950
Participants
Start Date
March 6, 2017
Primary Completion Date
February 1, 2021
Study Completion Date
April 15, 2021
allopurinol capsule, 100-800 mg by mouth once daily
Patients will be up-titrated up to the dose required to reach target uric acid levels.
febuxostat tablet 40-120 mg by mouth once daily
Patients will be up-titrated to the dose required to reach target uric acid levels.
Placebo, vehicle control (febuxostat-shaped)
Placebo tablets resembling febuxostat will be given with allopurinol.
Placebo, vehicle control (allopurinol-shaped)
Placebo capsules resembling allopurinol will be given with febuxostat.
Manhattan Campus of the VA NY Harbor Healthcare System, New York, NY, New York
VA Pittsburgh Healthcare System University Drive Division, Pittsburgh, PA, Pittsburgh
Corporal Michael J. Crescenz VA Medical Center, Philadelphia, PA, Philadelphia
Salem VA Medical Center, Salem, VA, Salem
Asheville VA Medical Center, Asheville, NC, Asheville
Miami VA Healthcare System, Miami, FL, Miami
Cincinnati VA Medical Center, Cincinnati, OH, Cincinnati
Minneapolis VA Health Care System, Minneapolis, MN, Minneapolis
Mayo Clinic Rochester MN ? RAIN 1, Rochester
Yankton Medical Clinic ? RAIN 3, Yankton
Sanford Bismarck Medical Center ? RAIN 2, Bismarck
Kansas City VA Medical Center, Kansas City, MO, Kansas City
VA North Texas Health Care System Dallas VA Medical Center, Dallas, TX, Dallas
VA Salt Lake City Health Care System, Salt Lake City, UT, Salt Lake City
VA San Diego Healthcare System, San Diego, CA, San Diego
VA Loma Linda Healthcare System, Loma Linda, CA, Loma Linda
San Francisco VA Medical Center, San Francisco, CA, San Francisco
VA Portland Health Care System, Portland, OR, Portland
Edward Hines Jr. VA Hospital, Hines, IL, Hines
VA Boston Healthcare System Jamaica Plain Campus, Jamaica Plain, MA, Boston
Omaha VA Nebraska-Western Iowa Health Care System, Omaha, NE, Omaha
University of Nebraska Medical Center ? RAIN 5, Omaha
White River Junction VA Medical Center, White River Junction, VT, White River Junction
VA Office of Research and Development
FED