Effect of RVX000222 on Time to Major Adverse Cardiovascular Events in High-Risk T2DM Subjects With CAD

PHASE3CompletedINTERVENTIONAL
Enrollment

2,425

Participants

Timeline

Start Date

November 30, 2015

Primary Completion Date

November 30, 2020

Study Completion Date

June 21, 2021

Conditions
Diabetes Mellitus, Type 2Coronary Artery Disease
Interventions
DRUG

Apabetalone

100 mg capsule

DRUG

Placebo

Capsule manufactured to mimic RVX000222 100 mg capsule

DRUG

Atorvastatin

High-Intensity Statin

DRUG

Rosuvastatin

High-Intensity Statin

Trial Locations (214)

Unknown

Instituto de Investigaciones Clinicas Bahia Blanca, Bahía Blanca

Bioclinica Buenos Aires, Buenos Aires

Centro Privado de Enfermedades Cardiovasculares, Buenos Aires

Consultorios Asociados Endocronología E Investigación Clínica Aplicada, Buenos Aires

Instituto Cardiovascular de Buenos Aires, Buenos Aires

Sanatorio Guemes, Buenos Aires

Clinica Coronel Suarez, Coronel Suárez

Instituto de Cardiologia de Corrientes Juana Francisca Cabral, Corrientes

CEMAIC, Córdoba

Centro Médico Colón, Córdoba

Centro Médico Luquez, Córdoba

Clínica Privada Del Prado Sociedad de Responsabilidad Limitada, Córdoba

Fundación Clínica Colombo, Córdoba

Hospital Cordoba, Córdoba

Hospital San Roque, Córdoba

Instituto Del Corazón, Córdoba

Instituto Modelo de Cardiologia, Córdoba

Instituto Médico DAMIC, Córdoba

Ipac Caraffa, Córdoba

Sanatorio Allende, Córdoba

Centro Médico Libertad, Haedo

CIMEL, Lanús

Instituto de Investigaciones Clínicas Mar Del Plata, Mar del Plata

Hospital Central, Mendoza

DIM Clinica Privada, Ramos Mejía

Instituto de Hematologia Y Medicina Clinica, Rosario

Sanatorio Britanico de Rosario, Rosario

Prevencion Cardio Vascular, Salta

Grupo Medico Alem, San Isidro

Bioclinica Tucumán, San Miguel de Tucumán

Centro Modelo de Cardiologia, San Miguel de Tucumán

Investigaciones Clinicas Tucuman, San Miguel de Tucumán

Centro de Investigaciones Clínicas Del Litoral SRL, Santa Fe

Sanatorio San Francisco, Santiago del Estero

Clínica FUSAVIM Privada, Villa María

Instituto de Investigaciones Clínicas Zárate, Zárate

Flinders Medical Centre, Bedford Park

ZNA Middelheim, Antwerp

Imelda VZW, Bonheiden

AZ Turnhout, Turnhout

Multiprofile Hospital For Active Treatment Dr Tota Venkova, Gabrovo

Multiprofile Hospital for Active Treatment - Prof. Dr. Paraskev Stoyanov AD, Lovech

Multiprofile Hospital For Active Treatment - Pazardzhik AD, Pazardzhik

University Multiprofile Hospital for Active Treatment - Dr. Georgi Stranski EAD, Pleven

Multiprofile Hospital For Active Treatment - Dr. Bratan Shukerov AD, Smolyan

Acibadem City Clinic Multiprofile Hospital for Active Treatment Tokuda, Sofia

City Clinic University Multiprofile Hospital for Active Treatment EOOD, Sofia

Medical Center Kardiohelp EOOD, Sofia

Second Multiprofile Hospital for Active Treatment Sofia, Sofia

Synexus Affiliate - Diagnostic and Consulting Center Ascendent, Sofia

University Multiprofile Hospital for Active Treatment Aleksandrovska EAD, Sofia

University Multiprofile Hospital for Active Treatment and Emergency Medicine N. I. Pirogov EAD, Sofia

Medical Center Orfey OOD, Stara Zagora

Multiprofile Hospital for Active Treatment Sveta Marina EAD, Varna

General Hospital Karlovac, Karlovac

Special Hospital for medicinal rehabilitation Krapinske Toplice, Krapinske Toplice

Clinical Hospital Osijek, Osijek

General Hospital Dr Josip Bencevic, Slavonski Brod

General Hospital Virovitica, Virovitica

Clinical Hospital Sveti duh, Zagreb

DRK Kliniken Berlin Westend, Berlin

Medizinisches Versorgungszentrum am Küchwald GmbH, Chemnitz

Zentrum für Klinische Prüfung in der Facharztzentrum Dresden Neustadt Gbr, Dresden

Katholisches Krankenhaus St. Johann Nepomuk, Erfurt

Heidelberger Praxisklinik für Kardiologie, Heidelberg

Klinikum Hoyerswerda, Hoyerswerda

Studienzentrum Dr.Appel, Kassel

Asklepios Klinik Langen, Langen

Klinikum Leverkusen GmbH, Leverkusen

Bajai Szent Rókus Kórház, Baja

Grof Tisza Istvan Korhaz Berettyoujfalu, Berettyóújfalu

Bajcsy-Zsilinszky Korhaz es Rendelointezet, Budapest

Del-pesti Centrumkorhaz- Orszagos Hematologiai és Infektologiai Intezet, Budapest

Gottsegen Gyorgy Orszagos Kardiologiai Intezet, Budapest

Magyar Honvédség Egészségügyi Központ, Budapest

Semmelweis Egyetem, Budapest

Synexus (DRS) - Synexus Magyarország Kft. Budapest, Budapest

Szent Margit Korhaz, Budapest

Szent Rókus Kórház és Intézményei, Budapest

Selye János Kórház, Komárom

TaNaMed Kft., Mosonmagyaróvár

Kanizsai Dorottya Kórház, Nagykanizsa

Coromed-SMO Kft., Pécs

Szegedi Tudomanyegyetem Szent-Gyorgyi Albert Klinikai Kozpont, Szeged

Tolna Megyei Balassa János Kórház, Szekszárd

Fejer Megyei Szent Gyorgy Egyetemi Oktato Korhaz, Székesfehérvár

Barzilai Medical Center, Ashkelon

Soroka University Medical Centre, Beersheba

Hillel Yaffe Medical Center, Hadera

Bnei Zion Medical Center, Haifa

Lady Davis Carmel Medical Center, Haifa

Linn Medical Center Clalit Health Services, Haifa

Rambam Medical Center, Haifa

Edith Wolfson Medical Center, Holon

Hadassah University Hospital Ein Kerem, Jerusalem

Hadassah University Hospital Mount Scopus, Jerusalem

Shaare Zedek Medical Center, Jerusalem

Meir Medical Center, Kefar Sava

Galilee Medical Center, Nahariya

Nazareth EMMS Hospital, Nazareth

Chaim Sheba Medical Center, Ramat Gan

Kaplan Medical Center, Rehovot

ZIV Medical Center, Safed

Clalit Health Medical Center, Tel Aviv

Tel Aviv Sourasky Medical Center, Tel Aviv

Baruch Padeh Poriya Medical Center, Tiberias

Fundacion Cardiovascular de Aguascalientes AC, Aguascalientes

Hospital Cardiológica Aguascalientes, Aguascalientes

Investigacion en Salud y Metabolismo S.C., Chihuahua City

Centro Para el Desarrollo de la Medicina y de Asistencia Especializada SC, Culiacán

Centro de Investigacion y Atencion de Diabetes, Endocrinologia y Nutricion, Durango

Arechavaleta Granell Maria del Rosario, Guadalajara

Centro de Investigacion Medica Biologica Y de Terapia Avanzada SC, Guadalajara

Unidad de Investigacion Clinica Cardiometabolica de Occidente SC, Guadalajara

Hospital Angeles Leon, León

Centro de Investigación Biomedica y Farmaceutica, Mexico City

Clinica Integral del Paciente Diabetico y Obeso, Mexico City

Fundación de Atención e Investigación Médica Lindavista S.C., Mexico City

Sanatorio y Servicios Médicos Obregón S.A. de C.V., Mexico City

Centro de Desarrollo Biomédico, Mérida

Instituto Cardiovascular de Monclova, Monclova

Hospital Universitario Dr. Jose Eleuterio González, Monterrey

IMED Internal Medicine Clin Trials, Monterrey

Unidad de Investigación Clínica En Medicina SC, Monterrey

Diabetes Total, S.A de C.V., Pachuca

Investigacion Biomedica Aplicada de Hidalgo S.A. de C.V., Pachuca

Cardioarritmias e Investigación S.C., San Luis Potosí City

Hospital Central Dr Ignacio Morones Prieto, San Luis Potosí City

INBIOMEDYC Toluca, Toluca

Centro de Alta Especialidad Dr. Rafael Lucio, Veracruz

Dr. Humberto Alvarez Lopez, Zapopan

Meander Medisch Centrum, Amersfoort

OLVG locatie Oost, Amsterdam

VU Medisch Centrum, Amsterdam

Podlaski Osrodek Kardiologii Poradnia Prywatna, Bialystok

Malopolskie Centrum Sercowo-Naczyniowe, Chrzanów

Polsko-Amerykanskie Kliniki Serca, Dąbrowa Górnicza

Gabinet Kardiologiczno-Internistyczny, Gdynia

Niepubliczny Zaklad Opieki Zdrowotnej Centrum Uslug Medycznych Promont-Med., Kielce

Diamond Clinic, Krakow

Szpital Specjalistyczny im. Jozefa Dietla w Krakowie, Krakow

Zespol Przychodni Specjalistycznych DIAB-END-COR Sp. z o.o., Krakow

Prywatna Praktyka Lekarska MAZ-MEDICA Maciej R.Mazurkiewicz, Lodz

Uniwersytecki Szpital Kliniczny im. Wojskowej Akademii Medycznej Centralny Szpital Weteranow, Lódz

Polsko-Amerykanskie Kliniki Serca, Nysa

Pro Corde, Dom Medyczny, Opole

Medicome Sp. z o.o., Oświęcim

Rodzinne Centrum Zdrowia, Otwock

"Niepubliczny Zaklad Opieki Zdrowotnej Specjalistyczna Przychodnia Lekarska MEDIKARD", Płock

Niepubliczny Zaklad Opieki Zdrowotnej Centrum Medyczne SBB, Tarnobrzeg

Centrum Medyczne doktorA, Warsaw

Instytut Kardiologii im Prymasa Tysiaclecia Kardynala Stefana Wyszynskiego, Warsaw

Niepubliczny Zaklad Opieki Zdrowotnej AURUM, Warsaw

Centrum Kardiologiczne Pro Corde Sp. z o.o. Niepubliczny Zaklad Opieki Zdrowotnej, Wroclaw

Wro Medica, Wroclaw

City Clinical Hospital #6, Chelyabinsk

Federal Budget Healthcare Institution Medici - sanitary unit of Ministry of internal affairs of Russ, Kemerovo

Research Institute of Complex Cardiovascular Pathology, Kemerovo

Krasnodar Regional Clinical Hospital #2, Krasnodar

Moscow City State Budgetary Healthcare Institution City Clinical Hospital named after V.V. Veresayev, Moscow

Russian Cardiology Research and Production Center, Moscow

City Hospital 13, Nizhny Novgorod

State Budgetary Healthcare Institution of Novosibirsk Region City Clinical Hospital No. 19, Novosibirsk

Republican Hospital n.a. V.A. Baranov, Petrozavodsk

Municipal Budgetary Healthcare Institution City Emergency Hospital, Rostov-on-Don

International Medical Center SOGAZ, Saint Petersburg

North-West State Medical University n.a. I.I. Mechnikov, Saint Petersburg

St Petersburg City Outpatient Clinic #109, Saint Petersburg

Saratov State Medical University, Saratov

State Healthcare Institution Regional Clinical Cardiologic Dispensary, Saratov

City Hospital #4, Sochi

Research Cardiology Institute of Tomsk Scientific Center of RAMS Siberian Branch, Tomsk

State Budgetary Healthcare Institution of Vladimir Region City Hospital No. 4, Vladimir

Ural State Medical University, Yekaterinburg

Clinical Center of Serbia, Belgrade

Clinical Hospital Centar Zvezdara, Belgrade

Clinical Hospital Center Bezanijska Kosa, Belgrade

Clinical Hospital Centre Zemun, Belgrade

Euromedik, Belgrade

Institute of Cardiovascular Diseases Dedinje, Belgrade

KBC Dr Dragisa Misovic Dedinje, Belgrade

Military Medical Academy, Belgrade

Institute of Cardiovascular Diseases of Vojvodina, Kamenitz

Clinical Center Kragujevac, Kragujevac

Clinical Center Nis, Niš

Institute Niska Banja, Niška Banja

Clinical Centre of Vojvodina, Novi Sad

General Hospital Uzice, Užice

Health Center Zajecar, Zaječar

ALIAN, s.r.o, Bardejov

CARDIOCONSULT, s.r.o., Bratislava

Univerzitna nemocnica Bratislava, Bratislava

Kardio-Onkologia, s.r.o., Dolný Kubín

CARDIO D&R, s.r.o. Kosice, Košice

Zeleznicne zdravotnictvo Kosice, s.r.o., Košice

KARDIOMED s.r.o., Lučenec

MEDI M&M s.r.o., Moldava nad Bodvou

Nemocnica s poliklinikou Nove Mesto nad Vahom n.o., Nové Mesto nad Váhom

Cardioinvest s. r. o., Nové Zámky

DIAB s.r.o., Rožňava

MEDIVASA, s.r.o., Žilina

Changhua Christian Hospital, Changhua

Kaohsiung Chang Gung Memorial Hospital, Kaohsiung City

Kaohsiung Veterans General Hospital, Kaohsiung City

Mackay Memorial Hospital-Taipei branch, New Taipei City

China Medical University Hospital, Taichung

National Cheng Kung University Hospital, Tainan City

Cathay General Hospital, Taipei

Chi Mei Medical Center, Taipei

Far Eastern Memorial Hospital, Taipei

National Taiwan University Hospital, Taipei

Taipei Veterans General Hospital, Taipei

Tri-Service General Hospital, Taipei

Chang Gung Medical Foundation Linkou Branch (Clinical Research Center), Taoyuan

All Listed Sponsors
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PPD Development, LP

INDUSTRY

collaborator

ICON plc

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collaborator

Medidata Solutions

INDUSTRY

lead

Resverlogix Corp

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