Assessment of Efficacy of Mirabegron, a New beta3-adrenergic Receptor in the Prevention of Heart Failure

PHASE2CompletedINTERVENTIONAL
Enrollment

296

Participants

Timeline

Start Date

September 12, 2016

Primary Completion Date

February 26, 2021

Study Completion Date

February 16, 2022

Conditions
Hypertrophy, Left Ventricular
Interventions
DRUG

mirabegron

50 mg daily during 12 months

PROCEDURE

Echocardiography

Echocardiography

PROCEDURE

Cardiac MRI

Cardiac MRI

PROCEDURE

Maximal exercise capacity

Maximal exercise capacity

PROCEDURE

Blood sampling

Blood sampling for study assessments and future exploratory studies.

PROCEDURE

Endothelial function measurement

EndoPAT assessment

RADIATION

18FDG-PET

PET scanning for beige/brown fat activation

Trial Locations (10)

1200

Cliniques universitaires Saint-Luc, Brussels

10115

Center for Cardiovascular Research Berlin (CCR/Charité), Berlin

37099

University Medical Center Göttingen (UMG-GOE), Göttingen

44000

Nantes university hospital (CHU Nantes), Nantes

Unknown

University of Leipzig, Leipzig

115 27

Athens University Medical School (NKUA), Athens

1 - 24127

"Hospital Papa Giovanni XXIII (HPG23)", Bergamo

50-981

Department of Heart Diseases at Wroclaw Medical University (UMW), Wroclaw

1649-028

Association for Research and Development of the Faculty of Medicine (AIDFM), Lisbon

OX3 9DU

University of Oxford - Division of Cardiovascular Medicine (UOXF), Oxford

All Listed Sponsors
collaborator

Zentrum für Klinische Studien Leipzig

OTHER

collaborator

European Clinical Research Infrastructure Network

OTHER

collaborator

European Society of Cardiology

NETWORK

collaborator

European Commission

OTHER

collaborator

Cliniques universitaires Saint-Luc- Université Catholique de Louvain

OTHER

collaborator

Northern Lisbon Hospital Center

OTHER

collaborator

University of Athens

OTHER

collaborator

Center for Cardiovascular Research Berlin

OTHER

collaborator

Wroclaw Medical University

OTHER

collaborator

Papa Giovanni XXIII Hospital

OTHER

collaborator

Nantes University Hospital

OTHER

collaborator

University Medical Center Goettingen

OTHER

collaborator

University of Oxford

OTHER

lead

Jean-Luc Balligand

OTHER

NCT02599480 - Assessment of Efficacy of Mirabegron, a New beta3-adrenergic Receptor in the Prevention of Heart Failure | Biotech Hunter | Biotech Hunter