood Draw
-Baseline and no more frequently than every 6 months until death
Buccal Swab
"* Participants will rinse their mouths 2 times with water for 20-30 seconds and discard the expectorated sample. One side of the inner cheek (buccal mucosa) will then be scraped with a cotton swab 20 times (alternatively, the tongue will be brushed 20 times with a toothbrush)~* Baseline and no more frequently than every 6 months until death"
Heart Health and Smoking History from BRFSS questionnaire
"* 7 items about heart health and smoking history~* Baseline and no more frequently than every 6 months until death"
Gait Speed
"* Research coordinator will test gait speed~* Baseline and no more frequently than every 6 months until death"
Grip Strength
"* Research coordinator will test grip strength~* Baseline and no more frequently than every 6 months until death"
Height and Weight measurements
-Baseline and no more frequently than every 6 months until death
Blood pressure measurement
-Baseline and no more frequently than every 6 months until death
Optional bone marrow biopsy
-1 optional bone marrow biopsy
Blood draw for trauma measurements
-For Arm E only
RECRUITING
Washington University School of Medicine, St Louis
Edward P. Evans Foundation
OTHER
Washington University School of Medicine
OTHER