Standard vs. Accelerated Initiation of RRT in Acute Kidney Injury (STARRT-AKI: Principal Trial)

NACompletedINTERVENTIONAL
Enrollment

3,019

Participants

Timeline

Start Date

October 31, 2015

Primary Completion Date

December 31, 2019

Study Completion Date

December 31, 2019

Conditions
Acute Kidney Injury
Interventions
OTHER

Standard RRT initiation

"In the absence of kidney function recovery, the initiation of RRT will be permitted if one of the following develops:~serum potassium ≥ 6.0 mmol/L; pH ≤ 7.20 or serum bicarbonate ≤ 12 mmol/L; evidence of severe respiratory failure, based on a PaO2/FiO2 ≤ 200 and clinical perception of volume overload; and/or persistent AKI \> 72 hours following the time of randomization."

OTHER

Accelerated RRT initiation

A dialysis catheter will be placed and RRT initiated as soon as possible and within 12 hours of eligibility. This 12 hour window includes the time needed to obtain consent.

Trial Locations (105)

1011

Centre Hospitalier Universitaire Vaudois (CHUV), Lausanne

1090

Vienna General Hospital, Vienna

1148

Auckland City Hospital, Grafton

2010

St. Vincent's Hospital, Sydney

2065

Royal North Shore Hospital, Sydney

2139

Concord Hospital, Concord

2650

Antwerp University Hospital, Edegem

3076

The Northern Hospital, Epping

3084

Austin Hospital, Heidelberg

3220

Geelong Hospital, Geelong

3350

Ballarat Hospital, Ballarat

3550

Bendigo Hospital, Bendigo

5042

Flinder Medical Centre, Bedford Park

6021

Wellington Hospital, Wellington

8011

Christchurch Hospital, Christchurch

8036

Medical University Graz, Graz

20132

San Raffaele Hospital, Milan

20521

Turku University Hospital, Turku

32611

University of Florida, Gainesville

33521

Tampere University Hospital, Tampere

35294

University of Alabama at Birmingham, Birmingham

40506

University of Kentucy, Lexington

48149

University Hospital Münster, Münster

55905

Mayo Clinic, Rochester

92700

Hopital Louis Mourier, Colombes

96450

Klinikum Coburg, Coburg

02903

Rhode Island Hospital, Providence

02906

The Miriam Hospital, Providence

Unknown

Eastern Hospital (Box Hill and Maroondah Hospital), Box Hill

The Alfred Hospital, Melbourne

Royal Prince Alfred Hospital, Sydney

Princess Alexandra Hospital, Woolloongabba

Medical University Innsbruck, Innsbruck

Ghent University Hospital, Ghent

Hospital de Clínicas de Porto Alegre - Rio Grande do Sul, Rio Branco

Foothills Hospital, Calgary

Grey Nuns Community Hospital, Edmonton

Royal Alexandra Hospital, Edmonton

St. Paul's Hospital - Providence Health Care, Vancouver

Health Sciences Centre, Winnipeg

Health Sciences North, Greater Sudbury

Hamilton General Hospital, Hamilton

Juravinski Hospital, Hamilton

St. Joseph's Healthcare Hamilton, Hamilton

Kingston General Hospital, Kingston

London Health Sciences Centre, University Hospital, London

London Health Sciences Centre, Victoria Hospital, London

Trillium Health Partners - Credit Valley Hospital, Mississauga

Trillium Health Partners - Mississauga Hospital, Mississauga

The Ottawa Hospital, Civic Campus, Ottawa

The Ottawa Hospital, General Campus, Ottawa

Mount Sinai Hospital, Toronto

St. Michael's Hospital, Toronto

Sunnybrook Health Sciences Centre, Toronto

Toronto General Hospital, Toronto

Toronto Western Hospital, Toronto

Centre hospitalier de l'université de Montréal (Notre Dame), Montreal

Centre hospitalier de l'université de Montréal (St. Luc), Montreal

CHUM - Hôtel Dieu Montreal, Montreal

Hopital Maisonneuve-Rosemont, Montreal

McGill University Health Centre (MUHC), Montreal

Centre Hospitalier Universitaire de Quebec (CHUQ), Québec

Centre Hôspitalier universitaire de Sherbrooke (CHUS), Sherbrooke

Centre de sante et de services sociaux de Trois-Rivieres (CIUSSS MCQ), Trois-Rivières

Regina Qu'Appelle Health Region, Saskatoon

Beijing Friendship Hospital, Capital Medical University, Beijing

Peking Union Medical College Hospital, Beijing

The First Hospital of Jilin University, Changchun

Xiangya Hospital Central South University, Changsha

Guizhou Provincial People's Hospital, Guiyang

Shandong Provincial Hospital, Jinan

Zhongda Hospital Southeast University, Nanjing

Renmin Hospital of Wuhan University, Wuhan

Zhongnan Hospital of Wuhan University, Wuhan

The First Affiliated Hospital of Xi'An Jiaotong University, Xi'an

The First Affiliated Hospital of Xiamen University, Xiamen

Henan Provincial People's Hospital, Zhengzhou

St. Vincent's University Hospital, Dublin

Auckland Hospital DCCM, Auckland

Hawke's Bay Hospital, Hastings

Rotorua Hospital, Rotorua

Leeds Teaching Hospital, Leeds

Guy's and St. Thomas Hospital, London

NSW 2747

Nepean Hospital, Kingswood

QLD 4560

Nambour General Hospital, Nambour

VIC 3021

Western Health (Footscray Hospital & Sunshine Hospital), St Albans

T1Y 6J4

Peter Lougheed Centre, Calgary

T5R 4H5

Misericordia Community Hospital, Edmonton

T6G 2B7

Mazankowski Alberta Heart Institute, Edmonton

University of Alberta Hospital, Edmonton

T4N 4E7

Red Deer Regional Hospital, Red Deer

T8N 6C4

Sturgeon Community Hospital, St. Albert

V3V 1Z2

Surrey Memorial Hospital, Fraser Health, Surrey

V8R 1J8

Royal Jubilee Hospital, Victoria

V8Z 6R5

Victoria General Hospital, Victoria

A1B 3X9

Memorial University of Newfoundland, St. John's

L1G 2B9

Lakeridge Health, Oshawa

G1V 4G5

Institut Universitaire de Cardiologie et de Pneumologie de Québec- Université Laval (IUCPQ), Québec

00290

Helsinki University Central Hospital, Helsinki

HP21 8AL

Stoke Mandeville Hospital, Aylesbury

HP11 2TT

Wycombe General Hospital, High Wycombe

SE13 6LH

Lewisham Hospital, London

SE5 9RS

King's College Hospital, London

NG5 1PB

Nottingham University Hospital, Nottingham

BR6 8ND

Princess Royal University Hospital, Orpington

All Listed Sponsors
collaborator

Canadian Institutes of Health Research (CIHR)

OTHER_GOV

collaborator

National Health and Medical Research Council, Australia

OTHER

collaborator

Baxter Healthcare Corporation

INDUSTRY

collaborator

The George Institute

OTHER

collaborator

National Institute for Health Research, United Kingdom

OTHER_GOV

collaborator

Medical Research Institute of New Zealand

OTHER

collaborator

Health Research Council, New Zealand

OTHER

lead

Unity Health Toronto

OTHER