12
Participants
Start Date
November 30, 2015
Primary Completion Date
July 31, 2024
Study Completion Date
July 31, 2025
Calcium Chloride/Calcium Gluconate
Calcium (as either calcium chloride or calcium gluconate in half normal saline) will be delivered via IV during exercise to keep serum ionized calcium levels above baseline. The clamp is modeled after the hyperglycemic glucose clamp.
Half-Normal Saline
This is the placebo comparative infusion. Half-normal saline will be infused at the second collection visit following the identical infusion schedule determined during the calcium infusion visit.
University of Colorado Hospital, Aurora
National Center for Advancing Translational Sciences (NCATS)
NIH
University of Colorado, Denver
OTHER