A Study Of Avelumab Alone Or In Combination With Pegylated Liposomal Doxorubicin Versus Pegylated Liposomal Doxorubicin Alone In Patients With Platinum Resistant/Refractory Ovarian Cancer (JAVELIN Ovarian 200)

PHASE3CompletedINTERVENTIONAL
Enrollment

566

Participants

Timeline

Start Date

December 21, 2015

Primary Completion Date

September 19, 2018

Study Completion Date

July 12, 2022

Conditions
Ovarian Cancer
Interventions
BIOLOGICAL

avelumab

10 mg/kg will be given as a 1 hour intravenous infusion (IV) every 2 weeks (Q2W) in 4 week cycles

DRUG

PLD

PLD (Arm B, Arm C) 40 mg/m2 will be given as a 1 hour IV infusion every 4 weeks (Q4W) in 4 week cycles

Trial Locations (295)

7

Mater Misericordiae University Hospital, Dublin

8

St James's Hospital, Dublin

100

National Taiwan University Hospital, Taipei

104

Mackay Memorial Hospital, Taipei

112

Clinical Trial Pharmacy, Taipei Veterans General Hospital, Taipei

Koo Foundation Sun Yat-Sen Cancer Center, Taipei

Taipei Veterans General Hospital, Taipei

333

Chang Gung Memorial Hospital - Linkou Branch, Taoyuan

Chemotherapy Pharmacy, Chang Gung Memorial Hospital - Linkou Branch, Taoyuan

701

Clinical Trial Pharmacy, National Cheng Kung University Hospital, Tainan City

704

National Cheng Kung University Hospital, Tainan City

1000

Institut Jules Bordet, Brussels

1122

Orszagos Onkologiai Intezet, Gyogyszertar, Budapest

Orszagos Onkologiai Intezet, Nogyogyaszati Osztaly, Budapest

2100

Rigshospitalet, Copenhagen

2305

Epic Pharmacy,Newcastle Private Hospital, New Lambton Heights

Newcastle Private Hospital Pty Limited, Newcastle

3000

Peter MacCallum Cancer Centre, Melbourne

Universitaire Ziekenhuizen Leuven, Leuven

3050

Royal Melbourne Hospital, Parkville

3052

Pharmacy Department, Parkville

The Royal Women's Hospital, Parkville

3144

Cabrini Health Limited, Malvern

3186

Cabrini Health Limited, Brighton

4000

CHU de Liege - Sart Tilman, Liège

4029

Clinical Research Unit, Herston

Metro North Hospital and Health Service, Herston

Oncology Pharmacy, Herston

4031

Universitatsspital Basel, Frauenklinik, Basel

Universitatsspital Basel, Basel

4032

Icon Cancer Care Chermside, Chermside

Debreceni Egyetem Klinikai Gyogyszertar, Debrecen

Debreceni Egyetem Klinikai Kozpont, Debrecen

4066

Icon Cancer Care Wesley, Auchenflower

Rivercity Pharmacy, Auchenflower

4101

Mater Pharmacy Services, Brisbane

Icon Cancer Care, South Brisbane

Icon Cancer Foundation, South Brisbane

Mater Cancer Care Centre, South Brisbane

4215

Icon Cancer Care Southport, Southport

5000

Clinique et Maternite Sainte Elisabeth, Namur

Jasz-Nagykun-Szolnok Megyei Hetenyi Geza Korhaz-Rendelointezet, Onkologiai Kozpont, Szolnok

5021

Department of Obstetrics and Gynecology, Haukeland University Hospital, Bergen

5053

Sykehusapoteket i Bergen, Bergen

6000

Luzerner Kantonsspital, Medizinische Onkologie, Studienzentrale Onkologie, Lucerne

6020

Medizinische Universitat Innsbruck, Innsbruck

6500

Oncology Institute of Southern Switzerland (IOSI), Bellinzona

8006

Kantonsapotheke Zurich, Zurich

8036

Medizinische Universitat Graz, LKH-Univ. Klinikum Graz, Graz

8091

Universitaetsspital Zurich, Klinik fuer Gynakologie, Zurich

Universitatsspital Zurich, Clinical Trials Center, Zurich

Universitatsspital Zurich, Institut fur diagnostische und interventionelle Radiologie, Zurich

Universitatsspital Zurich, Universitares Herzzentrum Zurich, Zurich

8500

AZ Groeninge Hospital, Kortrijk

9000

University Hospital Gent, Ghent

Aalborg University Hospital, Aalborg

10060

Fondazione del Piemonte per l'Oncologia, Candiolo

10122

C D C, Sede di Torino Centro, Torino

10408

National Cancer Center, Goyang-si

10449

Clinical Trial Pharmacy, Mackay Memorial Hospital, Taipei

11259

Clinical Trial Pharmacy, Koo Foundation Sun Yat-Sen Cancer Center, Taipei

11528

General Hospital of Athens Alexandra, Athens

12851

Vseobecna fakultni nemocnice v Praze, Prague

14004

Hospital Universitario Reina Sofia, Córdoba

14076

Centre Francois Baclesse, Caen

14564

"General Oncology Hospital of Kifissia Agioi Anargiroi, 2nd Department of Medical Oncology", Athens/New Kifissia

17007

lnstitut Catala d Oncologia de Girona. Hospital Universitario Dr. Josep Trueta, Girona

19104

Investigational Drug Services, University of Pennsylvania, Philadelphia

The University of Pennsylvania Health System, Philadelphia

19111

Fox Chase Cancer Center, Philadelphia

20121

ASST Fatebenefratelli Sacco, Miano

20141

Istituto Europeo di Oncologia, Milan

20817

Maryland Oncology Hematology, P.A., Bethesda

20902

Maryland Oncology Hematology P.A., Silver Spring

20904

Maryland Oncology Hematology P.A., Silver Spring

21044

Maryland Oncology Hematology, P.A., Columbia

22100

Congregazione delle Suore Infermiere dell'Addolorata, Como

23845

Congregazione delle Suore Infermiere dell'Addolorata, Costa Masnaga

24016

Carilion Clinic Gynecologic Oncology, Roanoke

Carilion Clinic, Roanoke

24122

Habilita, San Marco Bergamo, Bergamo

24125

Humanitas Cliniche Gavazzeni, Bergamo

Humanitas, Unita Operativa di Cardiologia 2, Bergamo

25025

Poliambulatorio Specialistico Villa Salute, Manerbio

25124

Fondazione Poliambulanza Istituto Ospedelario, Brescia

26100

Fondazione Teresa Camplani, Cremona

Regione Lombardia, A O Istituti Ospitalieri di Cremona, Cremona

Regione Lombardia, ASST Cremona, Cremona

27103

Novant Health Oncology Specialists, Winston-Salem

27284

Novant Health Oncology Specialists, Kernersville

28033

Hospital MD Anderson, Madrid

28046

Hospital Universitario La Paz, Madrid

28050

Centro Integral Oncologico Clara Campal, Madrid

28806

Hope Women's Cancer Centers, Asheville

Mission Hospital, Inc., Asheville

29121

Ambulatorio dott. Francesco Cavanna, Medico Chirurgo, Piacenza

Azienda Unita Sanitaria Locale di Piacenza, Piacenza

30060

Northwest Georgia Oncology Centers, P.C., Marietta

30106

Northwest Georgia Oncology Centers, P.C., Austell

30117

Northwest Georgia Oncology Centers, P.C., Carrollton

30121

Northwest Georgia Oncology Centers, P.C., Cartersville

30134

Northwest Georgia Oncology Centers, P.C., Douglasville

30342

Atlanta Gynecologic Oncology, Atlanta

Northside Hospital - Pharmacy, Atlanta

University Gynecologic Oncology, Atlanta

32117

Florida Cancer Specialists, Daytona Beach

33401

Florida Cancer Specialists, West Palm Beach

33414

Florida Cancer Specialists, Wellington

37055

Tennessee Oncology, PLLC, Dickson

37066

Tennessee Oncology, PLLC, Gallatin

37067

Tennessee Oncology, PLLC, Franklin

37076

Tennessee Oncology, PLLC, Hermitage

37090

Tennessee Oncology, PLLC, Lebanon

37129

Tennessee Oncology, PLLC, Murfreesboro

37160

Tennessee Oncology, PLLC, Shelbyville

37167

Tennessee Oncology, PLLC, Smyrna

37203

Tennessee Oncology, PLLC, Nashville

The Sarah Cannon Research Institute, Nashville

37205

Tennessee Oncology, PLLC, Nashville

37207

Tennessee Oncology, PLLC, Nashville

37211

Tennessee Oncology, PLLC, Nashville

40202

Norton Cancer Institute, Norton Healthcare Pavilion, Louisville

Norton Healthcare Pharmacy, Attn: Marlon Baranda, Pharm D, Louisville

Norton Hospital, Louisville

40207

Norton Cancer Institute, St. Matthews Campus, Louisville

Norton Women's and Children's Hospital, Louisville

40241

Norton Brownsboro Hospital, Louisville

Norton Cancer Institute, Brownsboro Hospital Campus, Louisville

41014

Hospital Universitario Virgen de Valme, Seville

41931

Clinical Trial Pharmacy, Keimyung University Dongsan Medical Center, Daegu

Keimyung University Dongsan Medical Center, Daegu

44106

Cleveland Clinic Taussig Cancer Center, Cleveland

44111

Fairview Hospital Moll Pavilion Cancer Center, Cleveland

Fairview Hospital Moll Pavilion Pharmacy, Cleveland

44124

Hillcrest Hospital Hirsch Cancer Center Pharmacy, Mayfield Heights

Hillcrest Hospital, Mayfield Heights

44195

Cleveland Clinic Taussig Cancer Center, Cleveland

Cleveland Clinic, Cleveland

47921

Servizio Sanitario Regionale Emilia-Romagna, Rimini

48022

Servizio Sanitario Regionale Emilia-Romagna, Lugo

53226

Froedtert and The Medical College of Wisconsin, Milwaukee

Froedtert Hospital, Milwaukee

54519

Institut de Cancérologie de Lorraine, Vandœuvre-lès-Nancy

59100

Azienda USL 4 Prato, Prato

Azienda USL 4 Toscana Centro, Prato

64154

The University of Kansas Cancer Center, CCP - North, Kansas City

66205

The University of Kansas Clinical Research Center, Fairway

The University of Kansas Cancer Center and Medical Pavilion, Westwood

69310

Centre Hospitalier Lyon Sud, Pierre-Bénite

69373

Centre Leon Berard, Lyon

Service de Radiologie, Lyon

72703

Highlands Oncology Group, Fayetteville

72758

Highlands Oncology Group, Rogers

75015

Hôpital Européen Georges Pompidou, Paris

75063

US Oncology Investigational Products Center (IPC), Irving

US Oncology Investigational Products Center, Irving

75908

Hôpital Européen Georges Pompidou, Paris

76022

Texas Oncology - Bedford, Bedford

76104

Texas Oncology -Fort Worth Cancer Center, Fort Worth

77380

Texas Oncology - The Woodlands, Gynecologic Oncology, The Woodlands

78240

Texas Oncology - San Antonio Medical Center, San Antonio

78731

Texas Oncology-Austin Central, Austin

78745

Texas Oncology-South Austin, Austin

80012

Rocky Mountain Cancer Centers, Aurora

80228

Rocky Mountain Cancer Centers, Lakewood

80303

Rocky Mountain Cancer Centers, Boulder

84106

Utah Cancer Specialists, Salt Lake City

85016

Arizona Oncology Associates, PC - HAL, Phoenix

85027

Arizona Oncology Associates, PC - HAL, Phoenix

85224

Arizona Oncology Associates, PC - HAL, Chandler

85258

Arizona Oncology Associates, PC - HAL, Scottsdale

85284

Arizona Oncology Associates, PC-HAL, Tempe

85704

Arizona Oncology Associates, PC - HOPE, Tucson

85711

Arizona Oncology Associates, PC - HOPE, Tucson

87106

Southwest GYN Oncology Associates, Inc., Albuquerque

University of New Mexico Comprehensive Cancer Center, Albuquerque

89502

Center of Hope at Renown Regional Medical Center, Reno

92868

University of California, Irvine/UC Irvine Health, Orange

93105

Sansum Clinic, Santa Barbara

93463

Sansum Clinic, Solvang

94805

Gustave Roussy Cancer Campus, Villejuif

97401

Willamette Valley Cancer Institute and Research Center, Eugene

115478

"Federal State Budgetary Institution Russian Cancer Research Center n.a. N.N. Blokhin", Moscow

119074

National University Hospital, Singapore

119082

National University Hospital, Singapore

169610

National Cancer Centre Singapore Pharmacy, Singapore

National Cancer Centre Singapore, Singapore

173016

"State Regional Budgetary Healthcare Institution Regional clinical oncology dispensary", Veliky Novgorod

188770

Raffles Hospital, Singapore

197758

State Budget Institution of Healthcare Saint Petersburg Clinical Scientific - Practice Center, Saint Petersburg

350040

"State Budgetary Healthcare Institution Clinical oncology dispensary #1", Krasnodar

354057

"State Budgetary Healthcare Institution Oncology Center #2 of the Ministry of Healthcare", Sochi

357502

State Budgetary Healthcare Institution Pyatigorsk Oncology Dispensary, Pyatigorsk

454048

Evimed Llc, Chelyabinsk

454087

State Budgetary Healthcare Institution, Chelyabinsk

460021

"State Budgetary Healthcare Institution Orenburg Regional Clinical Oncological Dispensary", Orenburg

603081

State Budgetary Healthcare Institution of Nizhegorogsky region, Nizhny Novgorod

9103102

Shaare Zedek Medical Center, Jerusalem

02114

Massachusetts General Hospital, Boston

02115

Brigham Women's Hospital, Boston

02215

Dana Farber Cancer Institute, Boston

T2N 4N2

Tom Baker Cancer Centre, Calgary

T6G 1Z2

Cross Cancer Institute, Edmonton

V1Y5L3

British Columbia Cancer Agency - Sindi Ahluwalia Hawkins Centre for the Southern Interior, Kelowna

V5Z 4E6

British Columbia Cancer Agency-Vancouver Centre, Vancouver

R2H 2A6

St. Boniface General Hospital, Winnipeg

R3A 1R9

Health Sciences Centre, Winnipeg

R3E 0V9

CancerCare Manitoba, Winnipeg

B3H 1V7

Nova Scotia Health Authority, QEII Health Sciences Centre, Nova Scotia Cancer Centre, Halifax

B3H 2Y9

Nova Scotia Health Authority, QEII Health Sciences Centre, Halifax

K1H 8L6

The Ottawa Hospital, Ottawa

M4N 3M5

Sunnybrook Research Institute, Toronto

M5G 2M9

Princess Margaret Cancer Centre, Toronto

H3T 1E2

Jewish General Hospital, Montreal

H4A 3J1

McGill University Health Centre - Glen Site, Montreal

Oncology Pharmacy McGill University Health Centre, Montreal

120 00

Vseobecna fakultni nemocnice v Praze, Fakultni poliklinika, Prague

Vseobecna fakultni nemocnice v Praze, Nemocnicni lekarna,, Prague

Vseobecna fakultni nemocnice v Praze, Neurologicka klinika, Prague

779 00

Fakultni nemocnice Olomouc, Olomouc

708 52

Fakultni nemocnice Ostrava, Ostrava-Poruba

150 06

Fakultni nemocnice v Motole, Prague

401 13

Krajska zdravotni a.s., Masarykova nemocnice v Usti nad Labem, o.z, Ústí nad Labem

06189

Centre Antoine Lacassagne, Nice

Unknown

Princess Margaret Hospital, Hong Kong

University of Hong Kong, Hong Kong

Pharmacy Department, Dublin

St Vincent's University Hospital, Dublin

University Hospital Waterford, Waterford

Dublin 7

Mater Private Hospital, Dublin

D7

Mater Misericoridae University Hospital, Dublin

Mater Private Hospital, Dublin

791-0280

Shikoku Cancer Center, Matsuyama

791-0295

Ehime University Hospital, Tōon

060-8648

Hokkaido University Hospital, Sapporo

673-8558

Hyogo Cancer Center, Akashi

305-8576

University of Tsukuba Hospital, Tsukuba

259-1193

Tokai University Hospital, Isehara

211-8533

Nippon Medical School Musashikosugi Hospital, Kawasaki

236-0004

Yokohama City University Hospital, Yokohama

980-8574

Tohoku University Hospital, Sendai

350-1298

Saitama Medical University International Medical Center, Hidaka

362-0806

Saitama Cancer Center, Kita-adachi-gun

359-8513

National Defense Medical College Hospital, Tokorozawa

430-8558

Seirei Hamamatsu General Hospital, Hamamatsu

329-0498

Jichi Medical University Hospital, Shimotsuke

113-8655

The University of Tokyo Hospital, Bunkyo-ku

104-0045

National Cancer Center Hospital, Chuo-ku

890-8520

Kagoshima University Hospital, Kagoshima

890-8760

Kagoshima City Hospital, Kagoshima

951-8566

Niigata Cancer Center Hospital, Niigata

9713 AP

Universitair Medisch Centrum Groningen, Groningen

9713 GZ

Universitair Medisch Centrum Groningen, Groningen

2333 ZA

LUMC, Leiden

6229 HX

Maastricht Universitair Medisch Centrum, Maastricht

0379

Oslo Universitetssykehus, Oslo

Sykehusapoteket Oslo, Oslo

31-115

Centrum Onkologii, Instytut im. M. Sklodowskiej-Curie, Oddzial w Krakowie, Apteka Szpitalna, Krakow

Centrum Onkologii, Instytut im. M. Sklodowskiej-Curie, Oddzial w Krakowie, Krakow

10-561

Wojewodzki Szpital Specjalistyczny w Olsztynie, Apteka Szpitalna, Olsztyn

Wojewodzki Szpital Specjalistyczny w Olsztynie, Olsztyn

60-569

Szpital Kliniczny Przemienienia Panskiego Uniwersytetu Medycznego im. Karola Marcinkowskiego w, Poznan

Szpital Kliniczny Przemienienia Panskiego Uniwersytetu Medycznego, Poznan

44-200

SPZOZ Wojewodzki Szpital Specjalistyczny nr 3 w Rybniku, Apteka Szpitalna, Rybnik

SPZOZ Wojewodzki Szpital Specjalistyczny nr 3 w Rybniku, Rybnik

02841

Korea University Anam Hospital, Seoul

03080

Seoul National University Hospital, Seoul

03722

Severance Hospital, Yonsei University Health System, Clinical Trial Pharmacy, Seoul

Severance Hospital, Yonsei University Health System, Seoul

05505

Asan Medical Center, Seoul

06351

Samsung Medical Center Clinical Trial Pharmacy, Seoul

Samsung Medical Center, Seoul

06591

Department of Pharamacy, The Catholic University of Korea, Seoul St. Mary's Hospital, Seoul

The Catholic University of Korea, Seoul St. Mary's Hospital, Seoul

The Catholic University of Korea, Seoul

08908

Institut Catala d'Oncologia - Hospital Duran y Reynalds, L'Hospitalet de Llobregat

CB2 0QQ

Cambridge University Hospitals NHS Foundation Trust, Cambridge

G52 3NQ

Ross Hall Hospital, Glasgow

CH63 4JY

The Clatterbridge Cancer Centre NHS Foundation Trust, Bebington, Wirral

The Clatterbridge Cancer Centre, Bebington, Wirral

HA6 2RN

East and North Hertfordshire NHS Trust, Northwood

NN1 5BD

Northampton General Hospital NHS Trust, Northampton

OX3 7LE

Oxford University Hospitals NHS Foundation Trust, Headington

SM2 5PT

The Royal Marsden NHS Foundation Trust, Sutton

SM3 9DW

Spire Healthcare Limited (St. Anthony's Hospital), Sutton

G12 0YN

NHS Greater Glasgow and Clyde, Glasgow

NW1 2PG

University College London Hospital NHS Foundation Trust, London

SE1 9RT

Guy's & St Thomas' NHS Foundation Trust, London

Guy's & St. Thomas' NHS Foundation Trust, London

SW3 6JJ

The Royal Marsden NHS Foundation Trust, London

W12 0HS

Imperial College Healthcare NHS Trust, London

WC1E 6AG

University College London Hospital NHS Foundation Trust, London

M20 4BX

The Christie Hospital NHS Foundation Trust, Manchester

NG5 1PB

Nottingham University Hospital NHS Trust, Nottingham

Nottingham University Hospitals NHS Trust, Nottingham

Sponsors

Lead Sponsor

All Listed Sponsors
lead

Pfizer

INDUSTRY

NCT02580058 - A Study Of Avelumab Alone Or In Combination With Pegylated Liposomal Doxorubicin Versus Pegylated Liposomal Doxorubicin Alone In Patients With Platinum Resistant/Refractory Ovarian Cancer (JAVELIN Ovarian 200) | Biotech Hunter | Biotech Hunter