114
Participants
Start Date
March 24, 2016
Primary Completion Date
December 15, 2021
Study Completion Date
December 15, 2021
Lenalidomide
All participants will receive lenalidomide oral capsules at doses of 10, 15, or 20 milligrams (mg) on Days 1 to 21 of each 28-day cycle for up to 6 Cycles in dose escalation phase followed by post-induction treatment at a dose of 10 mg once daily on Days 1 to 21 of each subsequent 28-day cycle. Post-induction lenalidomide may continue for up to 12 months until disease progression or unacceptable toxicity for participants with R/R FL and up to 6 months until disease progression or unacceptable toxicity for participants with R/R DLBCL.
Obinutuzumab
Participants will receive a fixed dose of obinutuzumab, 1000 mg via intravenous (IV) infusion to be given on Days 1, 8 and 15 of Cycle 1 and on Day 1 of Cycles 2 to 6 followed by post-induction treatment at a dose of 1000 mg via IV infusion on Day 1 of every other month for up to 24 months until disease progression or unacceptable toxicity.
Polatuzumab Vedotin
Participants with R/R FL will receive polatuzumab vedotin via IV infusion at doses of 1.4 or 1.8 milligrams per kilogram (mg/kg) on Day 1 of each 28-day cycle for up to 6 months during induction treatment. Participants wit R/R DLBCL will receive polatuzumab vedotin via IV infusion at dose 1.8 mg/kg on Day 1 of each 28-day cycle for up to 6 months during induction treatment.
Rituximab
Participants will receive a fixed dose of rituximab, 375 mg/m\^2 via intravenous (IV) infusion to be given on Days 1 of Cycle 1 to 6 followed by post-induction treatment at a dose of 375 mg/m\^2 via IV infusion on Day 1 of every other month for up to 6 months, until disease progression or unacceptable toxicity.
NYU School of Medicine, New York
Hospital Gregorio Marañon, Madrid
H. Universitario Leonor, Madrid
Hospital Universitario Fundacion Jimenez Diaz., Madrid
Hospital Clínico Málaga, Málaga
Northwest Georgia Oncology Centers, a Service of WellStar Cobb Hospital, Marietta
Complejo Hospitalario de Navarra, Pamplona
Clínica Universidad de Navarra, Pamplona
Barbara Ann Karmanos Cancer Institute, Detroit
Washington University; Wash Uni. Sch. Of Med, St Louis
University of Missouri/Ellis Fischel, Columbia
Rocky Mountain Cancer Centers, LLP, Irving
Texas Oncology-Tyler, Irving
Texas Oncology San Antonio Medical Center, San Antonio
Insititut Catala D'Oncologia, L'Hospitalet de Llobregat
Hospital Universitari Vall d'Hebron, Barcelona
Hospital Clínic. Barcelona, Barcelona
Hospital Santa Creu i Sant Pau, Barcelona
Hospital La Fe, Valencia
St James University Hospital, Leeds
University Hospitals of Leicester NHS Trust - Leicester Royal Infirmary, Leicester
Royal Liverpool University Hospital, Liverpool
Barts Hospital; Institute of Cancer, London
Sarah Cannon Research Institute, London
Maidstone & Tonbridge Wells Hospital; Kent Oncology Center, Maidstone
Nottingham University Hospitals NHS Trust - City Hospital, Nottingham
Barking, Havering and Redbridge University Hospitals NHS Trust - Queen's Hospital, Romford
The Royal Wolverhampton Hospitals NHS Trust; Department of Haematology, Wolverhampton
Hoffmann-La Roche
INDUSTRY