Alveolar Recruitment Maneuvers, Intracerebral Hemodynamic and Oxygenation

NARecruitingINTERVENTIONAL
Enrollment

62

Participants

Timeline

Start Date

September 1, 2016

Primary Completion Date

December 31, 2025

Study Completion Date

December 31, 2025

Conditions
Cerebral InjuriesAcute Respiratory Distress Syndrome (ARDS)
Interventions
OTHER

alveolar recruitment maneuvers group 1

"Patients are randomized to receive in cross-over 2 ARM: CPAP at first and then eSigh.~The continuous positive airway pressure, or CPAP with application of a positive pressure of 40 cmH2O for 40 seconds without tidal volume.~The eSigh or extended sigh with increase of PEEP for 10 minutes to maintain plateau pressure at 40 cmH2O. During ARM, the peak pressure is limited to 50 cmH2O with decrease of tidal volume (Vt) if necessary.~The following data: PtiO2, respiratory parameters, systemic and intracerebral hemodynamic parameters are collected before, after 1 minute, 10 minutes and 60 minutes for each ARM."

OTHER

alveolar recruitment maneuvers group 2

"Patients are randomized to receive in cross-over 2 ARM: eSigh at first and then CPAP.~The eSigh or extended sigh with increase of PEEP for 10 minutes to maintain plateau pressure at 40 cmH2O. During ARM, the peak pressure is limited to 50 cmH2O with decrease of tidal volume (Vt) if necessary.~The continuous positive airway pressure, or CPAP with application of a positive pressure of 40 cmH2O for 40 seconds without tidal volume.~The following data: PtiO2, respiratory parameters, systemic and intracerebral hemodynamic parameters are collected before, after 1 minute, 10 minutes and 60 minutes for each ARM."

Trial Locations (5)

31059

RECRUITING

UH Toulouse, Toulouse

34295

RECRUITING

UH Montpellier, Montpellier

44093

RECRUITING

UH Nantes, Nantes

63003

RECRUITING

UH Clermont-Ferrand, Clermont-Ferrand

140033

RECRUITING

UH Caen, Caen

All Listed Sponsors
lead

University Hospital, Toulouse

OTHER