700
Participants
Start Date
April 25, 2016
Primary Completion Date
October 21, 2019
Study Completion Date
March 28, 2023
Avelumab
1 hour intravenous infusion every 2 weeks (Q2W) in 4 week cycles
Best Supportive Care
BSC will be administered as deemed appropriate by the treating physician, and could include treatment with antibiotics, nutritional support, correction of metabolic disorders, optimal symptom control and pain management (including palliative radiotherapy), etc. BSC does not include any active anti-tumor therapy, however local radiotherapy of isolated lesions with palliative intent is acceptable.
Following the planned interim analysis for this study: Avelumab
1 hour intravenous infusion every 2 weeks (Q2W) in 4 week cycles
Investigational Drug services, National Taiwan University Hospital, Taipei
National Taiwan University Hospital, Taipei
Koo Foundation Sun Yat-Sen Cancer Center, Taipei
Pharmacy, Koo Foundation Sun Yat-Sen Cancer Center, Taipei
Chang Gung Memorial Hospital, Linkou, Taoyuan District
Chemotherapy pharmacy, Chang Gung Memorial Hospital, Linkou, Taoyuan District
China Medical University Hospital, Taichung
Department of Pharmacy, National Cheng Kung University Hospital, Tainan City
National Cheng Kung University Hospital, Tainan City
Auckland City Hospital Pharmacy, Grafton
Slade Health Inward Goods, Auckalnd
Hôpital Erasme, Brussels
Auckland City Hospital, Grafton
Sykehusapoteket HF 23 Lørenskog, Nordbyhagen
Sykehusapoteket Lorenskog, Nordbyhagen
Akershus University Hospital, Lorenskog
Sykehusapoteket HF 23 Lørenskog, Lorenskog
Bildediagnostisk avdeling, Nordbyhagen
Chris O'Brien Lifehouse, Camperdown
Rigshospitalet, Onkologisk Klinik, afsnit 5073, Copenhagen OE
Klinik for Klinisk Fysiologi,Nuklearmedicin og PET, København Ø
Rigshospitalet, København Ø
Macquarie Medical Imaging, Macquarie University
Macquarie University Hospital Pharmacy, Macquarie University
Macquarie University, Macquarie University
Macquarie Heart, New South Wales
Concord Hospital, Concord
Ramsay Pharmacy, Kogarah
St George Private Hospital, Kogarah
Epic Pharmacy, Lismore
North Coast Radiology St Vincents, Lismore
Northern Rivers Pathology Service, Lismore
St Vincent's Pathology Lismore, Lismore
The Murwillumbah Hospital, Murwillubah
The Tweed Hospital Pharmacy Department, Tweed Heads
The Tweed Hospital, Tweed Heads
GZA Sint-Augustinus, Wilrijk
Herlev Hospital, Herlev
Herlev og Gentofte Hospital, Herlev
Dubbo Base Hospital, Dubbo
AZ Klina - Apotheek, Brasschaat
AZ Klina, Brasschaat
Box Hill Hospital - Pharmacy Department, Bulding B, Loading Dock (access via Thames St), Box Hill
Box Hill Hospital, Box Hill
Eastern Health Clinical School, Box Hill
Slade Health, Mount Waverley
Monash Medical Centre, East Bentleigh
Moorabbin Radiology, East Bentleigh
Monash Medical Centre, Clayton
Waikato Hospital, Hamilton
BHS Diagnostic Services, Ballarat
Lake Imaging, Ballarat
Ballarat Oncology & Haematology Services, Ballarat
Ballarat Day Procedure Centre, Wendouree
Ballarat Oncology & Haematology Services, Wendouree
Nova Pharmacy, Wendouree
CHU de Liège, Liège
Stavanger University Hospital, Stavanger
Icon Cancer Care Chermside, Chermside
Slade Health, Geebung
Icon Cancer Care Wesley, Auchenflower
River City Pharmacy, Auchenflower
Icon Cancer Care South Brisbane, South Brisbane
Icon Cancer Care, South Brisbane
Integrated Clinical Oncology Network (ICON) Corporate Office, South Brisbane
Icon Cancer Care Southport, Southport
Oncology Pharmacy, Birtinya
Sunshine Coast University Hospital, Birtinya
Hospital Clinico Universitario de Valencia, Valencia
The Townsville Hospital, Douglas
Odense Universitetshospital, Odense
Odense Universitetshospital, Odense C
The Queen Elizabeth Hospital, Woodville South
Adelaide Cancer Centre, Kurralta Park
Ashford Cancer Centre Research, Kurralta Park
Cancer Care SA Pty Ltd, Kurralta Park
Icon Cancer Care SA trading as Icon Pharmacy Adelaide, Kurralta Park
Flinders Medical Centre, Bedford Park
SA Pharmacy, Level 3 Pharmacy, Bedford Park
GP Diagnostico SRL, La Rioja
Hospital Regional Dr. Enrique Vera Barros, La Rioja
Instituto del Diagnostico, La Rioja
Fiona Stanley Hospital, Murdoch
St John of God Murdoch Hospital, Murdoch
Kaposvári Egyetem Egészségügyi Centrum, Kaposvár
Somogy Megyei Kaposi Mór Oktató Kórház, Kaposvár
Aarhus Universitetshospital, Aarhus C
Christchurch Hospital, Christchurch
Aarhus Universitetshospital, Aarhus N
CT-Klinikken A/S, Aarhus N
AZ Groeninge, Kortrijk
UZ Gent, Ghent
Aalborg Universitetshospital Syd, Aalborg
Aalborg Universitetshospital, Aalborg
Sygehusapoteket Aalborg, Aalborg
Farmacia Ospedaliera, Candiolo
Fondazione del Piemonte per l'Oncologia - IRCCS Candiolo, Candiolo
National Cancer Center - Clinical Trial Pharmacy, Goyang-si
National Cancer Center Urology center for Prostate Cancer, Goyang-si
Institute for Oncology and Radiology of Serbia, Belgrade
Sotiria General Chest Disease Hospital, Athens
Alexandra General Hospital, Oncology Department, Athens
Metropolitan General Hospital, Athens
Institut Paoli Calmettes, Marseille
Institut Paoli Calmettes, Marseille
Hopital La Conception, Marseille
Hopital de La Timone, Marseille
Seoul National University Bundang Hospital, Clinical Pharmacy, Seongnam-si
Seoul National University Bundang Hospital, Seongnam-si
Hospital Universitario Reina Sofia, Córdoba
Hospital Universitario Reina Sofía, Córdoba
Instituto Nacional de Cancerologia, Mexico City
Medical Center of Athens, Marousi
C.H. Univ. Santiago de Compostela, Santiago de Compostela
U.O.C. Farmacia, Genova
IRCCS Ospedale Policlinico San Martino, Genoa
H. univ Girona Dr. Josep Trueta - lnstitut Catala d'Oncologia, Girona
Institut Catala d'Oncologia, Girona
Institut Diagnostic de la lmatge, Girona
Clinical Centre Nis, Clinic of Oncology, Niš
Farmacia Studi Clinici, Rozzano
Istituto Clinico Humanitas, Rozzano
Fondazione IRCCS Istituto Nazionale Dei Tumori, Milan
SC Farmacia, Milan
Instituto Europeo di Oncologia, Milan
Servizio di Farmacia, Milan
Oncology Institute of Vojvodina, Kamenitz
Inova Schar Cancer Institute Infusion Pharmacy, Fairfax
Inova Schar Cancer Institute, Fairfax
CHU Besançon - Pharmacie Unite Essais cliniques, Besançon
CHU Besançon, Besançon
Hôpital Jean Minjoz, Besançon
University General Hospital of Patras, Division of Oncology, Pátrai
Hospital Universitario Lucus Augusti, Lugo
Fundacion Maria Rafols para la investigacion del Diagnostico de la imagen, Madrid
Gabinete Radiologico Doctor Pita, Madrid
Hospital General Universitario Gregorio Marañon, Madrid
Hospital Ruber Internacional, Madrid
Hospital Ruber International, Madrid
Hospital Universitario Ramón y Cajal, Madrid
Hospital Clinico San Carlos, Madrid
Hospital Clínico San Carlos, Madrid
Hospital Universitario 12 de Octubre, Madrid
Hospital Universitario La Paz, Madrid
Hospital Universitario HM Sanchinarro - CIOCC, Madrid
Hospital Universitario Infanta Sofia, San Sebastián de los Reyes
CHU Nimes - Hopital Caremeau, Nîmes
CHU Nimes - Institut de Cancerologie du Gard, Nîmes
CHU Nimes, Nîmes
C. H. Universitario de Vigo- Hospital Álvaro Cunqueiro, Vigo
Clinica Universidad de Navarra, Pamplona
Complejo Hospitalario de Navarra, Pamplona
Rambam Health Care Campus, Haifa
Hospital Universitario Central de Asturias, Oviedo
Centro di Riferimento Oncologico - IRCCS, Aviano (PN)
S.O.C. di Farmacia, Aviano (PN)
Chungnam National University Hospital, Clinical Pharmacy, Daejeon
Chungnam National University Hospital, Daejeon
Centre Eugene Marquis, Rennes
C. H. Universitario de Vigo- Hospital Álvaro Cunqueiro, Vigo
C.H. Universitario de Vigo- Hospital Meixoeiro, Vigo
Hospital Médica Campestre (Administradora Hospitalaria S.A de C.V.), León
Centro de Investigación Clínica de Leon S.C., León
Azienda Ospedaliero-Universitaria Policlinico S.Orsola Malpighi, Bologna
U.O. Farmacia Clinica - IDS, Bologna
Clinical Trial Pharmacy, China Medical University Hospital, Taichung
Hospital Universitario Virgen del Rocio, Seville
Cleveland Clinic Taussing Cancer Center, Cleveland
Cleveland Clinic Taussing Cancer Center, Cleveland
Cleveland Clinic Foundation, Cleveland
Cleveland Clinic Taussing Cancer Center, Cleveland
Institut de Cancérologie de l'Ouest - Centre René Gauducheau, Saint-Herblain
Instituto Valenciano de Oncología, Valencia
Hospital Clinico Universitario de Valencia, Valencia
Hospital Clínico Universitario de Valencia, Valencia
Farmacia Oncologica, Meldola
"IRCCS - Istituto Romagnolo per lo Studio dei Tumori (IRST) Dino Amadori", Meldola
U.O. Anatomia Patologica, Forlì
U.O. Radiologia, Forlì
U.O.S. Medicina Nucleare, Forlì
AUSL della Romagna - RAVENNA, Presidio Ospedaliero di Faenza, Faenza
Presidio Ospedaliero di Lugo, Lugo
Presidio Ospedaliero di Ravenna, Ravenna
Servizio Farmacia Ospedaliera - Farmacia Oncologica, Ravenna
Institut de cancérologie de l'Ouest - Site Paul Papin, Angers
Institut de cancérologie de l'Ouest - Site Paul Papin, Angers
Farmacia Ospedaliera, Arezzo
Presidio Ospedaliero San Donato, Arezzo
Phylasis Clinicas Research S. de R.L. de C.V., Cuautitlán Izcalli
University of Minnesota Medical Center, Minneapolis
University of Minnesota, Minneapolis
A.O.U. Pisana Ospedale S. Chiara, Pisa
Centre Oscar Lambret, Lille
Centre Oscar Lambret, Lille
AOU Ospedali Riuniti di Ancona, Torrette
Centre d'Oncologie et de Radiothérapie du Pays-Basque, Bayonne
Clinique CAPIO Belharra, Bayonne
Centre de Radiothérapie - Clinique Sainte Anne, Strasbourg
Clinique Sainte Anne, Strasbourg
Centre Leon Berard, Lyon
Centre Léon Berard, Lyon
Assaf Harofe MC, Beer Yaakov
Clinique Victor Hugo, Le Mans
Groupe Hospitalier Pitié Salpêtrière, Paris
Groupe hospitalier Pitie Saleptriere, Paris
Groupe Hospitalier Pitié Salpêtrière, Paris
CHU de Rouen - Hôpital Charles Nicolle, Rouen
CHU de Rouen, Rouen
Centre Henri Becquerel, Rouen
Anschutz Cancer Center Pavilion Pharmacy, Aurora
University of Colorado Cancer Center, Aurora
University of Colorado Denver, CTO (CTRC), Aurora
University of Colorado Hospital - Anschutz Inpatient Pavilion (AIP), Aurora
University of Colorado Hospital - Anschutz Outpatient Pavilion (AOP), Aurora
"Azienda Ospedaliera di Rilievo Nazionale A. Cardarelli", Naples
UOSC Farmacia, Naples
Istituto Nazionale per lo Studio e la Cura dei Tumori, IRCCS Fondazione Giovanni Pascale, Napoli
S.C. Farmacia Ospedaliera, Napoli
Hôpital Privé Toulon-Hyères - Clinique Sainte Marguerite, Hyères
Hadassah University Hospital, Kiryat Hadassah
Hopital Foch -Pharmacie, Suresnes
Hopital Foch, Suresnes
Hôpital Henri Mondor, Créteil
Institut Gustave Roussy, Villejuif
Seattle Cancer Care Alliance, Seattle
University of Washington Medical Center, Seattle
Principal Military Clinical Hospital n.a. N.N. Burdenko, Moscow
Dr Ram Manohar Lohia (RML) Hospital & PGI MER, New Delhi
Rajiv Gandhi Cancer Institute And Research Centre, Delhi
Moscow Research Oncology Institute named after P. A. Gertsen, Moscow
"SHI YR Regional Clinical Oncology Hospital", Yaroslavl
"FGBIH Clinical Hospital #122 n.a. L.G. Sokolov of Federal Medico-biological agency", Saint Petersburg
"Non-State Healthcare Institution Railway Clinical Hospital JSC RZhD", Saint Petersburg
"Private Medical Institution Evromedservice", Pushkin
"FSBEI HE First St. Petersburg State Medical University n. a. academician l.P Pavlov MoH RF", Saint Petersburg
"FSBEI HE First St. Petersburg State Medical University n.a. academician I.P Pavlov MoH RF", Saint Petersburg
"FSBEI HE First St. Petersburg State Medical University n.a. academician I.P Pavlov", Saint Petersburg
"Ramsay Diagnostics Rus, LLC", Saint Petersburg
"FSBI Russian Scientific Center For Radiology and Surgical Technologies n.a. Academician A.M. Granov", Saint Petersburg
Hospital Orkli, LLC, Saint Petersburg
Mart, Llc, Saint Petersburg
"Federal State Budgetary Institution National medical research radiology center MoH RF", Obninsk
CIMS Cancer, Care Institute of Medical Sciences, CIMS Hospital, Ahmedabad
Sahyadri Super Speciality Hospital, Pune
State Budgetary Healthcare Insti. Republican Clinical Oncology Dispensary of the MoH of Bashk. Rep., Ufa
Apollo Hospitals, Hyderabad
"BHI of Omsk region Clinical oncological dispensary", Omsk
Medica Superspecialty hospital, Kolkata
The Chaim Sheba Medical Center, Tel Litwinsky
The Chaim Sheba Medical Center, Ramat Gan
Smilow Cancer Hospital at Yale New Haven, New Haven
Smilow Cancer Hospital at Yale-New Haven, New Haven
Massachusetts General Hospital, Boston
Seattle Cancer Care Alliance, Seattle
Centro de Investigacion Pergamino S.A., Pergamino
Fundación CENIT para la Investigación en Neurociencias, CABA
Centro Oncologico Riojano Integral (Cori), La Rioja
Hospital da Bahia, Salvador
CENOB Centro de Oncologia da Bahia S/S Ltda. / Oncovida, Salvador
Instituto Nacional de Câncer - INCA, Rio de Janeiro
Associacao Hospital de Caridade Ijui, Ijuí
ONCOSITE - Centro de Pesquisa Clinica em Oncologia, Ijuí
Associação Educadora São Carlos - AESC / Hospital Mãe de Deus, Porto Alegre
Associação Educadora São Carlos - AESC / Hospital Mãe de Deus - Ambulatório Quimioterapia, Porto Alegre
Associação Educadora São Carlos - AESC / Hospital Mãe de Deus - Centro de Abastecimento Farmaceut, Porto Alegre
Associação Educadora São Carlos - AESC / Hospital Mãe de Deus - Farmácia Oncológica, Porto Alegre
Associação Educadora São Carlos - AESC / Hospital Mãe de Deus, Porto Alegre
Hospital Mãe de Deus/Aesc, Porto Alegre
Uniao Brasileira de Educacao e Assistencia / Hospital Sao Lucas da PUCRS, Porto Alegre
Fundação FPio XII Barretos, Barretos
Fundação Pio XII Barretos, Barretos
Centro Integrado de Pesquisa Clinica - CIP, São José do Rio Preto
Fundacao Faculdade Regional de Medicina de Sao Jose do Rio Preto, São José do Rio Preto
Fundacao Faculdade de Medicina / Instituto do Cancer do Estado de Sao Paulo - ICESP, São Paulo
Sociedade Beneficente de Senhoras Hospital Sírio Libanês, São Paulo
Sociedade Beneficente de Senhoras Hospital Sírio Libanês, São Paulo
Sociedade Beneficente de Senhoras Hospital Sírio Libanês/ Instituo Sirio Libanes de Ensino e Pesqu, São Paulo
Hospital Alemao Oswaldo Cruz, São Paulo
Hospital das Clinicas da Faculdade de Medicina da USP - HCFMUSP, São Paulo
Hospital Israelita Albert Einstein - SP, São Paulo
William Osler Health System, Brampton
Princess Margaret Cancer Centre, Toronto
CHUM - Centre Hospitalier de l'Universite de Montreal, Montreal
Fakultni nemocnice u sv. Anny v Brne, Brno
Fakultni nemocnice u sv. Anny v Brne, Brno
Fakultni nemocnice u sv.Anny v Brne, Brno
Fakultni nemocnice Brno, Brno
Nemocnice Horovice, NH Hospital a.s., Hořovice
Nemocnice Horovice, Hořovice
Hopital de La Timone, Marseille
EUROMEDICA General Clinic of Thessaloniki, Thessaloniki
Department of Clinical Oncology, Hong Kong
Azienda Ospedaliera San Camillo Forlanini_Oncologia Medica, Rome
U.O.C. Farmacia, Rome
Azienda Ospedaliera S. Maria di Terni, Terni
S.C. Farmacia Interna, Terni
Nagoya University Hospital, Nagoya
Hirosaki University School of Medicine & Hospital, Hirosaki
National Hospital Organization Shikoku Cancer Center, Matsuyama
Gunma Prefectural Cancer Center, Ōta
National Hospital Organization hokkaido Cancer Center, Sapporo
Hokkaido University Hospital, Sapporo
Kobe City Medical Center General Hospital, Kobe
Tsukuba Medical Center Hospital, Tsukuba
Iwate Medical University Hospital, Shiwa-gun
National Hospital Organization Sagamihara National Hospital, Sagamihara
Kanagawa cancer center, Yokohama
Kindai University Hospital, Sayama
Saitama Medical University International Medical Center, Hidaka
Dokkyo Medical University Saitama Medical Center, Koshigaya
Hamamatsu University School of Medicine, University Hospital, Hamamatsu
Nihon University Itabashi Hospital, Itabashi-ku
The Cancer Institute Hospital of JFCR, Koto-Ku
Keio University Hospital, Shinjuku-Ku
Yamaguchi University Hospital, Ube
Chiba Cancer Center, Chiba
National Hospital Organization Kyushu Cancer Center, Fukuoka
Kyushu University Hospital, Fukuoka
Hiroshima City Hiroshima Citizens Hospital, Hiroshima
Kagoshima University Hospital, Kagoshima
National Hospital Organization Kumamoto Medical Center, Kumamoto
Niigata University Medical & Dental Hospital, Niigata
Osaka City University Hospital, Osaka
Tokushima University Hospital, Tokushima
Yamagata University Hospital, Yamagata
Rijnstate Arnhem, Arnhem
Ziekenhuis Rijnstate, Arnhem
St Apotheek der Haarlemse Ziekenhuizen, Haarlem
Spaarne Gasthuis, Hoofddorp
Maastricht University Medical Center, Maastricht
Radboud University Medical Center, Nijmegen
Radboudumc, Nijmegen
Centralny Szpital Kliniczny MSWiA w Warszawie, Warsaw
Centralny Szpital Kliniczny MSWiA, Warsaw
Centrum Onkologii Ziemi Lubelskiej im. Sw. Jana z Dukli, Lublin
Lecznice CITOMED Sp. z o.o., Torun
Wojewodzki Szpital Zespolony im. L. Rydygiera w Toruniu Szpital Obserwacyjno-Zakazny, Torun
Wojewodzki Szpital Zespolony im. L. Rydygiera w Toruniu, Torun
Wojewodzki Szpital Zespolony im. L. Rydygiera, Szpital Specjalistyczny dla Dzieci I Doroslych, Torun
Instituto Português de Oncologia de Coimbra Francisco Gentil, EPE, Coimbra
Hospital Da Luz Coimbra, SA, Coimbra
Centro Hospitalar de Lisboa Central, E.P.E. - Hospital de Santo António dos Capuchos, Lisbon
Hospital CUF Descobertas, SA, Lisbon
Dr. Campos Costa - Consultório de Tomografia Computorizada, S.A., Porto
Instituto Português de Oncologia do Porto Francisco Gentil, EPE, Porto
Centro Hospitalar de São João, EPE, Porto
Dr. Campos Costa - Consultório de Tomografia Computorizada, S.A.- Matosinhos, Senhora da Hora
Centro Hospitalar de Trás-os-Montes e Alto Douro, EPE, Vila Real
Severance Hospital Yonsei University Health System, Seoul
Asan Medical Center - Clinical Trial Pharmacy, Seoul
Asan Medical Center, Seoul
Samsung Medical Center Clinical Trial Pharmacy, Seoul
Samsung Medical Center, Seoul
Hospital Comarcal General de Elda de Virgen de la Salud, Elda
Hospital Universitario Germans Trias i Pujol, Badalona
Institut Catalá d'Oncología - Hospital Duran i Reynals, L'Hospitalet de Llobregat
Institut Catalá d'Oncología, L'Hospitalet de Llobregat
Althaia. Xarxa Assistencial Universitaria de Manresa, Manresa
Corporacio Sanitaria Parc Tauli, Sabadell
Hospital General Universitario de Elche, Elche
Hospital Vithas Internacional Medimar, Alicante
Hospital Universitario Infanta Cristina, Badajoz
Hospital del Mar, Barcelona
Hospital Quiron of Barcelona, Barcelona
Hospital Quiron, Barcelona
Hospital Quirón de Barcelona, Barcelona
Hospital de La Santa Creu i Sant pau_Oncology department, Barcelona
Hospital de La Santa Creu i Sant Pau, Barcelona
CETIR Grup Medic, Barcelona
Cetir, Centre Mèdic, S.L, Barcelona
Hospital de Vall d'Hebron, Barcelona
Hospital Universitario Vall d'Hebron, Barcelona
Hospital Clinic de Barcelona, Barcelona
Laboratorio Dr. F. Echevarne Analisis, S.A, Barcelona
APL, Stockholm
Karolinska University Hospital, Stockholm
Royal United Hospitals Bath NHS Foundation Trust, Bath
St Bartholomew 's Hospital, Barts Health NHS Trust, London
St. Bartholomew's Hospital, Barts Health NHS Trust, London
Guy's & St. Thomas' NHS Foundation Trust, London
Guy's and St Thomas' NHS Foundation Trust, Guy's Hospital, London
Churchill Hospital, Oxford University Hospitals NHS Trust, Oxford
Lead Sponsor
Pfizer
INDUSTRY