NCT02595541View on ClinicalTrials.gov

Oral Sildenafil and Intravenous Milrinone on Postoperative Pulmonary Hypertension

PHASE1/PHASE2CompletedINTERVENTIONAL
Enrollment

30

Participants

Timeline

Start Date

June 30, 2015

Primary Completion Date

October 31, 2015

Study Completion Date

October 31, 2015

Conditions
Pulmonary Hypertension
Interventions
DRUG

milrinone

IV milrinone (0.75 mcg/kg) loading dose over one hour started during re-warming of the patient (before weaning from CPB) and followed by a maintenance dose of 0.75 mcg/kg/minutes till the end of the study.

DRUG

Sildenafil

IV milrinone (0.75 mcg/kg) loading dose over one hour started during re-warming of the patient (before weaning from CPB) and followed by a maintenance dose of 0.75 mcg/kg/minutes till the end of the study. After baseline measurements, sildenafil (1mg/kg) administered in ICU via a nasogastric tube, to be repeated every 4 hours via a nasogastric tube or orally. Sildnafil is presented in tablet form which was dissolved in water to make a concentration of 1 mg/ml.

All Listed Sponsors
lead

Assiut University

OTHER

NCT02595541 - Oral Sildenafil and Intravenous Milrinone on Postoperative Pulmonary Hypertension | Biotech Hunter | Biotech Hunter