Cross-linking for Corneal Ulcers Treatment Trial

PHASE3CompletedINTERVENTIONAL
Enrollment

147

Participants

Timeline

Start Date

November 30, 2015

Primary Completion Date

June 18, 2018

Study Completion Date

March 19, 2019

Conditions
Corneal UlcerInfectious KeratitisBacterial UlcerFungal Ulcer
Interventions
PROCEDURE

Corneal Cross-linking

For those subjects randomized to receive collagen cross-linking, the procedure will be performed as per the routine at the hospital (UV-X machine; strict aseptic precautions; corneal epithelium debrided and 0.1% riboflavin applied for 30 minutes, then UV-A radiation applied for 30 minutes at 370nm with 3mW/cm2). Corneal cross-linking is a routine procedure performed by Aravind Eye Hospital for infectious keratitis.

DRUG

Anti Fungal Drug

Topical Amphotericin B vs Topical Natamycin

Trial Locations (2)

94143

Proctor Foundation, UCSF, San Francisco

Unknown

Aravind Eye Hospitals, Madurai

All Listed Sponsors
collaborator

Aravind Eye Hospitals, India

OTHER

lead

University of California, San Francisco

OTHER

NCT02570321 - Cross-linking for Corneal Ulcers Treatment Trial | Biotech Hunter | Biotech Hunter