Alectinib Versus Pemetrexed or Docetaxel in Anaplastic Lymphoma Kinase (ALK)-Positive Advanced Non-Small Cell Lung Cancer (NSCLC) Participants Previously Treated With Platinum-Based Chemotherapy and Crizotinib

PHASE3CompletedINTERVENTIONAL
Enrollment

119

Participants

Timeline

Start Date

November 3, 2015

Primary Completion Date

January 26, 2017

Study Completion Date

August 13, 2018

Conditions
Non-small Cell Lung Cancer
Interventions
DRUG

Alectinib

Participants will receive oral alectinib at a dose of 600 mg twice daily, taken with food until disease progression, unacceptable toxicity, withdrawal of consent or death.

DRUG

Docetaxel

Participants will receive docetaxel at a dose of 75 mg/m\^2 of body surface area intravenously every 3 weeks, until disease progression, unacceptable toxicity, withdrawal of consent or death.

DRUG

Pemetrexed

Participants will receive pemetrexed at a dose of 500 mg/m\^2 of body surface area intravenously every 3 weeks, until disease progression, unacceptable toxicity, withdrawal of consent or death.

Trial Locations (54)

1083

Semmelweis Egyetem X; Pulmonologiai Klinika, Budapest

1632

MBAL Serdika EOOD, Sofia

2650

UZ Antwerpen, Edegem

6000

GHdC Site Notre Dame, Charleroi

9000

UZ Gent, Ghent

13125

Evang. Lungenklinik Berlin Klinik für Pneumologie, Berlin

14076

Centre Francois Baclesse, Caen

20132

Irccs Ospedale San Raffaele;Oncologia Medica, Milan

20141

Irccs Istituto Europeo Di Oncologia (IEO); Oncologia Medica, Milan

26121

Pius-Hospital; Klinik fuer Haematologie und Onkologie, Oldenburg

28046

Hospital Universitario La Paz; Servicio de Oncologia, Madrid

28850

Hospital Universitario de Torrejon, Torrejón de Ardoz

29010

Hospital Clinico Universitario Virgen de la Victoria; Servicio de Oncologia, Málaga

31059

Hopital Larrey; Pneumologie, Toulouse

33600

Hopital Du Haut Leveque; Service Des Maladies Respiratoires, Pessac

34093

Istanbul Uni Capa Medical Faculty; Inst. of Oncology, Istanbul

34376

Fachklinik für Lungenerkrankungen, Immenhausen

35040

Ege University Medical Faculty; Chest Diseases, Izmir

44280

Inonu University Medical Faculty Turgut Ozal Medical Center Medical Oncology Department, Malatya

46026

Hospital Universitari i Politecnic La Fe de Valencia, Valencia

48100

Ospedale Provinciale Santa Maria Delle Croci; Oncologia Medica, Ravenna

48903

Hospital de Cruces; Servicio de Oncologia, Bilbao

56124

A.O. Universitaria Pisana-Ospedale Cisanello; Dipartimento Cardio Toracico-Pneumologia Ii, Pisa

57070

Hopital Robert Schuman; Pneumologie, Vantoux

58128

Chonnam National University Hwasun Hospital, Jeollanam-do

75877

Hopital Bichat Claude Bernard ; Service de Pneumologie, Paris

80131

AORN Ospedali dei Colli Ospedale Monaldi; UOC Pneumologia ad indirizzo Oncologico, Napoli

Istituto Nazionale Tumori Fondazione G. Pascale; U.O.C. Oncologia Medica Toraco Polmonare, Napoli

82131

Asklepios-Fachkliniken Muenchen-Gauting; Onkologie, Gauting

83056

Hopital Sainte Musse; Pneumologie, Toulon

83100

Azienda Ospedaliera di Rilievo Nazionale e di Alta Specialita San Giuseppe Moscati, Avellino

92151

Hopital Foch; Pneumologie, Suresnes

95100

POLICLINICO RODOLICO, U.O. di Oncologia Medica, Catania

99437

Zentralklinik Bad Berka GmbH; Abteilung Onkologie und Hämatologie, Bad Berka

105229

Main Military Clinical Hospital named after N.N. Burdenko, Moscow

121467

University сlinic of headaches, Moscow

143423

City Clinical Oncology Hospital, Moscow

197022

City Clinical Oncology Dispensary, Saint Petersburg

197758

"FSBINational Medical Research Center of Oncology named after N.N.Petrov MHRF", Saint Petersburg

S-Pb clinical scientific practical center of specialized kinds of medical care (oncological), Saint Petersburg

Unknown

Queen Elizabeth Hospital; Clinical Oncology, Hong Kong

Queen Mary Hospital; Dept. of Clinical Oncology, Hong Kong

00152

Azienda Ospedaliera San Camillo Forlanini; U.O.C. Pneumologia Ad Indirizzo Oncologico 1, Rome

06156

Azienda Ospedaliera Di Perugia Ospedale s. Maria Della Misericordia; Oncologia Medica, Perugia

0310

Oslo Universitetssykehus HF; Radiumhospitalet, Oslo

80-952

Medical University of Gdansk, Gdansk

3041-801

Hospital Geral; Servico de Pneumologia, Coimbra

4200-072

IPO do Porto; Servico de Oncologia Medica, Porto

4434-502

CHVNG/E_Unidade 1; Servico de Pneumologia, Vila Nova de Gaia

975 17

FNsP F. D. Roosevelta Banska Bystrica, II.Ocna klinika SZU, Banská Bystrica

040 01

Vychodoslovensky onkologicky ustav, Košice

152-703

Korea University Guro Hospital; Oncology, Seoul

01130

Adana Acıbadem Hospital Oncology Department, Adana

06100

Hacettepe Uni Medical Faculty Hospital; Oncology Dept, Ankara

All Listed Sponsors
lead

Hoffmann-La Roche

INDUSTRY

NCT02604342 - Alectinib Versus Pemetrexed or Docetaxel in Anaplastic Lymphoma Kinase (ALK)-Positive Advanced Non-Small Cell Lung Cancer (NSCLC) Participants Previously Treated With Platinum-Based Chemotherapy and Crizotinib | Biotech Hunter | Biotech Hunter