325
Participants
Start Date
June 1, 2016
Primary Completion Date
June 30, 2023
Study Completion Date
October 16, 2025
Cyclophosphamide
Given IV and PO
Dactinomycin
Given IV
Irinotecan Hydrochloride
Given IV
Laboratory Biomarker Analysis
Correlative studies
Questionnaire Administration
Ancillary studies
Radiation Therapy
Undergo RT
Temsirolimus
Given IV
Vincristine Sulfate
Given IV
Vinorelbine
Given IV
Starship Children's Hospital, Grafton
Sydney Children's Hospital, Randwick
The Children's Hospital at Westmead, Westmead
John Hunter Children's Hospital, Hunter Regional Mail Centre
Queensland Children's Hospital, South Brisbane
Princess Margaret Hospital for Children, Perth
Perth Children's Hospital, Perth
Christchurch Hospital, Christchurch
Laura and Isaac Perlmutter Cancer Center at NYU Langone, New York
Mount Sinai Hospital, New York
NYP/Columbia University Medical Center/Herbert Irving Comprehensive Cancer Center, New York
Memorial Sloan Kettering Cancer Center, New York
Montefiore Medical Center-Einstein Campus, The Bronx
Montefiore Medical Center-Weiler Hospital, The Bronx
Children's Hospital at Montefiore, The Bronx
Montefiore Medical Center - Moses Campus, The Bronx
New York Medical College, Valhalla
Westchester Medical Center, Valhalla
The Steven and Alexandra Cohen Children's Medical Center of New York, New Hyde Park
Maimonides Medical Center, Brooklyn
NYU Langone Hospital - Long Island, Mineola
Stony Brook University Medical Center, Stony Brook
Albany Medical Center, Albany
Glens Falls Hospital, Glens Falls
State University of New York Upstate Medical University, Syracuse
Roswell Park Cancer Institute, Buffalo
University of Rochester, Rochester
Children's Hospital of Pittsburgh of UPMC, Pittsburgh
Penn State Children's Hospital, Hershey
Geisinger Medical Center, Danville
Lehigh Valley Hospital - Muhlenberg, Bethlehem
Lehigh Valley Hospital-Cedar Crest, Allentown
Children's Hospital of Philadelphia, Philadelphia
Saint Christopher's Hospital for Children, Philadelphia
Alfred I duPont Hospital for Children, Wilmington
Kaiser Permanente-Capitol Hill Medical Center, Washington D.C.
MedStar Georgetown University Hospital, Washington D.C.
Children's National Medical Center, Washington D.C.
Sibley Memorial Hospital, Washington D.C.
University of Maryland/Greenebaum Cancer Center, Baltimore
Sinai Hospital of Baltimore, Baltimore
Johns Hopkins University/Sidney Kimmel Cancer Center, Baltimore
Inova Fairfax Hospital, Falls Church
University of Virginia Cancer Center, Charlottesville
VCU Massey Comprehensive Cancer Center, Richmond
Children's Hospital of The King's Daughters, Norfolk
West Virginia University Charleston Division, Charleston
WVUH-Berkely Medical Center, Martinsburg
Camden Clark Medical Center, Parkersburg
United Hospital Center, Bridgeport
West Virginia University Healthcare, Morgantown
Wake Forest University Health Sciences, Winston-Salem
UNC Lineberger Comprehensive Cancer Center, Chapel Hill
Duke University Medical Center, Durham
East Carolina University, Greenville
Novant Health Cancer Institute - Huntersville, Huntersville
Novant Health Presbyterian Medical Center Huntersville, Huntersville
Southern Oncology Specialists-Huntersville, Huntersville
Matthews Radiation Oncology Center, Matthews
Novant Health Cancer Institute - Matthews, Matthews
Novant Health Cancer Institute - Mooresville, Mooresville
Novant Health Cancer Institute - Rowan, Salisbury
Rowan Regional Medical Center, Salisbury
Carolinas Medical Center/Levine Cancer Institute, Charlotte
Novant Health Presbyterian Medical Center, Charlotte
Novant Health Carolina Surgical - Randolph, Charlotte
Oncology Specialists of Charlotte, Charlotte
Southern Oncology Specialists-Charlotte, Charlotte
Mission Hospital, Asheville
Prisma Health Richland Hospital, Columbia
Prisma Health Cancer Institute - Spartanburg, Boiling Springs
Prisma Health Cancer Institute - Laurens, Clinton
Medical University of South Carolina, Charleston
Saint Francis Hospital, Greenville
BI-LO Charities Children's Cancer Center, Greenville
Prisma Health Cancer Institute - Butternut, Greenville
Prisma Health Cancer Institute - Faris, Greenville
Saint Francis Cancer Center, Greenville
Prisma Health Cancer Institute - Eastside, Greenville
Prisma Health Cancer Institute - Easley, Easley
Prisma Health Cancer Institute - Greer, Greer
Prisma Health Cancer Institute - Seneca, Seneca
Children's Healthcare of Atlanta - Arthur M Blank Hospital, Atlanta
Augusta University Medical Center, Augusta
Atrium Health Navicent, Macon
Memorial Health University Medical Center, Savannah
Nemours Children's Clinic-Jacksonville, Jacksonville
Nemours Children's Clinic - Pensacola, Pensacola
Sacred Heart Hospital, Pensacola
University of Florida Health Science Center - Gainesville, Gainesville
AdventHealth Orlando, Orlando
Arnold Palmer Hospital for Children, Orlando
Nemours Children's Hospital, Orlando
Memorial Regional Hospital/Joe DiMaggio Children's Hospital, Hollywood
University of Miami Miller School of Medicine-Sylvester Cancer Center, Miami
Nicklaus Children's Hospital, Miami
Miami Cancer Institute, Miami
Broward Health Medical Center, Fort Lauderdale
Saint Mary's Medical Center, West Palm Beach
Palms West Radiation Therapy, Loxahatchee Groves
Tampa General Hospital, Tampa
Saint Joseph's Hospital/Children's Hospital-Tampa, Tampa
Johns Hopkins All Children's Hospital, St. Petersburg
Golisano Children's Hospital of Southwest Florida, Fort Myers
Children's Hospital of Alabama, Birmingham
USA Health Strada Patient Care Center, Mobile
The Children's Hospital at TriStar Centennial, Nashville
Vanderbilt University/Ingram Cancer Center, Nashville
T C Thompson Children's Hospital, Chattanooga
East Tennessee Childrens Hospital, Knoxville
University of Mississippi Medical Center, Jackson
Norton Children's Hospital, Louisville
University of Kentucky/Markey Cancer Center, Lexington
Nationwide Children's Hospital, Columbus
ProMedica Flower Hospital, Sylvania
ProMedica Toledo Hospital/Russell J Ebeid Children's Hospital, Toledo
Rainbow Babies and Childrens Hospital, Cleveland
Cleveland Clinic Foundation, Cleveland
Children's Hospital Medical Center of Akron, Akron
Cincinnati Children's Hospital Medical Center, Cincinnati
Dayton Children's Hospital, Dayton
Riley Hospital for Children, Indianapolis
Ascension Saint Vincent Indianapolis Hospital, Indianapolis
Huron Medical Center PC, Port Huron
Lake Huron Medical Center, Port Huron
Corewell Health Children's, Royal Oak
C S Mott Children's Hospital, Ann Arbor
University of Michigan Comprehensive Cancer Center, Ann Arbor
Wayne State University/Karmanos Cancer Institute, Detroit
Henry Ford Health Saint John Hospital, Detroit
Hurley Medical Center, Flint
Michigan State University, East Lansing
University of Michigan Health - Sparrow Lansing, Lansing
Bronson Methodist Hospital, Kalamazoo
West Michigan Cancer Center, Kalamazoo
Bronson Battle Creek, Battle Creek
Beacon Kalamazoo, Kalamazoo
Corewell Health Lakeland Hospitals - Marie Yeager Cancer Center, Saint Joseph
Corewell Health Lakeland Hospitals - Saint Joseph Hospital, Saint Joseph
Corewell Health Lakeland Hospitals - Niles Hospital, Niles
Trinity Health Muskegon Hospital, Muskegon
Corewell Health Grand Rapids Hospitals - Butterworth Hospital, Grand Rapids
Corewell Health Grand Rapids Hospitals - Helen DeVos Children's Hospital, Grand Rapids
Trinity Health Grand Rapids Hospital, Grand Rapids
University of Michigan Health - West, Wyoming
Corewell Health Reed City Hospital, Reed City
Munson Medical Center, Traverse City
Blank Children's Hospital, Des Moines
Iowa Methodist Medical Center, Des Moines
Iowa Lutheran Hospital, Des Moines
University of Iowa/Holden Comprehensive Cancer Center, Iowa City
Children's Hospital of Wisconsin, Milwaukee
University of Wisconsin Carbone Cancer Center - University Hospital, Madison
Marshfield Medical Center-Marshfield, Marshfield
Gundersen Lutheran Medical Center, La Crosse
Children's Hospitals and Clinics of Minnesota - Minneapolis, Minneapolis
University of Minnesota/Masonic Cancer Center, Minneapolis
Essentia Health Cancer Center, Duluth
Mayo Clinic in Rochester, Rochester
Sanford Broadway Medical Center, Fargo
Saint Patrick Hospital - Community Hospital, Missoula
Advocate Children's Hospital-Park Ridge, Park Ridge
Loyola University Medical Center, Maywood
Advocate Children's Hospital-Oak Lawn, Oak Lawn
Lurie Children's Hospital-Chicago, Chicago
John H Stroger Jr Hospital of Cook County, Chicago
Rush University Medical Center, Chicago
University of Illinois, Chicago
University of Chicago Comprehensive Cancer Center, Chicago
Saint Jude Midwest Affiliate, Peoria
Saint John's Hospital, Springfield
Southern Illinois University School of Medicine, Springfield
Springfield Memorial Hospital, Springfield
Cardinal Glennon Children's Medical Center, St Louis
Barnes-Jewish Hospital, St Louis
Washington University School of Medicine, St Louis
Siteman Cancer Center at West County Hospital, Creve Coeur
Mercy Hospital Saint Louis, St Louis
Siteman Cancer Center at Saint Peters Hospital, City of Saint Peters
Children's Mercy Hospitals and Clinics, Kansas City
University of Missouri Children's Hospital, Columbia
Children's Hospital and Medical Center of Omaha, Omaha
University of Nebraska Medical Center, Omaha
Children's Hospital New Orleans, New Orleans
Ochsner Medical Center Jefferson, New Orleans
University of Oklahoma Health Sciences Center, Oklahoma City
Medical City Dallas Hospital, Dallas
UT Southwestern/Simmons Cancer Center-Dallas, Dallas
Scott and White Memorial Hospital, Temple
Baylor College of Medicine/Dan L Duncan Comprehensive Cancer Center, Houston
M D Anderson Cancer Center, Houston
Children's Hospital of San Antonio, San Antonio
Cancer Therapy and Research Center at The UT Health Science Center at San Antonio, San Antonio
Methodist Children's Hospital of South Texas, San Antonio
University Hospital, San Antonio
University of Texas Health Science Center at San Antonio, San Antonio
Driscoll Children's Hospital, Corpus Christi
Dell Children's Medical Center of Central Texas, Austin
Texas Tech University Health Sciences Center-Amarillo, Amarillo
Covenant Children's Hospital, Lubbock
UMC Cancer Center / UMC Health System, Lubbock
Texas Tech University Health Sciences Center-Lubbock, Lubbock
El Paso Children's Hospital, El Paso
Children's Hospital Colorado, Aurora
Rocky Mountain Hospital for Children-Presbyterian Saint Luke's Medical Center, Denver
Saint Luke's Cancer Institute - Twin Falls, Twin Falls
Saint Luke's Cancer Institute - Fruitland, Fruitland
Saint Luke's Cancer Institute - Meridian, Meridian
Saint Luke's Cancer Institute - Nampa, Nampa
Saint Luke's Cancer Institute - Boise, Boise
Primary Children's Hospital, Salt Lake City
Phoenix Childrens Hospital, Phoenix
Mayo Clinic Hospital in Arizona, Phoenix
Banner Children's at Desert, Mesa
Mayo Clinic in Arizona, Scottsdale
Banner University Medical Center - Tucson, Tucson
Kingman Regional Medical Center, Kingman
Presbyterian Hospital, Albuquerque
Hope Cancer Care of Nevada-Pahrump, Pahrump
Cancer and Blood Specialists-Henderson, Henderson
Comprehensive Cancer Centers of Nevada - Henderson, Henderson
Comprehensive Cancer Centers of Nevada-Horizon Ridge, Henderson
Las Vegas Cancer Center-Henderson, Henderson
OptumCare Cancer Care at Seven Hills, Henderson
Comprehensive Cancer Centers of Nevada-Southeast Henderson, Henderson
Las Vegas Urology - Green Valley, Henderson
Las Vegas Urology - Pebble, Henderson
Oncology Las Vegas - Henderson, Henderson
Urology Specialists of Nevada - Green Valley, Henderson
Las Vegas Urology - Pecos, Las Vegas
Desert West Surgery, Las Vegas
OptumCare Cancer Care at Charleston, Las Vegas
University Medical Center of Southern Nevada, Las Vegas
Cancer and Blood Specialists-Shadow, Las Vegas
Radiation Oncology Centers of Nevada Central, Las Vegas
Urology Specialists of Nevada - Central, Las Vegas
GenesisCare USA - Las Vegas, Las Vegas
HealthCare Partners Medical Group Oncology/Hematology-Maryland Parkway, Las Vegas
Sunrise Hospital and Medical Center, Las Vegas
HealthCare Partners Medical Group Oncology/Hematology-San Martin, Las Vegas
Las Vegas Urology - Sunset, Las Vegas
Urology Specialists of Nevada - Southwest, Las Vegas
Radiation Oncology Centers of Nevada Southeast, Las Vegas
Cancer Therapy and Integrative Medicine, Las Vegas
Ann M Wierman MD LTD, Las Vegas
Cancer and Blood Specialists-Tenaya, Las Vegas
Comprehensive Cancer Centers of Nevada - Northwest, Las Vegas
HealthCare Partners Medical Group Oncology/Hematology-Tenaya, Las Vegas
Las Vegas Urology - Cathedral Rock, Las Vegas
Las Vegas Urology - Smoke Ranch, Las Vegas
Oncology Las Vegas - Tenaya, Las Vegas
OptumCare Cancer Care at MountainView, Las Vegas
Urology Specialists of Nevada - Northwest, Las Vegas
Alliance for Childhood Diseases/Cure 4 the Kids Foundation, Las Vegas
Comprehensive Cancer Centers of Nevada - Town Center, Las Vegas
Comprehensive Cancer Centers of Nevada-Summerlin, Las Vegas
Summerlin Hospital Medical Center, Las Vegas
Comprehensive Cancer Centers of Nevada, Las Vegas
GenesisCare USA - Fort Apache, Las Vegas
OptumCare Cancer Care at Fort Apache, Las Vegas
HealthCare Partners Medical Group Oncology/Hematology-Centennial Hills, Las Vegas
Comprehensive Cancer Centers of Nevada - Central Valley, Las Vegas
University Cancer Center, Las Vegas
Renown Regional Medical Center, Reno
Saint Mary's Regional Medical Center, Reno
Radiation Oncology Associates, Reno
Carson Tahoe Regional Medical Center, Carson City
Children's Hospital Los Angeles, Los Angeles
Kaiser Permanente Los Angeles Medical Center, Los Angeles
Mattel Children's Hospital UCLA, Los Angeles
UCLA / Jonsson Comprehensive Cancer Center, Los Angeles
Kaiser Permanente Downey Medical Center, Downey
Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance
Kaiser Permanente-Bellflower, Bellflower
Providence Saint Joseph Medical Center/Disney Family Cancer Center, Burbank
Kaiser Permanente-San Diego Mission, San Diego
Rady Children's Hospital - San Diego, San Diego
Naval Medical Center -San Diego, San Diego
Kaiser Permanente-Fontana, Fontana
Loma Linda University Medical Center, Loma Linda
Kaiser Permanente-Anaheim, Anaheim
Children's Hospital of Orange County, Orange
PCR Oncology, Arroyo Grande
Valley Children's Hospital, Madera
UCSF Medical Center-Mission Bay, San Francisco
Lucile Packard Children's Hospital Stanford University, Palo Alto
UCSF Benioff Children's Hospital Oakland, Oakland
Kaiser Permanente-Oakland, Oakland
Kaiser Permanente Medical Center - Santa Clara, Santa Clara
Kaiser Permanente-Roseville, Roseville
Sutter Medical Center Sacramento, Sacramento
University of California Davis Comprehensive Cancer Center, Sacramento
Straub Clinic and Hospital, Honolulu
Kaiser Permanente Moanalua Medical Center, Honolulu
Kapiolani Medical Center for Women and Children, Honolulu
Clackamas Radiation Oncology Center, Clackamas
Providence Cancer Institute Clackamas Clinic, Clackamas
Providence Newberg Medical Center, Newberg
Providence Portland Medical Center, Portland
Providence Saint Vincent Medical Center, Portland
Legacy Emanuel Children's Hospital, Portland
Oregon Health and Science University, Portland
Bay Area Hospital, Coos Bay
Saint Charles Health System, Bend
Overlake Medical Center, Bellevue
Swedish Cancer Institute-Edmonds, Edmonds
Swedish Cancer Institute-Issaquah, Issaquah
Pacific Gynecology Specialists, Seattle
Seattle Children's Hospital, Seattle
Swedish Medical Center-Ballard Campus, Seattle
Kaiser Permanente Washington, Seattle
Swedish Medical Center-First Hill, Seattle
University of Washington Medical Center - Montlake, Seattle
Providence Regional Cancer Partnership, Everett
PeaceHealth Saint Joseph Medical Center, Bellingham
Mary Bridge Children's Hospital and Health Center, Tacoma
Madigan Army Medical Center, Tacoma
Providence Regional Cancer System-Lacey, Lacey
Anchorage Associates in Radiation Medicine, Anchorage
Providence Regional Cancer System-Aberdeen, Aberdeen
Providence Regional Cancer System-Centralia, Centralia
Providence Regional Cancer System-Shelton, Shelton
Providence Regional Cancer System-Yelm, Yelm
PeaceHealth Saint John Medical Center, Longview
PeaceHealth Southwest Medical Center, Vancouver
North Star Lodge Cancer Center at Yakima Valley Memorial Hospital, Yakima
MultiCare Deaconess Cancer and Blood Specialty Center - Downtown, Spokane
Providence Sacred Heart Medical Center and Children's Hospital, Spokane
MultiCare Deaconess Cancer and Blood Specialty Center - Valley, Spokane Valley
MultiCare Deaconess Cancer and Blood Specialty Center - North, Spokane
Kadlec Clinic Hematology and Oncology, Kennewick
Providence Saint Mary Regional Cancer Center, Walla Walla
Anchorage Radiation Therapy Center, Anchorage
Alaska Breast Care and Surgery LLC, Anchorage
Alaska Oncology and Hematology LLC, Anchorage
Alaska Women's Cancer Care, Anchorage
Anchorage Oncology Centre, Anchorage
Katmai Oncology Group, Anchorage
Providence Alaska Medical Center, Anchorage
Arkansas Children's Hospital, Little Rock
Connecticut Children's Medical Center, Hartford
Smilow Cancer Center/Yale-New Haven Hospital, New Haven
Yale University, New Haven
Smilow Cancer Hospital Care Center-Trumbull, Trumbull
Eastern Maine Medical Center, Bangor
Maine Children's Cancer Program, Scarborough
Walter Reed National Military Medical Center, Bethesda
Tufts Children's Hospital, Boston
Massachusetts General Hospital Cancer Center, Boston
Dana-Farber Cancer Institute, Boston
UMass Memorial Medical Center - University Campus, Worcester
Las Vegas Cancer Center-Medical Center, Las Vegas
Dartmouth Hitchcock Medical Center/Dartmouth Cancer Center, Lebanon
Hackensack University Medical Center, Hackensack
Morristown Medical Center, Morristown
Saint Peter's University Hospital, New Brunswick
Rutgers Cancer Institute of New Jersey-Robert Wood Johnson University Hospital, New Brunswick
Rutgers Cancer Institute of New Jersey, New Brunswick
Newark Beth Israel Medical Center, Newark
Saint Joseph's Regional Medical Center, Paterson
Rhode Island Hospital, Providence
Sanford USD Medical Center - Sioux Falls, Sioux Falls
Central Vermont Medical Center/National Life Cancer Treatment, Berlin Corners
University of Vermont Medical Center, Burlington
University of Vermont and State Agricultural College, Burlington
Naval Medical Center - Portsmouth, Portsmouth
Swedish Medical Center-Cherry Hill, Seattle
Alberta Children's Hospital, Calgary
University of Alberta Hospital, Edmonton
British Columbia Children's Hospital, Vancouver
CancerCare Manitoba, Winnipeg
Janeway Child Health Centre, St. John's
IWK Health Centre, Halifax
McMaster Children's Hospital at Hamilton Health Sciences, Hamilton
Kingston Health Sciences Centre, Kingston
Children's Hospital, London
Children's Hospital of Eastern Ontario, Ottawa
Hospital for Sick Children, Toronto
The Montreal Children's Hospital of the MUHC, Montreal
Centre Hospitalier Universitaire Sainte-Justine, Montreal
Jim Pattison Children's Hospital, Saskatoon
Saskatoon Cancer Centre, Saskatoon
CHU de Quebec-Centre Hospitalier de l'Universite Laval (CHUL), Québec
HIMA San Pablo Oncologic Hospital, Caguas
San Jorge Children's Hospital, San Juan
University Pediatric Hospital, San Juan
National Cancer Institute (NCI)
NIH