Study of Brexucabtagene Autoleucel (KTE-X19) in Participants With Relapsed/Refractory Mantle Cell Lymphoma (Cohort 1 and Cohort 2)

PHASE2CompletedINTERVENTIONAL
Enrollment

105

Participants

Timeline

Start Date

November 9, 2015

Primary Completion Date

September 22, 2023

Study Completion Date

September 22, 2023

Conditions
Relapsed/Refractory Mantle Cell Lymphoma
Interventions
BIOLOGICAL

brexucabtagene autoleucel

A single infusion of brexucabtagene autoleucel (KTE-X19) anti-CD 19 CAR T cells

DRUG

Cyclophosphamide

Administered intravenously

DRUG

Fludarabine

Administered intravenously

DRUG

Axicabtagene Ciloleucel

A single infusion of axicabtagene ciloleucel anti-CD 19 CAR T cells

Trial Locations (32)

14642

University of Rochester Medical Center, Rochester

19111

Fox Chase Cancer Center, Philadelphia

27710

Duke University Medical Center, Durham

30322

Winship Cancer Institute of Emory University, Atlanta

33136

University of Miami, Miami

33612

H Lee Moffitt Cancer Center, Tampa

37203

Sarah Cannon Research Institute, Nashville

37232

Vanderbilt University Medical Center, Nashville

43210

Ohio State University, Columbus

44035

Hopital Haut-Leveque, Pessac

44195

Cleveland Clinic Foundation, Cleveland

48201

Barbara Ann Karmanos Cancer Institute, Detroit

60153

Loyola University Chicago, Maywood

60637

University of Chicago, Chicago

75010

Hospital Saint Louis, Paris

75246

Baylor Charles A. Sammons Cancer Center, Dallas

77030

University of Texas MD Anderson Cancer Center, Houston

80218

Sarah Cannon, Denver

85234

Banner MD Anderson, Gilbert

90404

University California Los Angeles (UCLA), Santa Monica

91010

City of Hope, Duarte

94305

Stanford University, Stanford

97080

Universitaetsklinikum Wuerzburg, Würzburg

97213

Robert W. Franz Cancer Research Center, Portland

98104

Swedish Cancer Institute, Seattle

02215

Dana-Farber Cancer Institute, Boston

07601

Hackensack University Medical Center, Hackensack

Unknown

Centre Hospitalier Universitaire (CHU), Bordeaux

Academisch Medisch Centrum, Amsterdam

University Medical Center Groningen, Groningen

Erasmus Medical Center, Rotterdam

01307

Universitätsklinik Dresden, Dresden

All Listed Sponsors
lead

Kite, A Gilead Company

INDUSTRY

NCT02601313 - Study of Brexucabtagene Autoleucel (KTE-X19) in Participants With Relapsed/Refractory Mantle Cell Lymphoma (Cohort 1 and Cohort 2) | Biotech Hunter | Biotech Hunter