110
Participants
Start Date
October 31, 2015
Primary Completion Date
September 30, 2022
Study Completion Date
September 30, 2022
Ibuprofen
Patients will be randomized using a computer generated number to received either ibuprofen (400mg by mouth every eight hours as needed) versus placebo for post-operative pain control in addition to opiate medication (hydrocodone/acetaminophen). Study doctors or research staff will be given randomly generated treatment allocations within sealed opaque envelopes. Once the patient is screened/qualified in surgery, the envelope will be opened and the patient randomized to the allocated treatment regimen. Patients will be given a two week supply (42 pills total) of either ibuprofen or placebo on the day of surgery upon discharge from the surgery center by a research coordinator.
Placebo
Pharmacy formulated placebo
UCSF Orthopaedic Institute, San Francisco
University of California, San Francisco
OTHER