EZH2 Inhibitor Tazemetostat in Pediatric Subjects With Relapsed or Refractory INI1-Negative Tumors or Synovial Sarcoma

PHASE1CompletedINTERVENTIONAL
Enrollment

109

Participants

Timeline

Start Date

January 7, 2016

Primary Completion Date

June 19, 2021

Study Completion Date

October 22, 2021

Conditions
Rhabdoid TumorsINI1-negative TumorsSynovial SarcomaMalignant Rhabdoid Tumor of Ovary
Interventions
DRUG

Tazemetostat

Tazemetostat (EPZ-6438) is a selective small molecule inhibitor of the histone-lysine methyltransferase EZH2 gene.

Trial Locations (35)

2031

Sydney Children's Hospital, Sydney

2100

Rigshospitalet Department of Oncology Blegdamsvej, Copenhagen

2145

The Childrens Hospital at Westmead Oncology Unit, Westmead

3052

The Royal Children's Hospital, Melbourne

4101

Lady Cilento/Queensland Children's Hospital, South Brisbane

10065

Memorial Sloan Kettering, New York

13353

Charite - Universitatsmedizin Berlin, Berlin

16147

Istituto Giannina Gaslini- UOSD Centro di Neuro-Oncologia, Genova

19104

Children's Hospital of Philadelphia, Philadelphia

20010

Children's National Medical Center, Washington D.C.

20133

Fondazione IRCCS Istituto Nazionale dei Tumori, Milan

21287

John Hopkins Kimmel Cancer Center, Baltimore

30322

Children's Healthcare of Atlanta, Atlanta

38105

St. Jude Children's Research Hospital, Inc., Memphis

45229

Cincinnati Children's Hospital Medical Center, Cincinnati

48149

Westfalische Wilhelms - Universitat Munster Padiatrische, Münster

60611

Ann and Robert H. Lurie Children's Hospital of Chicago, Chicago

75235

UT Southwestern Medical Center, Dallas

75248

Institut Curie, Paris

77098

Texas Children's Cancer and Hematology Center, Houston

80045

Children's Hospital Colorado, Aurora

86156

Children's Hospital Augsburg Klinikum, Augsburg

90027

Children's Hospital of Los Angeles, Los Angeles

94158

University of California San Francisco - Benioff Children's Hospital, San Francisco

94800

Institut Gustave Roussy, Villejuif

97239

Oregon Health & Science University (OHSU), Portland

98105

Seattle Children's Hospital, Seattle

02215

Dana Farber Cancer Institute, Boston

Massachusetts General Hospital - Cancer Center, Boston

M5G 1X8

The Hospital for Sick Children, Toronto

Unknown

Universitaetsklinikum Heidelberg, Heidelberg

Erasmus University Medical Center - Sophia Children's Hospital, Rotterdam

3584 EA

Prinses Maxima Centrum voor Kinderoncologie, Utrecht

WC1N 3JH

Great Ormond Street Hospital for Children NHS Foundation Trust, London

M13 9WL

Central Manchester University Hospital - Royal Manchester Children's Hospital, Manchester

Sponsors

Lead Sponsor

All Listed Sponsors
lead

Epizyme, Inc.

INDUSTRY

NCT02601937 - EZH2 Inhibitor Tazemetostat in Pediatric Subjects With Relapsed or Refractory INI1-Negative Tumors or Synovial Sarcoma | Biotech Hunter | Biotech Hunter