Basket Study of Entrectinib (RXDX-101) for the Treatment of Patients With Solid Tumors Harboring NTRK 1/2/3 (Trk A/B/C), ROS1, or ALK Gene Rearrangements (Fusions)

PHASE2Active, not recruitingINTERVENTIONAL
Enrollment

534

Participants

Timeline

Start Date

November 19, 2015

Primary Completion Date

December 31, 2025

Study Completion Date

December 31, 2025

Conditions
Breast CancerCholangiocarcinomaColorectal CancerHead and Neck NeoplasmsLymphoma, Large-Cell, AnaplasticMelanomaNeuroendocrine TumorsNon-Small Cell Lung CancerOvarian CancerPancreatic CancerPapillary Thyroid CancerPrimary Brain TumorsRenal Cell CarcinomaSarcomasSalivary Gland CancersAdult Solid Tumor
Interventions
DRUG

Entrectinib

TrkA/B/C, ROS1, and ALK inhibitor

Trial Locations (128)

128

Università Campus Bio-Medico di Roma, Rome

2170

Liverpool Hospital, Liverpool

2305

Newcastle Private Hospital, Newcastle

2650

Antwerp University Hospital, Edegem

3084

Austin Health, Heidelberg

5042

Flinders Medical Centre, Bedford Park

6132

Azienda Ospedaliera di Perugia Ospedale S. Maria della Misericordia, Perugia

6519

Yale University, New Haven

10022

Memorial Sloan Kettering Cancer Center, New York

11217

Taipei Veterans General Hospital, Taipei

11733

North Shore Hem Onc Associates, East Setauket

13125

Evang. Lungenklinik Berlin Klinik für Pneumologie, Berlin

13385

Hôpital de la Timone, Marseille

13915

Hôpital Nord - AP-HM Marseille#, Marseille

20007

Georgetown University Medical Center Lombardi Cancer Center, Washington D.C.

20133

Fondazione IRCCS Istituto Nazionale dei Tumori, Milan

20162

Azienda Socio Sanitaria Territoriale Niguarda (Ospedale Niguarda Ca' Granda), Milan

21237

Weinberg Cancer Institution at Franklin Square, Baltimore

22031

Virginia Cancer Specialists, PC, Fairfax

23502

Virginia Oncology Associates - Hampton, Norfolk

27710

Duke Cancer Institute, Durham

28034

Hospital Universitario Ramon y Cajal, Madrid

28040

Hospital Universitario Clínico San Carlos, Madrid

28041

Hospital Universitario 12 de Octubre, Madrid

28046

Hospital Universitario La Paz, Madrid

28204

Levine Cancer Institute, Charlotte

28942

Centro Nacional de Investigaciones Oncológicas(CNIO), Fuenlabrada

29010

Hospital Clinico Universitario Virgen de la Victoria, Málaga

30265

Southeastern Regional Medical Center, Inc., Newnan

30322

Winship Cancer Institute, Atlanta

30607

University Cancer & Blood Center, LLC, Athens

31059

Institut Claudius Regaud, Toulouse

33076

Institut Bergonie, Bordeaux

34090

Institut de Recherche en Cancérologie de Montpellier, Montpellier

34232

Florida Cancer Specialists - Sarasota, Sarasota

35128

IOV - Istituto Oncologico Veneto - IRCCS, Padua

37075

Universitaetsmedizin Goettingen, Göttingen

41013

Hospital Universitario Virgen del Rocio, Seville

43210

Ohio State University, Columbus

OSU, James Cancer Hospital, Columbus

44805

Institut De Cancerologie De L'ouest - Rene Gauducheau - Biology, Saint-Herblain

48109

University of Michigan Comprehensive Cancer Center, Ann Arbor

48201

Karmanos Cancer Center, Detroit

48202

Henry Ford Hospital, Detroit

49055

Institut de Cancerologie de l Ouest, Angers

50937

Universitaetsklinikum Koeln, Cologne

55455

Regents of the University of Minnesota, Minneapolis

56126

Azienda Ospedaliero Universitaria Pisana, Pisa

60068

Advocate Medical Group - Park Ridge, Luther Lane - Oncology, Park Ridge

60099

Midwestern Regional Medical Center, Zion

60611

Northwestern University, Chicago

63128

Washington University, St Louis

69120

NCT Uniklinikum Heidelberg, Heidelberg

69373

Centre Leon Berard, Lyon

70457

National Cheng Kung University Hospital, Tainan City

74133

Cancer Treatment Centers of America, Tulsa

75005

Institut Curie, Paris

75230

Mary Crowley Medical Research Center, Dallas

76508

Baylor Scott & White Health, Temple

77030

University of Texas MD Anderson Cancer Center, Houston

80045

University of Colorado Cancer Center, Aurora

80131

Seconda Università degli Studi di Napoli, Napoli

84112

University of Utah Hospitals & Clinics, Salt Lake City

85013

Dignity Health St Joseph's Hospital and Medical Center, Phoenix

85054

Mayo Clinic, Phoenix

89169

Comprehensive Cancer Centers of Nevada (CCCN) - Central Valley, Las Vegas

90027

Southern California Kaiser Permanente, Los Angeles

90032

University of Southern California Medical Center, Los Angeles

90403

Sarcoma Oncology Center, Santa Monica

Sarcoma Oncology Research Center LLC, Santa Monica

91010

City of Hope Cancer Center, Duarte

City of Hope Duarte - Comprehensive Cancer Center, Investigational Drug Services, Duarte

92037

Scripps Clinic, La Jolla

92093

University of California San Diego Moores Cancer Center, La Jolla

92868

Univ Of California Irvine College Of Medicine, Orange

94115

UCSF Mount Zion Medical Ctr, San Francisco

94158

UCSF Mission Bay, San Francisco

94805

Institut Gustave Roussy, Villejuif

97239

Oregon Health & Science Univ, Portland

98109

University of Washington Seattle Cancer Care Alliance, Seattle

100142

Beijing Cancer Hospital, Beijing

119228

National University Hospital, Singapore

123456

The Chinese University of Hong Kong, Shatin

150081

Harbin Medical University Cancer Hospital, Harbin

169610

National Cancer Centre, Singapore

200030

Shanghai chest hospital, Shanghai

200120

Fudan University Shanghai Cancer Center, Shanghai

310022

Zhejiang Cancer Hospital, Hangzhou

430023

Union Hospital Tongji Medical College Huazhong University of Science and Technology, Wuhan

510000

Cancer Center of Guangzhou Medical University, Guangzhou

510852

Shenzhen People's Hospital, Shenzhen

610041

Sichuan Provincial Cancer Hospital, Chengdu

33612-9497

H. Lee Moffitt Cancer Center and Research Inst., Tampa

02114

Massachusetts General Hosp CAR, Boston

Massachusetts General Hospital, Boston

02215

Beth Israel Deaconess Medical Center, Boston

Dana Farber Cancer Institute, Boston

97239-3098

Oregon Health & Science University, Portland

01307

Universitaetsklinikum Carl Gustav Carus TU Dresden, Dresden

Unknown

Princess Margaret Hospital, Hong Kong

The University of Hong Kong, Hong Kong

Queen Elizabeth Hospital, Kowloon

464-8681

Aichi Cancer Center Hospital, Aichi

104-0045

National Cancer Center Hospital, Chūō

811-1395

NHO Kyushu Cancer Center, Fukuoka

673-8558

Hyogo Cancer Center, Dept of Respiratory Medicine, Hyōgo

277-8577

National Cancer Center Hospital, Kashiwa-shi

791-0280

NHO Shikoku Cancer Center, Matsuyama

981-1293

Miyagi Cancer Center, Miyagi

951-8566

Niigata Cancer Center Hospital, Niigata

534-0021

Osaka City General Hospital, Osaka

589-8511

Kindai University Hospital, Osaka

411-8777

Shizuoka Cancer Center, Shizuoka

1066 CX

NKI The Netherlands Cancer Institute, Amsterdam

2333 ZA

Leids Universitair Medisch Centrum, Leiden

80-214

Uniwersyteckie Centrum Kliniczne, Gdansk

44-101

Centrum Onkologii-Instytut im.M.Sklodowskiej Curie, Gliwice

60-569

Szpital Kliniczny Przemienienia Panskiego Uni. Medycznego im. Karola Marcinkowskiego, Późna

02-781

Centrum Onkologii Instytut im. M. Sklodowskiej-Curie, Klinika Nowotworow Ukladu Chlonnego, Warsaw

03080

Seoul National University Hospital, Seoul

05505

Asan Medical Center., Seoul

06351

Samsung Medical Center, Seoul

120-752

Severance Hospital, Yonsei University Health System, Seoul

08035

Vall d?Hebron Institute of Oncology (VHIO), Barcelona, Barcelona

00100

National Taiwan University Hospital, Taipei

CB2 0QQ

Addenbrookes Hospital, Cambridge

W1G 6AD

Sarah Cannon Research Institute, London

M20 4BX

The Christie, Manchester

All Listed Sponsors
lead

Hoffmann-La Roche

INDUSTRY