A Study to Test the Effect of the Drug Larotrectinib in Adults and Children With NTRK-fusion Positive Solid Tumors

PHASE2Active, not recruitingINTERVENTIONAL
Enrollment

215

Participants

Timeline

Start Date

September 30, 2015

Primary Completion Date

October 31, 2025

Study Completion Date

October 31, 2025

Conditions
Solid Tumors Harboring NTRK Fusion
Interventions
DRUG

BAY2757556 (Larotrectinib, Vitrakvi)

Larotrectinib will be administered orally as capsule or liquid solution at a dose of 100 mg twice daily in continuing 28-days cycles.

Trial Locations (98)

0

University of Washington, Seattle

114

Tri-Service General Hospital, Taipei

144

IRCCS Istituti Fisioterapici Ospitalieri - IFO, Rome

810

Royal Darwin Hospital, Tiwi

1070

Institut Jules Bordet/Jules Bordet Instituut, Brussels

2100

Rigshospitalet - Kræftbehandling, Copenhagen OE

2109

Macquarie University Hospital, Sydney

3080

Seoul National University Hospital, Seoul

6008

St John of God Healthcare, Subiaco

6800

Health Ministry Of Türkiye Republic Ankara Bilkent City Hospital, Ankara

8907

Institut Catala D'oncologia - Oncologia, Barcelona

10065

Memorial Sloan Kettering Cancer Center New York - Main Campus, New York

12203

Charité Comprehensive Cancer Center (CCCC), Berlin

19107

Sidney Kimmel Cancer Center - Jefferson Health, Philadelphia

19111

Fox Chase Cancer Center, Philadelphia

20141

Istituto Europeo di Oncologia s.r.l, Milan

22030

Trakya Univ. Tip Fak., Edirne

22031

Inova Schar Cancer Institute, Fairfax

25030

Hopital Jean Minjoz, Besançon

26505

West Virginia University, Morgantown

27157

Wake Forest Baptist Health, Winston-Salem

27514

UNC Hospitals - UNC Lineberger Comprehensive Cancer Center, Chapel Hill

28040

Fundacion Jimenez Diaz (Clinica de la Concepcion), Madrid

28050

Centro Integral Oncológico Clara Campal, Madrid

33000

Institut Bergonie - Unicancer Nouvelle Aquitaine - Service Oncologie medicale, Bordeaux

33026

Memorial Cancer Institute at West, Pembroke Pines

33038

A.S.U. Friuli Centrale - A. Regionale Coordinamento Salute, Udine

34093

Istanbul Universitesi Istanbul Tip Fakultesi, Istanbul

34098

Istanbul Universitesi Cerrahpasa-Cerrahpasa Tip Fakultesi, Istanbul

34722

TC Saglik Bakanligi Goztepe ProfDr Suleyman Yalcin Sehir Has, Istanbul

35128

Istituto Oncologico Veneto, Padua

35360

Izmir Katip Celebi Universitesi Ataturk Egitim ve Arastirma, Izmir

37232

Vanderbilt University Medical Center, Nashville

38039

Erciyes Universitesi Tip Fakultesi, Kayseri

40138

A.O.U. di Bologna Policlinico S.Orsola Malpighi, Bologna

44195

Cleveland Clinic - Neurology, Cleveland

44800

Institut de Cancerologie Ouest - Saint-Herblain, Saint-Herblain

57105

Avera Cancer Institute - Sioux Falls, Sioux Falls

60637

The University of Chicago Medical Center - Hyde Park - Hematology & Oncology, Chicago

67200

ICANS - Institut de Cancerologie de Strasbourg Europe - service oncologie medicale, Strasbourg

75012

Hopital Saint Antoine APHP - Departement Oncologie, Paris

75013

APHP-Hopital la Pitie Salpetriere-Departement oncologie, Paris

77030

The University of Texas MD Anderson Cancer Center - Texas Medical Center, Houston

77900

Fakultní Nemocnice Olomouc, Olomouc

83100

A.O.R.N. San Giuseppe Moscati, Avellino

86021

Hôpital de la Milétrie, Poitiers

90404

UCLA Health Santa Monica Cancer Care, Santa Monica

94304

Stanford Cancer Center Palo Alto, Palo Alto

100142

Beijing Cancer Hospital - Oncology Department, Beijing

111511

Instituto Nacional de Cancerología INC Colombia, Bogota

115478

Russian Oncological Scientific Center n.a. N.N. Blokhin RAMS, Moscow

119991

1st Moscow State Medical University n.a. I.M.Sechenov, Moscow

163045

Arkhangelsk Clinical Oncology Dispensary, Arkhangelsk

168583

National Cancer Center Singapore - Oncology Department, Singapore

197758

St. Petersburg Clinical Onc. Cent. of Spec. Types of Care, Saint Petersburg

200032

Zhongshan Hospital, Fudan University - Oncology Department, Shanghai

230002

Oncomédica S.A., Montería

420029

Republican Clinical Oncology Dispensary Kazan, Kazan'

510000

Sun Yat-sen University Cancer Center, Guangzhou

603006

Clinical Diagnostical Center, Nizhny Novgorod

605006

Jawaharlal Institute Of Postgraduate Medical Education and R, Gorimedu

681004

Fundación Oftalmológica de Santander Carlos Ardila Lule, Floridablanca

751019

All India Institute of Medical Sciences, Bhubaneswar

02114-2696

Mass General Cancer Center, Boston

02215

Dana-Farber Cancer Institute - Oncology Department, Boston

C11118AAT

Hospital Alemán, Buenos Aires

TBC

"Centro Estudios Médicos e Invest. Clínicas Dr. N. Quirno", Buenos Aires

St Vincents University Hospital, Dublin

C1125 ABD

Fundación Cenit para la Investigación en Neurociencias, CABA

C1019ABS

Centro Medico Austral, TBC

T4000HXU

Centro Médico San Roque, San Miguel de Tucumán

74605-070

Hosp. Araujo Jorge da Associação de Combate ao Câncer, Goiânia

30130-090

Cenantron Centro Avançado de Tratamento Oncológico, Ltda., Belo Horizonte

14784-400

Fundacao Pio XII - Hospital de Cancer de Barretos, Barretos/SP

01246-000

Instituto do Cancer do Estado de Sao Paulo, São Paulo

01323-001

Real e Benemérita Associação Portuguesa de Beneficência, São Paulo

03102-002

IBCC - Instituto Brasileiro de Controle do Cancer, São Paulo

20081-250

Instituto Nacional do Câncer - INCA - HC II, Rio de Janeiro

20560-120

INCA - Hospital do Cancer III, Rio de Janeiro

22250-905

Oncoclínicas Rio de Janeiro S.A, Rio de Janeiro

01409-000

Hospital Sirio Libanes, São Paulo

T2N 4N2

Tom Baker Cancer Centre, Calgary

MISSING

Sichuan University West China Hospital, Chengdu

06100

Centre Antoine Lacassagne - Departement Oncologie, Nice

466-8560

Nagoya University Hospital, Nagoya

277-8577

National Cancer Center Hospital East, Kashiwa

060-8648

Hokkaido University Hospital, Sapporo

135-8550

The Cancer Institute Hospital of JFCR, Koto-ku

4200-072

IPO Porto, Porto

812 50

Onkologicky Ustav Svatej Alzbety, s.r.o., Bratislava

833 10

Narodny onkologicky ustav, Bratislava

03722

Severance Hospital, Yonsei University Health System, Seoul

05505

Asan Medical Center - Oncology Department, Seoul

06351

Samsung Medical Center - Oncology Department, Seoul

08003

Hospital del Mar, Barcelona

08035

Ciutat Sanitaria i Universitaria de la Vall d'Hebron, Barcelona

Unknown

"Hospital General Universitario Gregorio Maranon , Oncologia"

171 76

Karolinska Universitetssjukhuset Solna - Tema Cancer, Stockholm

Sponsors

Lead Sponsor

All Listed Sponsors
lead

Bayer

INDUSTRY

NCT02576431 - A Study to Test the Effect of the Drug Larotrectinib in Adults and Children With NTRK-fusion Positive Solid Tumors | Biotech Hunter | Biotech Hunter