Evaluating the Safety and Efficacy of the VRC01 Antibody in Reducing Acquisition of HIV-1 Infection in Women

PHASE2CompletedINTERVENTIONAL
Enrollment

1,924

Participants

Timeline

Start Date

May 31, 2016

Primary Completion Date

March 3, 2021

Study Completion Date

March 3, 2021

Conditions
HIV Infections
Interventions
BIOLOGICAL

VRC01

Administered by IV infusion; total dose will vary based on participant's weight

BIOLOGICAL

Placebo for VRC01

Sodium Chloride for Injection USP, 0.9%; administered by IV infusion

Trial Locations (21)

1632

The Aurum Institute Tembisa Clinical Research Centre CRS, Johannesburg

1862

Soweto HVTN CRS, Johannesburg

2001

Ward 21 CRS, Johannesburg

2038

Wits Reproductive Health and HIV Institute CRS (WRHI CRS), Johannesburg

2571

Aurum Institute Klerksdorp CRS, Klerksdorp

3660

Botha's Hill CRS, Durban

4013

CAPRISA eThekwini CRS, Durban

Vulindlela CRS, Durban

4030

Chatsworth CRS, Chatsworth

7925

Groote Schuur HIV CRS, Cape Town

40100

Kisumu Crs, Kisumu

Unknown

Gaborone CRS, Gaborone

Blantyre CRS, Blantyre

Malawi CRS, Lilongwe

Polana Canico Health Research and Training Center (CISPOC), National Institute of Health (INS) CRS, Maputo

National Institute for Medical Research (NIMR) - Mbeya Medical Research Center (MMRC) Network CRS, Mbeya

Seke South CRS, Chitungwiza

Milton Park CRS, Harare

Spilhaus CRS, Harare

0122

Synexus Stanza Clinical Research Centre CRS, Pretoria

0300

Rustenburg CRS, Rustenburg

All Listed Sponsors
lead

National Institute of Allergy and Infectious Diseases (NIAID)

NIH

NCT02568215 - Evaluating the Safety and Efficacy of the VRC01 Antibody in Reducing Acquisition of HIV-1 Infection in Women | Biotech Hunter | Biotech Hunter