An Investigational Immuno-therapy Study of Nivolumab Compared to Sorafenib as a First Treatment in Patients With Advanced Hepatocellular Carcinoma

PHASE3CompletedINTERVENTIONAL
Enrollment

743

Participants

Timeline

Start Date

December 7, 2015

Primary Completion Date

May 30, 2019

Study Completion Date

February 7, 2024

Conditions
Hepatocellular Carcinoma
Interventions
DRUG

Nivolumab

Specified Dose on Specified Days

DRUG

Sorafenib

Specified Dose on Specified Days

Trial Locations (138)

0

Local Institution - 0011, Hong Kong

Local Institution - 0062, Bergamo

704

Local Institution - 0121, Tainan City

736

Local Institution - 0132, Tainan City

1000

Local Institution - 0075, Brussels

1090

Local Institution - 0038, Vienna

2050

Local Institution - 0005, Camperdown

3000

Local Institution - 0091, Leuven

3010

Local Institution - 0041, Bern

3084

Local Institution - 0002, Heidelberg

3168

Local Institution - 0001, Clayton

3181

Local Institution - 0003, Prahran

4000

Local Institution - 0077, Liège

4031

Local Institution - 0040, Basel

5000

Local Institution - 0007, Adelaide

6009

Local Institution - 0008, Nedlands

8036

Local Institution - 0039, Graz

10002

Local Institution - 0099, Taipei

10029

Local Institution - 0083, New York

10043

Local Institution - 0063, Orbassano

10065

Local Institution - 0093, New York

10408

Local Institution - 0116, Goyang-si

11217

Local Institution - 0120, Taipei

13353

Local Institution - 0036, Berlin

15706

Local Institution - 0010, Santiago Compostela

19104

Local Institution - 0095, Philadelphia

19107

Local Institution - 0019, Philadelphia

20133

Local Institution - 0055, Milan

20246

Local Institution - 0034, Hamburg

28204

Local Institution - 0016, Charlotte

28222

Local Institution - 0085, Majadahonda - Madrid

31008

Local Institution - 0009, Pamplona

31059

Local Institution - 0074, Toulouse

31096

Local Institution - 0082, Haifa

33305

Local Institution - 0128, Taoyuan

33604

Local Institution - 0068, Pessac

34295

Local Institution - 0073, Montpellier

35042

Local Institution - 0070, Rennes

35294

Local Institution - 0066, Birmingham

38700

Local Institution - 0071, La Tronche

40447

Local Institution - 0133, Taichung

41944

Local Institution - 0125, Daegu

45136

Local Institution - 0037, Essen

49100

Local Institution - 0058, Petah Tikva

53100

Local Institution - 0064, Siena

53792

Local Institution - 0050, Madison

55131

Local Institution - 0035, Mainz

58128

Local Institution - 0118, Jeollanam-do

59037

Local Institution - 0072, Lille

60590

Local Institution - 0167, Frankfurt

60637

Local Institution - 0061, Chicago

64239

Local Institution - 0059, Tel Aviv

69004

Local Institution - 0069, Lyon

70121

Ochsner Clinic Foundation, New Orleans

72076

Local Institution - 0030, Tübingen

75390

UT Southwestern Medical Center, Dallas

75651

Local Institution - 0067, Paris

76508

Scott & White Memorial Hospital And Clinic, Temple

78229

Local Institution - 0017, San Antonio

80952

Local Institution - 0023, Gdansk

81366

Local Institution - 0033, Munich

82100

Local Institution - 0054, Benevento

83301

Local Institution - 0129, Kaohsiung County

90095

Local Institution - 0020, Los Angeles

91120

Local Institution - 0060, Jerusalem

93053

Local Institution - 0032, Regensburg

94115

Local Institution - 0015, San Francisco

94143

Local Institution - 0084, San Francisco

98101

Local Institution - 0026, Seattle

98109

University of Washington - Seattle Cancer Care Alliance, Seattle

100050

Local Institution - 0139, Beijing

100071

Local Institution - 0137, Beijing

100142

Local Institution - 0140, Beijing

Local Institution - 0141, Beijing

115478

Local Institution - 0096, Moscow

116000

Local Institution - 0166, Dalian

130012

Local Institution - 0136, Changchun

130021

Local Institution - 0163, Changchun

155040

Local Institution - 0142, Harbin

168583

Local Institution - 0013, Singapore

200032

Local Institution - 0145, Shanghai

Local Institution - 0151, Shanghai

210002

Local Institution - 0135, Nanjing

213003

Local Institution - 0169, Changzhou

230061

Local Institution - 0164, Hefei

300060

Local Institution - 0159, Tianjin

308433

Local Institution - 0014, Singapore

310003

Local Institution - 0173, Hangzhou

310022

Local Institution - 0146, Hangzhou

350025

Local Institution - 0152, Fuzhou

410013

Local Institution - 0148, Changsha

Local Institution - 0162, Changsha

510060

Local Institution - 0161, Guangzhou

510080

Local Institution - 0157, Guangzhou

510515

Local Institution - 0144, Guangzhou

530021

Local Institution - 0158, Nanning

710038

Local Institution - 0138, Xi'an

1628655

Local Institution - 0126, Shinjuku-ku

2138587

Local Institution - 0110, Kawasaki-shi

2320024

Local Institution - 0112, Yokohama

2418515

Local Institution - 0104, Yokohama

2608670

Local Institution - 0100, Chiba

5038502

Local Institution - 0127, Ogaki-shi

5650871

Local Institution - 0113, Suita

5898511

Local Institution - 0106, Osaka-Sayama-Shi

6028566

Local Institution - 0111, Kyoto

7900024

Local Institution - 0103, Matsuyama

8300011

Local Institution - 0107, Kurume-shi

8408571

Local Institution - 0115, Saga

9208641

Local Institution - 0105, Kanazawa

T2N 4N2

Local Institution - 0043, Calgary

V5Z 4E6

Local Institution - 0044, Vancouver

G1R 2J6

Local Institution - 0042, Québec

656 53

Local Institution - 0029, Brno

500 05

Local Institution - 0027, Hradec Králové

779 00

Local Institution - 0028, Olomouc

04103

Local Institution - 0031, Leipzig

Unknown

Local Institution - 0012, Hong Kong

0600033

Local Institution - 0102, Sapporo

0608648

Local Institution - 0130, Sapporo

101-0062

Local Institution - 0131, Chiyoda-ku

181-8611

Local Institution - 0114, Mitaka-shi

180-8610

Local Institution - 0108, Musashino-shi

734-8551

Local Institution - 0101, Hiroshima

02-781

Local Institution - 0056, Warsaw

50-556

Local Institution - 0045, Wroclaw

06591

Local Institution - 0117, Seoul

03080

Local Institution - 0123, Seoul

03722

Local Institution - 0119, Seoul

05505

Local Institution - 0122, Seoul

06351

Local Institution - 0124, Seoul

03010

Local Institution - 0065, Alicante

413 45

Local Institution - 0088, Gothenburg

141 86

Local Institution - 0087, Stockholm

NW3 2QG

Local Institution - 0080, London

SE5 9RS

Local Institution - 0078, London

G12 0YN

Local Institution - 0079, Glasgow

L7 8YA

Local Institution - 0081, Liverpool

Sponsors
All Listed Sponsors
collaborator

Ono Pharmaceutical Co. Ltd

INDUSTRY

lead

Bristol-Myers Squibb

INDUSTRY