Empagliflozin as Adjunctive to Insulin Therapy Over 26 Weeks in Patients With T1DM (EASE-3)

PHASE3CompletedINTERVENTIONAL
Enrollment

977

Participants

Timeline

Start Date

December 22, 2015

Primary Completion Date

September 12, 2017

Study Completion Date

September 20, 2017

Conditions
Diabetes Mellitus, Type 1
Interventions
DRUG

Empagliflozin

DRUG

Placebo

For blinding purposes

Trial Locations (189)

7

Mater Misericordiae University Hospital, Dublin

1002

P. Stradins Clinical University Hospital, Riga, Riga

Riga Health Center, Private Practice, Riga

1033

Clinexpert Kft., Budapest

1036

Synexus Magyarorszag Kft., Budapest

2021

LCS Clinical Research Unit, Bryanston

2150

Sigulda Hospital, Outpatient department, Sigulda

2198

Dr. L. A.Distiller, Johannesburg

2450

Coffs Endocrine & Diabetes Services, Coffs Harbour

3001

Zemgales Center of diabetes, Jelgava, Jelgava

3135

Eastern Clinical Research Unit, East Ringwood

3201

VSV Centrs, Stalte Private Practice, Talsi, Talsi

3401

A. Lucenko's Internist & Endocrinologist Doctor's Practice, Liepāja

3529

CRU Hungary Ltd, Private Practice, Miskolc, Miskolc

4032

University Debrecen Hospital, Debrecen

5001

Dace Teterovska Doctor's Practice in Endocrinology,Ogre, Ogre

5035

SA Endocrine Research P/L, Keswick

5112

Lyell McEwin Hospital, Elizabeth Vale

6600

Csongrad Country Dr Bugyi Istvan Hosp., Szentes

7100

Clinfan SMO Ltd., Szekszárd

7530

TREAD Research, Cape Town

7708

Dr Hilton Kaplan, Cape Town

8011

Lipid and Diabetes Research Group, Christchurch

8900

Zala Country Hospital, Diabetic Outpatient Clinic, Zalaegerszeg

10126

Ospedale Molinette, AO Città della Salute e della, Torino

11527

"General Hospital of Athens Laiko", Athens

11787

Endocrine Associates of Long Island, PC, Smithtown

14221

Diabetes Endocrinology Research Center of Western New York, Williamsville

14607

Endocrine-Diabetes Care and Resource Center, Rochester

15006

Hospital A Coruña, A Coruña

18003

CM Avances Médicos, Granada

18004

Hospital de la Inmaculada Concepción, Granada

18100

ResTrial s.r.o.Diabetology Ambulance,Prague, Prague

18484

General Hospital of Nikaia, Nikaia

20099

IRCCS Gruppo Multimedica, Sesto San Giovanni (MI)

20129

Clínica EndocrInol en Diabetes Obesidad y Tiroides (DOT), Aguascalientes

20230

Hospital Cardiologica Aguascalientes, Aguascalientes

21201

University of Maryland School of Medicine, Baltimore

21204

MODEL Clinical Research, Baltimore

23321

Virginia Endocrinology Research, Chesapeake

25030

HOP Jean Minjoz, Besançon

25123

A.O. Spedali Civili di Brescia, Brescia

28007

Hospital General Universitario Gregorio Marañón, Madrid

28031

Hospital Universitario Infanta Leonor, Madrid

28100

Satakunnan Diabetesasema, Pori, Pori

28557

Diabetes and Endocrinology Consultants, PC, Morehead City

29572

Strand Physician Specialists dba Carolina Health Specialists, Myrtle Beach

30046

Physicians Research Associates, LLC, Lawrenceville

30060

Sestron Clinical Research, Marietta

30281

Eagle's Landing Diabetes and Endocrinology, Stockbridge

30318

Atlanta Diabetes Associates, Atlanta

31059

HOP Rangueil, Toulouse Cédex 04

31547

Praxis Dr. Hilgenberg, Rehburg-Loccum

32225

Solutions Through Advanced Research, Inc., Jacksonville

33012

International Research Associates, LLC, Hialeah

33136

University of Miami, Miami

33520

FinnMedi Oy, Tampere, Tampere

34652

Suncoast Clinical Research, Inc., New Port Richey

36106

Healthscan Clinical Trials LLC, Montgomery

37411

University Diabetes and Endocrine Consultants, Chattanooga

37620

Holston Medical Group, Bristol

38133

AM Diabetes and Endocrinology Center, Bartlett

40100

Mehiläinen Jyväskylä, Jyväskylä

40503

Kentucky Diabetes Endocrinology Center, Lexington

41018

Endo-Diabesidad-Clínica Durán & Asociados, Seville

41071

Hospital Virgen Macarena, Seville

44137

Praxis Dr. Busch, Dortmund, Dortmund

44150

Unidad de Investigacion Clinica Cardiometabolica de Occident, Guadalajara

44600

Instituto Jaliscience de Inv. en Diabetes y Obesidad, S.C., Guadalajara

45136

InnoDiab Forschung GmbH, Essen

45500

Univ. Gen. Hosp. of Ioannina, Ioannina

45631

Holzer Clinic LLC, Gallipolis

46010

Hospital Clínico de Valencia, Valencia

48145

Institut für Diabetesforschung Münster GmbH, Münster

48153

Diabetologische Schwerpunktpraxis, Münster

53100

A.O.U. Senese Policlinico Santa Maria alle Scotte, Siena

54642

"General Hopsital of Thessaloniki Ippokrateio", Thessaloniki

55100

Osp. Campo di Marte, Lucca

55545

Diabetologische Schwerpunktpraxis, Bosenheim, Bosenheim

56564

Praxis Dr. Behnke, Neuwied, Neuwied

57010

"General Hospital of Thessaloniki G. Papanikolaou", Thessaloniki

60005

Northwest Endo Diabetes Research, LLC, Arlington Heights

60124

Inrca-Irccs, Ancona

60388

Praxis Dr. Kaiser, Frankfurt, Frankfurt

64111

Clinical Research Consultants, LLC, Kansas City

67091

HOP Civil, Strasbourg

71200

HOP Le Creusot, Le Creusot

73103

COR Clinical Research, LLC, Oklahoma City

75014

HOP Paris Saint-Joseph, Paris

75018

HOP Bichat, Paris

75218

Texas Health Physicians Group, Dallas

75230

Dallas Diabetes and Endocrine Center, Dallas

75231

Research Institute of Dallas, Dallas

78229

Endeavor Clinical Trials, PA, San Antonio

78749

Texas Diabetes & Endocrinology PA, Austin

80045

University of Colorado Denver, Aurora

80131

"Azienda Ospedaliera Universitaria Federico II", Napoli

86021

HOP de Poitiers, Poitiers

89052

Desert Endocrinology Clinical Research Center, Henderson

89128

Palm Research Center, Las Vegas

93105

William Sansum Diabetes Center, Santa Barbara

93720

Valley Research, Fresno

94520

John Muir Physician Network Clinical Research Center, Concord

94583

NorCal Endocrinology and Internal Medicine, San Ramon

94607

Pacific Research Partners, LLC, Oakland

94904

Marin Endocrine Care and Research, Greenbrae

97980

Diabetes-Klinik Bad Mergentheim GmbH & Co. KG, Bad Mergentheim

123423

City Clinical Hospital no. 67, Moscow, Moscow

190013

"CJSCPolyclinic complex,Dep.Endocrinology,St.Petersburg", Saint Petersburg

195030

City Outpatient dep.no.107;clinc.pharmacology,st.petersburg, Saint Petersburg

195067

Medical Academy named after I. Mechnikov, St. Petersburg, Saint Petersburg

195257

City Hospital Saint Elizaveta, Dept. Endocrinology, Saint Petersburg

199034

Policlinic No. 1 of Russian Academy of Sciences, St. Petersburg, Saint Petersburg

300456

Centrul Medical Dr Negrisanu SRL, Timișoara

410469

SC Pelican Impex SRL, Cabinet Nr. 201, Diabetes Dept., Oradea, Bihor County

T2T 5C7

Richmond Road and Diagnostic Treatment Centre, Calgary

T4N 6V7

The Bailey Clinic, Red Deer

A1B 3V6

Eastern Health (MUN), St. John's

N6G 2M1

Centre for Studies in Family Medicine, London

M5B 1W8

St. Michael's Hospital, Toronto

J7J 2K8

Omnispec Recherche Clinique Inc., Mirabel

H3Z 1E5

Applied Medical Informatics Research INC., Westmount

G1V 4M6

Clinique des maladies Lipidiques de Quebec, Québec

625 00

University Hospital Brno, Brno

769 01

Diahaza s.r.o.Intern.Med.Outpat.Clin.Dep.Diabetology,Holesov, Holešov

753 01

AIDIN VK s.r.o.,Department Diabetology, Hranice, Hranice

100 42

Univ. Hospital Kralovske Vinohrady, Prague

102 00

DiaGolfova s.r.o., Department Diabetology, Prague, Prague

149 00

Milan Kvapil s.r.o.,Diabetology ambulance,Prague, Prague

00290

HUS, Lihavuustutkimusyksikkö Biomedicum Helsinki, Helsinki

FI-20520

TYKS, Turku

01307

GWT-TUD GmbH, Dresden

04910

ZKS Südbrandenburg GmbH, Elsterwerda

115 26

"Korgialeneio-Benakeio Hellenic Red Cross Hospital", Athens

00168

Policlinico Gemelli, Roma

00186

Osp. S. Giovanni Calibita Fatebenefratelli, Roma

CP 44650

Unidad de Patologia Clinica, Guadalajara

1815 JD

Noordwest Ziekenhuisgroep, Alkmaar

7609 PP

Ziekenhuisgroep Twente locatie Almelo, Almelo

3813 TZ

Meander Medisch Centrum, Amersfoort

7334 DZ

Gelre Ziekenhuizen Apeldoorn, Apeldoorn

3511 NH

EB Utrecht Research, Utrecht

3584 CX

Universitair Medisch Centrum Utrecht, Utrecht

0610

South Pacific Clinical Trials, Auckland, New Zealand

N-2317

M3 Helse AS, Hamar

N-0027

Oslo Universitetssykehus HF, Lipidklinikken, Oslo

N-4068

Stavanger Helseforskning, Stavanger

N-9038

Universitetssykehuset Nord-Norge, Tromsø, Tromsø

41-500

DiabSerwis S.C., Chorzow, Chorzów

81-338

Medical Centre Pratia Gdynia, Gdynia

40-954

Medical Centre Pratia Katowice I, Katowice

30-002

Medical Centre Pratia Krakow, Krakow

31-501

University Hospital in Krakow, Krakow

20-081

Independent Public Clin.Hosp.no1Lublin,Dep.Internal Diseases, Lublin

20-090

Witold Chodzko Institute Rural Medic,Dep.Diabetology,Lublin, Lublin

10-561

Reg.Spec.Hosp.Olsztyn,Clin,Endocrinology,Diabetics.&Int.Med., Olsztyn

32-600

Clinical Research Center Medicome, Oswiecim, Oświęcim

60-111

Omedica Medical Centre, Poznan, Poznan

01-868

Medical Centre Pratia Warszawa, Warsaw

44-240

NZOZ Med-Art.Specialist Clinics, Zory, Żory

4710-243

Hospital de Braga-Escala Braga, Braga

6200-251

Centro Hospitalar da Cova da Beira Hospital Pêro da Covilhã, Covilha

1250-189

APDP - Associação Protectora dos Diabéticos de Portugal, Lisbon

4099-001

H. Santo António - Centro Hospitalar do Porto, Porto

4200-319

Centro Hospitalar São João,EPE, Porto

4901-858

ULSAM, EPE - Hospital de Santa Luzia, Viana do Castelo

4400-129

Centro Hospitalar de Vila Nova de Gaia, Vila Nova de Gaia

010507

Nicodiab SRL, Bucharest, Bucharest

010825

Milit. Cent. Emerg. Univ. Hosp. Dr. Davila, Met. Dis. Dept., Bucharest

020603

"SC Medical Centre Sanatatea Ta SRL, Bucharest", Bucharest

0087

VX Pharma (Pty) Ltd Pretoria, Pretoria

0181

Diabetes Care Centre, Pretoria

262 81

Ängelholms Sjukhus, Ängelholm

413 45

CTC Sahlgrenska Universitetssjukhuset, Gothenburg

691 81

Karlskoga lasarett, Karlskoga

221 85

Skånes universitetssjukhus, Lund, Lund

162 68

S3 Clinical Research Centers, Vällingby

BH7 7DW

Royal Bournemouth and Christchurch Hospital, Bournemouth

BD9 6RJ

Bradford Royal Infirmary, Bradford

HU3 2RW

Hull Royal Infirmary, Hull

IP4 5PD

Ipswich Hospital, Ipswich

LE5 4PW

Leicester General Hospital, Leicester

SE1 9RT

Guy's Hospital, London

SE5 9RJ

King's College Hospital, London

W2 1NY

St Mary's Hospital, London

TS4 3BW

James Cook University Hospital, Middlesbrough

NE1 4LP

Royal Victoria Infirmary, Newcastle upon Tyne

NG7 2UH

Queen's Medical Centre, Nottingham

CV10 7DJ

George Eliot Hospital, Nuneaton

Sponsors
All Listed Sponsors
collaborator

Eli Lilly and Company

INDUSTRY

lead

Boehringer Ingelheim

INDUSTRY