A Study of ABT-414 in Participants With Newly Diagnosed Glioblastoma (GBM) With Epidermal Growth Factor Receptor (EGFR) Amplification

PHASE3CompletedINTERVENTIONAL
Enrollment

691

Participants

Timeline

Start Date

January 4, 2015

Primary Completion Date

April 4, 2022

Study Completion Date

April 4, 2022

Conditions
GlioblastomaGliosarcoma
Interventions
DRUG

Temozolomide

Oral Capsule

DRUG

Depatuxizumab mafodotin

Intravenous (IV) Infusion

RADIATION

Radiation

DRUG

Placebo for ABT-414

IV Infusion (IV)

Trial Locations (212)

100

National Taiwan University Hospital /ID# 143940, Taipei

333

Linkou Chang Gung Memorial Hospital /ID# 143941, Taoyuan

1090

Medizinische Universitaet Wien /ID# 141981, Vienna

1200

UCL Saint-Luc /ID# 141648, Woluwe-Saint-Lambert

1426

Duplicate_Instituto Med Alex Flem /ID# 142884, Buenos Aires

2000

Sanatorio Parque /ID# 142825, Rosario

2031

Duplicate_The Prince of Wales Hospital /ID# 144882, Randwick

2065

Royal North Shore Hospital /ID# 143870, St Leonards

2170

Liverpool Hospital /ID# 144392, Liverpool

2298

Calvary Mater Newcastle /ID# 143860, Waratah

2500

Southern Medical Day Care Centre /ID# 143868, Wollongong

3000

Universitair Ziekenhuis Leuven /ID# 143872, Leuven

3010

Inselspital, Universitätsspital Bern /ID# 141886, Bern

3065

St Vincent's Hospital Melbourne /ID# 143858, Fitzroy Melbourne

3084

Duplicate_Austin Hospital /ID# 143859, Heidelberg

4000

CHU de Liege /ID# 162860, Liège

4020

Kepler Universitätsklinikum GmbH - Neuromed Campus /ID# 141983, Linz

4091

The Oncology Centre /ID# 143950, Durban

4102

Princess Alexandra Hospital /ID# 143857, Woolloongabba

5000

Royal Adelaide Hospital /ID# 143867, Adelaide

5001

Kantonsspital Aarau AG /ID# 141885, Aarau

5006

Calvary North Adelaide Hospita /ID# 143866, Adelaide

5530

Duplicate_UCL Mont Godinne /ID# 141644, Yvoir

6000

Grand Hopital de Charleroi /ID# 141645, Charleroi

6008

St John Of God Subiaco Hospital /ID# 143869, Subiaco

6020

Duplicate_Medizinische Universitat Innsbruck,Universitatsklinik fur Innere Mediz /ID# 141984, Innsbruck

6021

Duplicate_Wellington Hospital (Capital and Coast District Health Board) /ID# 143890, Wellington

6500

Duplicate_EOC Ospedale Regionale di Bellinzona e Valli /ID# 143936, Bellinzona

7100

Duplicate_Centre Hospitalier Jolimont /ID# 143873, La Louvière

7460

Netcare Oncology Intervent Ctr /ID# 143951, Cape Town

7570

Cape Town Oncology Trials /ID# 143948, Kraaifontein

7700

Rondebosch Oncology Center /ID# 143949, Cape Town

8011

Duplicate_Canterbury District Health Boa /ID# 143861, Christchurch

8036

Medizinische Universitaet Graz /ID# 141982, Graz

8091

Universitatsspital Zurich /ID# 141887, Zurich

9000

UZ Gent /ID# 141647, Ghent

9301

University of Free State, Universitas Annex (National Hospital Grounds) /ID# 144064, Bloemfontein

10126

Duplicate_Duplicate_AOU Citta della Salute Scienza /ID# 141801, Turin

10408

National Cancer Center /ID# 141845, Goyang

11217

Taipei Veterans General Hosp /ID# 143955, Taipei

13385

AP-HM - Hopital de la Timone /ID# 143911, Marseille

14642

University of Rochester Medical Center /ID# 144166, Rochester

15212

Allegheny General Hospital /ID# 144126, Pittsburgh

15232

University of Pennsylvania Medical Center - Shadyside /ID# 144159, Pittsburgh

17033

Penn State University and Milton S. Hershey Medical Center /ID# 147525, Hershey

18017

St. Luke's Hospital /ID# 148191, Bethlehem

19111

Fox Chase Cancer Center /ID# 145893, Philadelphia

19713

Christiana Care Health Service /ID# 144127, Newark

20133

Fondazione IRCCS Istituto Neurologico Carlo Besta /ID# 141800, Milan

22042

Inova Health System /ID# 152956, Falls Church

23219

Virginia Commonwealth University Medical Center Main Hospital /ID# 149014, Richmond

28040

Hospital Clinico Universitario San Carlos /ID# 143901, Madrid

28041

Hospital Universitario 12 de Octubre /ID# 143930, Madrid

28050

Hospital Universitario HM Sanchinarro /ID# 143496, Madrid

28204

Levine Cancer Ins, Carolina Me /ID# 144124, Charlotte

29010

Hospital Regional de Malaga /ID# 143902, Málaga

29425

Medical University of South Carolina /ID# 144141, Charleston

30309

Piedmont Hospital /ID# 145892, Atlanta

30322

Emory Midtown Infectious Disease Clinic /ID# 144015, Atlanta

32803

Advent Health /ID# 144128, Orlando

33176

Baptist Hospital Miami /ID# 152451, Miami

33308

Holy Cross Hospital /ID# 156764, Fort Lauderdale

33486

Boca Raton Regional Hospital /ID# 163659, Boca Raton

35128

Istituto Oncologico Veneto /ID# 143821, Padua

43210

The Ohio State University /ID# 144016, Columbus

43614

University of Toledo /ID# 156763, Toledo

44106

Duplicate_Univ Hosp Cleveland /ID# 144153, Cleveland

44195

Cleveland Clinic Main Campus /ID# 144023, Cleveland

44791

Universitaetsklinikum Knappschaftskrankenhaus Bochum GmbH /ID# 143961, Bochum

44805

Institut de Cancérologie de l'Ouest René Gauducheau /ID# 143914, Saint-Herblain

46014

Hospital General Universitario de Valencia /ID# 143903, Valencia

46805

Parkview Research Ctr, Hosp /ID# 144150, Fort Wayne

48197

Duplicate_St. Joseph Mercy Hospital /ID# 144143, Ypsilanti

48202

Henry Ford Health System /ID# 145896, Detroit

49933

Insititut de Cancerologie /ID# 143908, Angers

50034

Hospital Pablo Tobon Uribe /ID# 143780, Medellín

55416

Mmcorc /Id# 144146, Saint Louis Park

59037

CHRU Lille - Hopital Claude Huriez /ID# 143915, Lille

60201

NorthShore University HealthSystem /ID# 144017, Evanston

60555

Northwestern Medicine Cancer Center - Warrenville /ID# 148476, Warrenville

63110

Washington University-School of Medicine /ID# 144174, St Louis

66000

Oncologos del Occidente S.A /ID# 147713, Pereira

66278

Centro Medico Zambrano Hellion /ID# 143845, San Pedro Garza García

68114

Nebraska Methodist Hospital /ID# 144140, Omaha

68198

University of Nebraska Medical Center /ID# 145899, Omaha

69120

Universitaetsklinik Heidelberg /ID# 143927, Heidelberg

72076

Universitaetsklinikum Tuebingen /ID# 143926, Tübingen

72762

Highlands Oncology Group, PA /ID# 142050, Springdale

73104

Univ Oklahoma HSC /ID# 144161, Oklahoma City

75013

Hopital Pitie Salpetriere /ID# 143917, Paris

75246

Baylor Sammons Cancer Center /ID# 155542, Dallas

76508

Duplicate_Scott and White Medical Center /ID# 160743, Temple

77030

The University of Texas Health Science Center at Houston /ID# 144013, Houston

University of Texas MD Anderson Cancer Center /ID# 144018, Houston

78758

Austin Cancer Centers /ID# 151061, Austin

80045

Univ of Colorado Cancer Center /ID# 148194, Aurora

85013

St. Josephs Hospital and Med Center /ID# 144149, Phoenix

90033

University of Southern California /ID# 147543, Los Angeles

90048

Cedars-Sinai Medical Center-West Hollywood /ID# 148472, West Hollywood

90095

University of California, Los Angeles /ID# 149239, Los Angeles

90404

Duplicate_St. John's Health Center /ID# 148192, Santa Monica

91120

Gastroenterology Institute, Division of Medicine /ID# 143958, Jerusalem

92123

Sharp Memorial Hospital /ID# 148193, San Diego

93000

Hopital Avicenne - APHP /ID# 143910, Bobigny

94805

Duplicate_Gustave Roussy /ID# 143912, Villejuif

98101

Virginia Mason Medical Center /ID# 144022, Seattle

98109

University of Washington /ID# 144162, Seattle

100042

SanboBrain Hospital Capital Medical University /ID# 166422, Beijing

100070

Beijing Tian Tan Hospital, Capital Medical University /ID# 167160, Beijing

100730

Peking Union Medical College Hospital /ID# 157430, Beijing

110004

Duplicate_Shengjing Hospital of China Medical University /ID# 167016, Shenyang

110221

Administradora del Country_S.A-Clinica Del Country /ID# 143881, Bogota

115478

Federal State Budgetary Scientific Institution N.N. Blokhin /ID# 141707, Moscow

119074

National University Hospital /ID# 143933, Singapore

125047

National Medical Research Center for Neurosurgery n.a. N. N. Burdenko /ID# 141701, Moscow

125367

Federal State Treatment and Rehabilitation center /ID# 141704, Moscow

129090

GEMC - European Medical Center /ID# 141703, Moscow

169610

National Cancer Ctr Singapore /ID# 143932, Singapore

200040

Duplicate_Huashan Hospital of Fudan University /ID# 159999, Shanghai

215006

The First Affiliated Hospital of Soochow University /ID# 165596, Suzhou

230001

Anhui Provincial Hospital /ID# 166320, Hefei

230002

Instituto Medico de Alta Tecnologia Oncomédica S.A /ID# 147223, Montería

236016

Regional Clinical Hospital of Kaliningrad region /ID# 141702, Kaliningrad

300052

Duplicate_Tianjin Med Univ General Hosp /ID# 143923, Tianjin

310009

Duplicate_The Second Affiliated Hospital of ZUSM /ID# 165593, Hangzhou

350005

The First Affiliated Hospital of Fujian Medical University /ID# 159166, Fuzhou

410008

Duplicate_Xiangya Hospital Central South University /ID# 166791, Changsha

430030

Tongji Hospital Tongji Medical College of HUST /ID# 163820, Wuhan

450054

State budgetary healthcare institution Republican Clinical Oncology Dispensary /ID# 141706, Ufa

510060

Sun Yat-Sen University Cancer Center /ID# 143919, Guangzhou

620043

Sverdlovsk Regional Oncology Dispensary /ID# 141700, Yekaterinburg

710038

Duplicate_Tangdu Hospital /ID# 143920, Xi'an

999077

Prince of Wales Hospital /ID# 143952, Hong Kong

3109601

Rambam Health Care Campus /ID# 143959, Haifa

4941492

Rabin Medical Center /ID# 143957, Petah Tikva

5265601

The Chaim Sheba Medical Center /ID# 143960, Ramat Gan

6423906

Tel Aviv Sourasky Medical Center /ID# 143956, Tel Aviv

94143-2204

Univ California, San Francisco /ID# 145889, San Francisco

06824

Associated Neurologists of Sou /ID# 147701, Fairfield

06510

Yale University /ID# 144170, New Haven

33612-9416

Moffitt Cancer Center /ID# 144130, Tampa

60611-2927

Northwestern University Feinberg School of Medicine /ID# 147895, Chicago

60637-1443

The University of Chicago Medical Center /ID# 144158, Chicago

66205-2003

Univ Kansas Cancer Ctr - Overl /ID# 145895, Westwood

04074

Maine Medical Partners Neurolo /ID# 160864, Scarborough

02111-1552

Tufts Medical Center /ID# 145897, Boston

02114

Massachusetts General Hospital /ID# 144145, Boston

02215

Dana-Farber Cancer Institute /ID# 148475, Boston

48201-2013

Wayne State University /ID# 145890, Detroit

08103

MD Anderson Cancer Center at Cooper - Camden /ID# 145891, Camden

08901

Rutgers Cancer Institute of New Jersey /ID# 148190, New Brunswick

10032-3729

Columbia University Medical Center /ID# 144020, New York

45267-0585

University of Cincinnati /ID# 144164, Cincinnati

19104-5502

University of Pennsylvania /ID# 157623, Philadelphia

19107-4414

Thomas Jefferson University /ID# 144191, Philadelphia

84107-5701

Intermountain Medical Center /ID# 144142, Murray

84112-5500

University of Utah /ID# 144160, Salt Lake City

53792-0001

Univ of Wisconsin Hosp/Clinics /ID# 144167, Madison

53226-3522

Froedtert Memorial Lutheran Hospital /ID# 144139, Milwaukee

59075-740

Liga Norte Riograndense Contra o Câncer /ID# 143878, Natal

90610-000

Hospital Sao Lucas da PUCRS /ID# 143879, Porto Alegre

14784-400

Fundacao Pio XII - Hospital de Cancer de Barretos /ID# 143876, Barretos

01246-000

Instituto do Câncer do Estado de São Paulo - ICESP /ID# 144031, São Paulo

20231-050

Instituto Nacional de Câncer José Alencar Gomes da Silva (INCA) /ID# 143877, Rio de Janeiro

R3E 0V9

Duplicate_Cancer Care Manitoba /ID# 149253, Winnipeg

B3H 1V7

QE II Health Sciences Centre /ID# 151600, Halifax

L8V 1C3

Juravinski Cancer Centre /ID# 152117, Hamilton

N6A 4L6

Victoria Hospital /ID# 144184, London

K1H 8L6

Ottawa Hospital Research Institute /ID# 150120, Ottawa

M5G 2M9

Princess Margaret Cancer Centre /ID# 166277, Toronto

H1T 2M4

Duplicate_Hospital Maisonneuve-Rosemont /ID# 149315, Montreal

H2X 0A9

CHUM - Notre-Dame Hospital /ID# 144027, Montreal

H3T 1E2

Duplicate_Jewish General Hospital /ID# 144029, Montreal

H4A 3J1

Royal Victoria Hospital / McGill University Health Centre /ID# 144187, Montreal

G1R 2J6

CHU de Quebec-Universite Laval /ID# 144189, Québec

J1H 5N4

CHUS - Hopital Fleurimont /ID# 149771, Sherbrooke

Unknown

Centro Medico Imbanaco de Cali /ID# 143882, Santiago de Cali

656 53

Masarykuv onkologicky ustav /ID# 143884, Brno

500 05

Duplicate_FN Hradec Kralove /ID# 143885, Hradec Králové

460 01

Krajska nemocnice Liberec, a.s. /ID# 142024, Liberec

708 52

Duplicate_Univ Hosp Ostrava-Poruba /ID# 143883, Ostrava

150 06

Fakultni Nemocnice v Motole /ID# 142023, Prague

06002

CHU Nice -Hopital Pasteur /ID# 143916, Nice

04103

Universitaetsklinikum Leipzig /ID# 143962, Leipzig

D09 XR63

Beaumont Hospital /ID# 142969, Beaumont

00144

Duplicate_Regina Elena National Cancer I /ID# 141795, Rome

1081 HV

Vrije Universiteit Medisch Centrum /ID# 143889, Amsterdam

9713 GZ

Universitair Medisch Centrum Groningen /ID# 141408, Groningen

6229 HX

Maastricht Universitair Medisch Centrum /ID# 143585, Maastricht

2512 VA

Haaglanden Medisch Centrum /ID# 141405, The Hague

3584 CX

Universitair Medisch Centrum Utrecht /ID# 141406, Utrecht

4710-243

CCA Braga - Hospital de Braga /ID# 141940, Braga

8000-386

Centro Hospitalar Universitário do Algarve, EPE - Hospital Faro /ID# 141939, Faro

1099-023

IPO Lisboa FG, EPE /ID# 141938, Lisbon

1649-035

Centro Hospitalar Universitario de Lisboa Norte, EPE - Hospital de Santa Maria /ID# 141941, Lisbon

4200-319

Centro Hospitalar Universitario de Sao Joao, EPE /ID# 142830, Porto

0140

Netcare Unitas Hospital /ID# 152936, Centurion

03722

Duplicate_Yonsei University Health System, Severance hospital. /ID# 141846, Seoul

03080

Seoul National University Hospital /ID# 143886, Seoul

06351

Samsung Medical Center /ID# 143887, Seoul

06591

The Catholic University of Korea, Seoul St. Mary's Hospital /ID# 141844, Seoul

08036

Hospital Clinic de Barcelona /ID# 143906, Barcelona

08041

Hospital Santa Creu i Sant Pau /ID# 143900, Barcelona

SE1 9RT

Guys and St Thomas NHS Foundation Trust /ID# 142652, London

B15 2TH

University Hospitals Birmingham NHS Foundation Trust /ID# 154592, Birmingham

CF15 7QZ

Velindre University NHS Trust /ID# 141996, Cardiff

DD2 1UB

Duplicate_NHS Tayside /ID# 141651, Dundee

EH3 9HE

NHS Lothian /ID# 141802, Edinburgh

LS9 7TF

Leeds Teaching Hospitals NHS Trust /ID# 141653, Leeds

NW1 2PG

University College London Hospitals NHS Foundation Trust /ID# 142658, London

NE7 7DN

Duplicate_The Newcastle Upon Tyne Hospitals NHS Foundation Trust /ID# 141999, Newcastle upon Tyne

SM2 5PT

Royal Marsden Hospital /ID# 142827, Sutton

Sponsors

Lead Sponsor

All Listed Sponsors
collaborator

Radiation Therapy Oncology Group

NETWORK

lead

AbbVie

INDUSTRY