1,214
Participants
Start Date
October 29, 2015
Primary Completion Date
December 6, 2021
Study Completion Date
January 29, 2024
Avelumab
Participants received Avelumab at a dose of 10 milligrams per kilogram (mg/kg) as a 1-hour (-10/+20 minutes) intravenous (IV) infusion once every 2 weeks until disease progression or unacceptable toxicities.
Pemetrexed
Participants received Pemetrexed 500 milligrams per square meter (mg/m\^2) by IV infusion on Day 1 of 3-Week cycle up to a maximum of 6 cycles of IV injection until disease progression or unacceptable toxicities.
Paclitaxel
Participants received Paclitaxel 200 mg/m\^2 by IV infusion on Day 1 of 3-Week cycle up to a maximum of 6 cycles of IV injection until disease progression or unacceptable toxicities.
Gemcitabine
Participants received Gemcitabine 1250 mg/m\^2 on Day 1 and Day 8 by IV infusion in 3-Week cycle up to a maximum of 6 cycles when combined with cisplatin of IV injection until disease progression or unacceptable toxicities.
Gemcitabine
Participants received Gemcitabine 1000 mg/m\^2 on Day 1 and Day 8 by IV infusion in 3-Week cycle up to a maximum of 6 cycles of IV injection when combined with carboplatin until disease progression or unacceptable toxicities.
Carboplatin
Participants received Carboplatin area under concentration curve (AUC) 5 mg/mL\*min in 3-Week cycle up to a maximum of 6 cycles of IV injection when combined with gemcitabine until disease progression or unacceptable toxicities.
Cisplatin
Participants received Cisplatin 75 mg/m\^2 by IV infusion in 3-Week cycle up to a maximum of 6 cycles of IV injection until disease progression or unacceptable toxicities.
Carboplatin
Carboplatin AUC 6 mg/mL\*min by IV infusion in 3-Week cycle up to a maximum of 6 cycles of IV injection when combined with pemetrexed, or paclitaxel until disease progression or unacceptable toxicities.
Avelumab Weekly
Participants received Avelumab at a dose of 10 mg/kg as a 1-hour (-10/+20 minutes) IV infusion every week for 12 consecutive weeks.
National Taiwan University Hospital, Taipei
Chang Gung Memorial Hospital, Linkou, Taoyuan
Mount Lebanon Hospital, Beirut
Hammoud Hospital University Medical Center, Saida
Auckland City Hospital, Auckland
Orszagos Koranyi Pulmonologiai Intezet, Budapest
Orszagos Onkologiai Intezet, Budapest
Semmelweis Egyetem, Budapest
MHAT for women's health - Nadezhda, OOD, Sofia
"UMHAT Sv. Ivan Rilski, EAD", Sofia
Emery Clinical Services, Alberton
Johese Clinical Research, Pretoria
Shato, Ead, Sofia
Bank of Cyprus Oncology Center, Nicosia
ZNA Middelheim, Antwerp
Tudogyogyintezet Torokbalint, Törökbálint
Royal North Shore Hospital, St Leonards
St George Private Hospital, Kogarah
Calvary Mater Newcastle, Waratah
Coffs Harbour Health Campus, Coffs Harbour
Lismore Base Hospital, Lismore
Albury Wodonga Regional Cancer Centre, Albury
Orange Health Service, Orange
A.Z. Klina, Brasschaat
Tauranga Hospital, Tauranga
Waikato Hospital, Hamilton
South West Healthcare, Warrnambool
Ballarat Base Hospital, Ballarat
Borsod-Abauj-Zemplen Megyei Kozponti Korhaz es Egyetemi Oktatokorhaz, Miskolc
Bendigo Hospital, Bendigo
Roskilde Sygehus, Roskilde
Gallipoli Medical Research Foundation Ltd, Greenslopes
Gold Coast University Hospital, Southport
SzSzB Megyei Korhazak es Egyetemi Oktatokorhaz, Nyíregyháza
Palmerston North Hospital, Palmerston North
The Queen Elizabeth Hospital, Woodville South
Wellington Hospital, Wellington
Fiona Stanley Hospital, Murdoch
Csongrad Megyei Mellkasi Betegsegek Szakkorhaza, Deszk
CHU Ambroise Paré, Mons
Complex Oncological Center - Ruse, EODD, Rousse
Tolna Megyei Balassa Janos Korhaz, Szekszárd
Herning Sygehus, Herning
Cape Town Oncology Trials Pty Ltd, Cape Town
Zala Megyei Szent Rafael Korhaz, Zalaegerszeg
Dunedin Public Hospital, Dunedin
Petz Aladar Megyei Oktato Korhaz, Győr
"University Hospital Centre Sestre Milosrdnice", Zagreb
King Chulalongkorn Memorial Hospital, Patumwan
Rajavithi Hospital, Rajathevee
National Cancer Center, Goyang-si
Siriraj Hospital, Bangkok
Institute of Oncology and Radiology of Serbia, Belgrade
Military Medical Academy, Belgrade
Clinical Center Bezanijska Kosa, Belgrade
Taipei Veterans General Hospital, Taipei
Tri-Service General Hospital, Taipei
"General Hospital of Athens of Chest Diseases SOTIRIA", Athens
"University General Hospital Attikon", Athens
Hôpital privé Clairval, Marseille
North Estonia Medical Centre Foundation, Tallinn
CHA Bundang Medical Center, CHA University, Seongnam-si
Seoul National University Bundang Hospital, Seongnam-si
Hôpital Nord - AP-HM Marseille#, Marseille
"General Oncology Hospital of Kifissia Agioi Anargyroi", Athens
Metropolitan General Hospital, Athens
Complejo Hospitalario Universitario de Santiago, Santiago de Compostela
Azienda Ospedaliero Universitaria San Martino, Genova
The Catholic University of Korea, St. Vincent's Hospital, Suwon
ICO Girona - Hospital Universitari de Girona Dr. Josep Trueta, Girona
Lancaster Cancer Center, Lancaster
Clinical Center Nis, Pulmonary Diseases Clinic, Gornji Matejevac
Hospital Universitario Donostia, Donostia / San Sebastian
Podilskyi Regional Oncological Center, Vinnytsia
Vinnytsia Regional Clinical Oncological Dispensary, Vinnytsia
Institute for Pulmonary Diseases of Vojvodina, Kamenitz
Gachon University Gil Medical Center, Incheon
LungenClinic Grosshansdorf GmbH, Großhansdorf
Treatment-Diagnostic Center of Private Enterprise of PPC Atsynus, Kropyvnytskyi
CHU Besançon - Hôpital Jean Minjoz, Besançon
Fondazione Poliambulanza Istituto Ospedaliero, Brescia
Nemocnice Na Plesi s.r.o., Nová Ves pod Pleší
Yonsei University Wonju Severance Christian Hospital, Wŏnju
University General Hospital of Patra, Pátrai
Novant Health Oncology Specialists, Kernersville
Hospital General Universitario Gregorio Marañon, Madrid
MD Anderson Cancer Centre, Madrid
Fundacion Jimenez Diaz, Madrid
Hospital Universitario La Paz, Madrid
Chungbuk National University Hospital, Cheongju-si
Hospital Regional Universitario de Malaga, Málaga
CHU Brest - Hôpital Morvan, Brest
South Georgia Medical Center, Valdosta
Mersin University Medical Faculty, Mersin
University Cancer Institute, Boynton Beach
Groupe Hospitalier Sud - Hôpital Haut-Lévêque, Pessac
Clinical Center Kragujevac, Kragujevac
Okmeydani Research and Training Hospital, Istanbul
Istanbul University Cerrahpasa Medical Faculty, Istanbul
Bakirkoy Dr. Sadi Konuk Teaching and Research Hospital, Istanbul
Medipol University Medical Faculty, Istanbul
Kartal Lutfi Kirdar Research and Training Hospital, Istanbul
Ege University Medical Faculty, Izmir
Clearview Cancer Institute, Huntsville
Complejo Hospitalario Universitario de Vigo, Vigo
Ospedale Mater Salutis, Legnago
Thompson Cancer Survival Center, Knoxville
Cookeville Regional Medical Center, Cookeville
Srinagarind Hospital, Muang
RCI Sumy Regional Clinical Oncological Dispensary, Sumy
Krajska zdravotni, a.s. - Masarykova nemocnice v Usti nad Labem, o.z., Ústí nad Labem
China Medical University Hospital, Taichung
Taichung Veterans General Hospital, Taichung
Hospital Quiron Sagrado Corazon, Seville
Hospital Universitario Virgen del Rocio, Seville
Kyungpook National University Chilgok Hospital, Daegu
Treatment-Prevention Institution Volyn Regional Oncological Dispensary, Lutsk
Azienda Ospedaliero Universitaria di Parma, Parma
Ulsan University Hospital, Ulsan
Inonu Uni. Med. Fac., Malatya
Inje University Haeundae Paik Hospital, Busan
Henry Ford Hospital, Detroit
Rabin Medical Center-Beilinson Campus, Petah Tikva
CI Dnipropetrovsk CMCH #4 of Dnipropetrovsk RC Dept of Chemotherapy SI Dnipropetrovsk MA of MOHU, Dnipro
CHU Angers - Hôpital Hôtel Dieu#, Angers
Hospital of Lithuanian University of Health Sciences Kaunas Clinics, Kaunas
CI Kryvyi Rih Oncological Dispensary of DRC, Kryvyi Rih, Dnipropetrovsk Region
Maharaj Nakorn Chiang Mai Hospital, Muang
Sakarya Traning and Research Hospital, Sakarya
Euromedica General Clinic Thessaloniki, Thessaloniki
Azienda Ospedaliero Universitaria Pisana, Pisa
CI Chernivtsi RC Oncological Dispensary Bukovinian SMU Ch of Oncology and Radiology, Chernivtsi
Namik Kemal University, Tekirdağ
St. Vincent Frontier Cancer Center, Billings
SI S.P.Grygoriev Institute of Medical Radiology of NAMSU, Kharkiv
Communal Non-profit Enterprise Regional Center of Oncology, Kharkiv
Centre Hospitalier de la Côte Basque, Bayonne
Naresuan University Hospital, Muang
Odesa Regional Oncologic Dispensary, Odesa
CHU de Strasbourg - Nouvel Hôpital Civil, Strasbourg
Universitaetsklinikum Heidelberg, Heidelberg
Centre Hospitalier de la Croix Rousse, Lyon
Christus Cancer Treatment Center, Shreveport
University General Hospital of Heraklion, Heraklion
Clinique Victor Hugo - Centre Jean Bernard, Le Mans
Kherson Regional Oncologic Dispensary, Kherson
Mercy Research, Oklahoma City
Assaf Harofeh, Rishon LeZiyyon
Hôpital Cochin, Paris
CI Transcarpathian Cl Onc Center Dep of Surgery#1 SHEI Ivano-Frankivsk NMU, Ivano-Frankivsk
Oncology Consultants, P.A., Houston
Coastal Bend Cancer Center, Corpus Christi
Lviv State Oncological Regional Treatment and Diagnostic Center, Lviv
Seconda Università degli Studi di Napoli, Napoli
Cheyenne Regional Medical Center, Cheyenne
Univerzitna nemocnica Bratislava, Nemocnica Ruzinov, Bratislava
Kaohsiung Chang Gung Memorial Hospital, Kaohsiung City
Institut Sainte Catherine, Avignon
Arizona Center for Cancer Care, Surprise
San Juan Oncology Associates, Farmington
CCCH City Oncological Center SHEI Uzhgorod NU, Uzhhorod
Nevada Cancer Research Foundation, Las Vegas
Songklanagarind Hospital, Hat Yai
Sharp Memorial Hospital, San Diego
Centre Hospitalier Intercommunal de Créteil, Créteil
Presidio Ospedaliero Garibaldi Nesima, Catania
Kaiser Permanente Northwest, Portland
Northwest Medical Specialties, PLLC, Tacoma
Beijing Cancer Hospital, Beijing
Liaoning Cancer Hospital & Institute, Shenyang
"FSBSI Russian Oncological Scientific Center n.a. N.N. Blokhin", Moscow
National University Cancer Institute, Singapore
"SBIH of Yaroslavl region Regional Clinical Oncological Hospital", Yaroslavl
Harbin Medical University Cancer Hospital, Harbin
"RBIH Ivanovo Regional Oncological Dispensary", Ivanovo
"SBIH of Arkhangelsk region Arkhangelsk Clinical Oncological Dispensary", Arkhangelsk
Hotel Dieu de France Hospital, Beirut
National Cancer Centre, Singapore
Murmansk Regional Clinical Hospital named after Bayandin, Murmansk
FSBHI Clinical research institute of phthisiopulmonology, Saint Petersburg
"SBIH Leningrad Regional Oncological Dispensary", Saint Petersburg
"Bio Eq LLC", Saint Petersburg
"FBI Scientific Research Institute of Oncology n. a. N. N. Petrov", Saint Petersburg
S.C Centrul de Oncologie Sf. Nectarie S.R.L, Craiova
IPS IMAT- Instituto Medico de Alta Tecnologia - Oncomedica S.A., Montería
"SBHI of Kaluga Region Kaluga regional clinical oncology dispensary", Kaluga
Linyi Cancer Hospital, Linyi
S.C Oncocenter Oncologie Clinica S.R.L, Timișoara
S.C Oncomed S.R.L, Timișoara
"RBIH Kursk regional clinical oncology dispensary of Kursk Region Healthcare Committee", Kursk
Tan Tock Seng Hospital, Singapore
"SBIH Oncological Dispensary # 2 of the MoH of Krasnodar territory", Sochi
"SBIH of Stavropol territory Pyatigorsk Oncological Dispensary", Pyatigorsk
"Institutul Oncologic Prof. Dr. Ion Chiricuta Cluj Napoca", Cluj-Napoca
S.C Medisprof S.R.L, Cluj-Napoca
"Spitalul Militar de Urgenta Dr.Constantin PapilianCluj -Napoca", Cluj-Napoca
S.C Radiotherapy Center Cluj S.R.L, Comuna Floresti
S.C Pelican Impex S.R.L, Oradea
"Spitalul Clinic Municipal Dr. Gavril Curteanu Oradea", Oradea
"SAIH Republican Clinical Oncological Dispensary of the Ministry of Healthcare of Republic Tatarstan", Kazan'
"Spitalul Judetean de Urgenta Dr. Constantin Opris Baia Mare", Baia Mare
"SBIH Samara Regional Clinical Oncological Dispensary", Samara
LLC Evimed, Chelyabinsk
Chelyabinsk Regional Oncology Dispensary, Chelyabinsk
S.C Policlinica de Diagnostic Rapid S.A, Brasov
Guangdong General Hospital, Guangzhou
Medicinskiy gorod, Tyumen
"SBHI of Novosibirsk region Novosibirsk Regional Oncological Dispensary", Novosibirsk
Tomsk Research Instutite of Oncology, Tomsk
"BHI of Omsk region Clinical Oncology Dispensary", Tomsk
Kemerovo SPI Regional Clinical Oncology Dispensary, Kemerovo
"SBHI Krasnoyarsk Regional Oncology Dispensary n.a. A.I. Kryzhanovsky", Krasnoyarsk
Irkutsk Regional Oncology Dispensary, Irkutsk
Institutul Regional de Oncologie Iasi, Iași
"Spitalul Judetean de Urgenta Sf. Ioan cel Nou Suceava", Suceava
"Spitalul Clinic Judetean de Urgenta Sf. Apostol Andrei Constanta", Constanța
Hospital Clinico Viña del Mar, Viña del Mar
Centro de Investigaciones Clinicas Viña del Mar, Viña del Mar
Rambam Health Care Center, Haifa
Sapir Medical Center, Meir Hospital, Kfar Saba
Chaim Sheba Medical Center, Ramat Gan
Tel Aviv Sourasky Medical Center, Tel Aviv
Fundación Oftalmológica de Santander - FOSCAL, Floridablanca
FALP - Fundación Arturo López Pérez, Santiago
Clinica Santa Maria, Santiago
Kaplan Medical Center, Rehovot
IRAM - Instituto de Radio Medicina, Santiago
Hospital Militar de Santiago, Santiago
Hospital Clínico San Borja Arriaran, Santiago
Hospital Clínico Universidad de Chile, Santiago
Soroka University Medical Center, Beersheba
Hadassah University Hospital - Ein Kerem, Jerusalem
University of Vermont Medical Center, Burlington
CRIO - Centro Regional Integrado de Oncologia, Fortaleza
NOB - Núcleo de Oncologia da Bahia, Salvador
CEBROM - Centro Brasileiro de Radioterapia, Oncologia e Mastologia, Goiânia
Hospital Erasto Gaertner - Liga Paranaense de Combate ao Câncer, Curitiba
Hospital de Caridade de Ijuí, Ijuí
Hospital Bruno Born, Lajeado
Hospital São Vicente de Paulo, Passo Fundo
Hospital de Clínicas de Porto Alegre, Porto Alegre
IMV-Pesquisa Cardiologica Sociedade Simples - HMD - COR, Porto Alegre
Hospital São Lucas da PUCRS, Porto Alegre
Hospital Nossa Senhora da Conceição, Porto Alegre
CEPON - Centro de Pesquisas Oncológicas de Santa Catarina, Florianópolis
Clínica de Neoplasias Litoral Ltda., Itajaí
Hospital de Câncer de Barretos - Fundação Pio XII, Barretos
Fundação Doutor Amaral Carvalho, Jaú
CEPHO - Centro de Estudos e Pesquisas em Hematologia e Oncologia, Santo André
Fundação Faculdade Regional de Medicina de São José do Rio Preto, São José do Rio Preto
ICESP - Instituto do Câncer do Estado de São Paulo Octavio Frias de Oliveira, São Paulo
IBCC - Instituto Brasileiro de Controle do Câncer, São Paulo
INCA - Instituto Nacional de Câncer, Rio de Janeiro
The Moncton Hospital, Moncton
Mount Sinai Hospital, Toronto
Administradora Country S.A., Bogotá
Hospital Pablo Tobón Uribe, Medellín
University Clinic for Pulmonary Diseases, Zagreb
Krajska nemocnice Liberec, a.s., Liberec
Fakultni nemocnice Olomouc, Olomouc
Vitkovicka nemocnice a.s, Ostrava - Vitkovice
Thomayerova nemocnice, Praha 4 - Krc
Centre Antoine Lacassagne, Nice
Hôpital Saint-Louis - Paris, Paris
Orszagos Koranyi Pulmonologiai Intezet, Budapest
Cork University Hospital, Cork
Mazowieckie Centrum Leczenia Chorob Pluc i Gruzlicy, Otwock
251 General Air Force Hospital, Athens
National Cancer Center Hospital East, Kashiwa-shi
Kurume University Hospital, Kurume-shi
NHO Hokkaido Cancer Center, Sapporo
Institute of Biomedical Research and Innovation Hospital, Kobe
Kobe City Hospital Organization Kobe City Medical Center General Hospital, Kobe
Kobe City Hospital Organization Kobe City Medical Center General Hospital, Kobe
Yokohama Municipal Citizen's Hospital, Yokohama
Kanagawa Cancer Center, Yokohama
Kansai Medical University Hospital, Hirakata-shi
Osaka Medical College Hospital, Takatsuki-shi
National Cancer Center Hospital, Chūōku
Tokyo Medical University Hospital, Shinjuku-ku
Toyama University Hospital, Toyama
American University of Beirut Medical Center, Beirut
Rafik Hariri University Hospital, Beirut
Martini Ziekenhuis, Groningen
Westfriesgasthuis - PARENT, Hoorn
ETZ Elisabeth, Tilburg
Instituto Nacional de Enfermedades Neoplásicas, Lima
Clinica Internacional Sede San Borja, Lima
Oncosalud, Lima
Centrum Terapii Wspolczesnej J.M. Jasnorzewska sp. komandytowo-akcyjna, Lodz
Instytut MSF Sp. o.o, Lodz
Wojewódzkie Wielospecjalistyczne Centrum Onkologii i Traumatologii im. M. Kopernika w Łodzi, Lodz
KO-MED Centra Kliniczne Lublin II, Lublin
SSZZOZ im. Dr Teodora Dunina w Rudce, Mrozy
SP Zespol Gruzlicy i Chorob Pluc w Olsztynie, Olsztyn
Szpital Kliniczny Przemienienia Panskiego Uniwersytetu Medycznego im. Karola Marcinkowskiego, Poznan
"Izerskie Centrum Pulmonologii i Chemioterapii IZER-MED Spolka z o.o.", Szklarska Poręba
Centrum Onkologii-Instytut im. M. Sklodowskiej Curie, Warsaw
Mazowiecki Szpital Onkologiczny, Wieliszew
Hospital Garcia de Orta, EPE, Almada
Hospital Professor Doutor Fernando Fonseca, E.P.E., Amadora-Lisbon
Centro Hospitalar De Coimbra-CHUC, Coimbra
Centro Hospitalar e Universitário de Coimbra, E.P.E (CHC), Coimbra
Centro Hospitalar de Lisboa Norte, E.P.E. - Hospital Pulido Valente, Lisbon
Centro Hospitalar de Lisboa Central, E.P.E. - Hospital de Santo António dos Capuchos, Lisbon
Centro Hospitalar do Porto, E.P.E. - Hospital de Santo António, Porto
Hospital CUF Porto, Porto
Instituto Português de Oncologia do Porto Francisco Gentil, EPE, Porto
Centro Hospitalar de São João, E.P.E., Porto
Centro Hospitalar de Entre o Douro e Vouga, E.P.E - Hospital de São Sebastião, Santa Maria da Feira
Centro Hospitalar Vila Nova de Gaia/Espinho, E.P.E, Vila Nova de Gaia
"Institutul Oncologic Prof. Dr. Al. Trestioreanu", Bucharest
Spitalul Clinic Coltea, Bucharest
S.C Gral Medical S.R.L, Bucharest
Clinical Center of Serbia, Belgrade
Nemocnica s poliklinikou Sv. Jakuba, n.o. Bardejov, Bardejov
University of Pretoria Oncology Department, Pretoria
Ajou University Hospital, Suwon
Korea University Anam Hospital, Seoul
Seoul National University Hospital, Seoul
Severance Hospital, Yonsei University, Seoul
Asan Medical Center, Seoul
Samsung Medical Center, Seoul
The Catholic University of Korea, Seoul St. Mary's Hospital, Seoul
The Catholic University of Korea, Yeouido St. Mary's Hospital, Seoul
Korea University Guro Hospital, Seoul
Hospital de Mataro, Mataró
Hospital Universitario Mutua de Terrassa, Terrassa
Specialist, Barcelona
Hospital Universitari Quiron Dexeus, Barcelona
Hospital Universitari Vall d'Hebron, Barcelona
Hospital de la Santa Creu i Sant Pau, Barcelona
Hospital Txagorritxu, Vitoria-Gasteiz
Acibadem Adana Hospital, Adana
Baskent University Adana Application and Research Center, Adana
Adana Numune Training and Research Hospital, Adana
Cukurova University Medical Faculty, Adana
Adana City Hospital, Adana
Ankara University Medical Faculty, Ankara
Dr. Abdurrahman Yurtaslan Ankara Oncology Training and Research Hospital, Ankara
Hacettepe University Medical Faculty, Ankara
Memorial Antalya Hastanesi, Antalya
Kyiv City Clinical Oncological Center, Kyiv
Southend University Hospital, Westcliff-on-Sea
Cheltenham General Hospital, Cheltenham
Chelsea and Westminster Hospital, London
Mount Vernon Hospital, Stevenage
The Clatterbridge Cancer Centre, Metropolitan Borough of Wirral
Royal Stoke University Hospital, Stoke-on-Trent
Merck KGaA, Darmstadt, Germany
INDUSTRY
EMD Serono Research & Development Institute, Inc.
INDUSTRY