Calcium Channel Blockers Compared to Magnesium Sulfate in Fetal Cerebral Blood Flow

PHASE2/PHASE3CompletedINTERVENTIONAL
Enrollment

130

Participants

Timeline

Start Date

December 31, 2015

Primary Completion Date

October 31, 2017

Study Completion Date

November 30, 2017

Conditions
Preterm LaborCerebral Palsy
Interventions
DRUG

Magesium sulphate

\*Experimental: Group A: Magesium sulphate 4 gm intravenous (I.V) loading dose over 30 mins \& 1 gm/ hour maintenance dose for 24 hours, or till labor occurs ( whichever occurs first)

DRUG

Nifedipine

\*Active Comparator: Group B Nifedipine wil be given in a loading dose of 40 mg in the 1st hour (10mg will be given every 15 min), then a maintenance dose of 60mg /24 hours, divided in 3 doses

RADIATION

Doppler on fetal middle cerebral artery

both group A and group B: ultrasound doppler to measure the mean pulsility index (PI) and resistance index (PI) of the middle cerebral artery in the fetus twice, once before giving them the drug, and the other after 4 hours of starting the loading dose.

Trial Locations (1)

11562

11562, Cairo

All Listed Sponsors
lead

Kasr El Aini Hospital

OTHER

NCT02591004 - Calcium Channel Blockers Compared to Magnesium Sulfate in Fetal Cerebral Blood Flow | Biotech Hunter | Biotech Hunter