Combination Chemotherapy With or Without Temsirolimus in Treating Patients With Intermediate Risk Rhabdomyosarcoma

PHASE3Active, not recruitingINTERVENTIONAL
Enrollment

325

Participants

Timeline

Start Date

June 1, 2016

Primary Completion Date

June 30, 2023

Study Completion Date

October 16, 2025

Conditions
Alveolar RhabdomyosarcomaBotryoid-Type Embryonal RhabdomyosarcomaEmbryonal RhabdomyosarcomaRhabdomyosarcomaSclerosing RhabdomyosarcomaSpindle Cell Rhabdomyosarcoma
Interventions
DRUG

Cyclophosphamide

Given IV and PO

BIOLOGICAL

Dactinomycin

Given IV

DRUG

Irinotecan Hydrochloride

Given IV

OTHER

Laboratory Biomarker Analysis

Correlative studies

OTHER

Questionnaire Administration

Ancillary studies

RADIATION

Radiation Therapy

Undergo RT

DRUG

Temsirolimus

Given IV

DRUG

Vincristine Sulfate

Given IV

DRUG

Vinorelbine

Given IV

Trial Locations (386)

1145

Starship Children's Hospital, Grafton

2031

Sydney Children's Hospital, Randwick

2145

The Children's Hospital at Westmead, Westmead

2310

John Hunter Children's Hospital, Hunter Regional Mail Centre

4101

Queensland Children's Hospital, South Brisbane

6008

Princess Margaret Hospital for Children, Perth

6009

Perth Children's Hospital, Perth

8011

Christchurch Hospital, Christchurch

10016

Laura and Isaac Perlmutter Cancer Center at NYU Langone, New York

10029

Mount Sinai Hospital, New York

10032

NYP/Columbia University Medical Center/Herbert Irving Comprehensive Cancer Center, New York

10065

Memorial Sloan Kettering Cancer Center, New York

10461

Montefiore Medical Center-Einstein Campus, The Bronx

Montefiore Medical Center-Weiler Hospital, The Bronx

10467

Children's Hospital at Montefiore, The Bronx

Montefiore Medical Center - Moses Campus, The Bronx

10595

New York Medical College, Valhalla

Westchester Medical Center, Valhalla

11040

The Steven and Alexandra Cohen Children's Medical Center of New York, New Hyde Park

11219

Maimonides Medical Center, Brooklyn

11501

NYU Langone Hospital - Long Island, Mineola

11794

Stony Brook University Medical Center, Stony Brook

12208

Albany Medical Center, Albany

12801

Glens Falls Hospital, Glens Falls

13210

State University of New York Upstate Medical University, Syracuse

14263

Roswell Park Cancer Institute, Buffalo

14642

University of Rochester, Rochester

15224

Children's Hospital of Pittsburgh of UPMC, Pittsburgh

17033

Penn State Children's Hospital, Hershey

17822

Geisinger Medical Center, Danville

18017

Lehigh Valley Hospital - Muhlenberg, Bethlehem

18103

Lehigh Valley Hospital-Cedar Crest, Allentown

19104

Children's Hospital of Philadelphia, Philadelphia

19134

Saint Christopher's Hospital for Children, Philadelphia

19803

Alfred I duPont Hospital for Children, Wilmington

20002

Kaiser Permanente-Capitol Hill Medical Center, Washington D.C.

20007

MedStar Georgetown University Hospital, Washington D.C.

20010

Children's National Medical Center, Washington D.C.

20016

Sibley Memorial Hospital, Washington D.C.

21201

University of Maryland/Greenebaum Cancer Center, Baltimore

21215

Sinai Hospital of Baltimore, Baltimore

21287

Johns Hopkins University/Sidney Kimmel Cancer Center, Baltimore

22042

Inova Fairfax Hospital, Falls Church

22908

University of Virginia Cancer Center, Charlottesville

23298

VCU Massey Comprehensive Cancer Center, Richmond

23507

Children's Hospital of The King's Daughters, Norfolk

25304

West Virginia University Charleston Division, Charleston

25401

WVUH-Berkely Medical Center, Martinsburg

26101

Camden Clark Medical Center, Parkersburg

26330

United Hospital Center, Bridgeport

26506

West Virginia University Healthcare, Morgantown

27157

Wake Forest University Health Sciences, Winston-Salem

27599

UNC Lineberger Comprehensive Cancer Center, Chapel Hill

27710

Duke University Medical Center, Durham

27834

East Carolina University, Greenville

28078

Novant Health Cancer Institute - Huntersville, Huntersville

Novant Health Presbyterian Medical Center Huntersville, Huntersville

Southern Oncology Specialists-Huntersville, Huntersville

28105

Matthews Radiation Oncology Center, Matthews

Novant Health Cancer Institute - Matthews, Matthews

28117

Novant Health Cancer Institute - Mooresville, Mooresville

28144

Novant Health Cancer Institute - Rowan, Salisbury

Rowan Regional Medical Center, Salisbury

28203

Carolinas Medical Center/Levine Cancer Institute, Charlotte

28204

Novant Health Presbyterian Medical Center, Charlotte

28207

Novant Health Carolina Surgical - Randolph, Charlotte

Oncology Specialists of Charlotte, Charlotte

28262

Southern Oncology Specialists-Charlotte, Charlotte

28801

Mission Hospital, Asheville

29203

Prisma Health Richland Hospital, Columbia

29316

Prisma Health Cancer Institute - Spartanburg, Boiling Springs

29325

Prisma Health Cancer Institute - Laurens, Clinton

29425

Medical University of South Carolina, Charleston

29601

Saint Francis Hospital, Greenville

29605

BI-LO Charities Children's Cancer Center, Greenville

Prisma Health Cancer Institute - Butternut, Greenville

Prisma Health Cancer Institute - Faris, Greenville

29607

Saint Francis Cancer Center, Greenville

29615

Prisma Health Cancer Institute - Eastside, Greenville

29640

Prisma Health Cancer Institute - Easley, Easley

29650

Prisma Health Cancer Institute - Greer, Greer

29672

Prisma Health Cancer Institute - Seneca, Seneca

30329

Children's Healthcare of Atlanta - Arthur M Blank Hospital, Atlanta

30912

Augusta University Medical Center, Augusta

31201

Atrium Health Navicent, Macon

31404

Memorial Health University Medical Center, Savannah

32207

Nemours Children's Clinic-Jacksonville, Jacksonville

32504

Nemours Children's Clinic - Pensacola, Pensacola

Sacred Heart Hospital, Pensacola

32610

University of Florida Health Science Center - Gainesville, Gainesville

32803

AdventHealth Orlando, Orlando

32806

Arnold Palmer Hospital for Children, Orlando

32827

Nemours Children's Hospital, Orlando

33021

Memorial Regional Hospital/Joe DiMaggio Children's Hospital, Hollywood

33136

University of Miami Miller School of Medicine-Sylvester Cancer Center, Miami

33155

Nicklaus Children's Hospital, Miami

33176

Miami Cancer Institute, Miami

33316

Broward Health Medical Center, Fort Lauderdale

33407

Saint Mary's Medical Center, West Palm Beach

33470

Palms West Radiation Therapy, Loxahatchee Groves

33606

Tampa General Hospital, Tampa

33607

Saint Joseph's Hospital/Children's Hospital-Tampa, Tampa

33701

Johns Hopkins All Children's Hospital, St. Petersburg

33908

Golisano Children's Hospital of Southwest Florida, Fort Myers

35233

Children's Hospital of Alabama, Birmingham

36604

USA Health Strada Patient Care Center, Mobile

37203

The Children's Hospital at TriStar Centennial, Nashville

37232

Vanderbilt University/Ingram Cancer Center, Nashville

37403

T C Thompson Children's Hospital, Chattanooga

37916

East Tennessee Childrens Hospital, Knoxville

39216

University of Mississippi Medical Center, Jackson

40202

Norton Children's Hospital, Louisville

40536

University of Kentucky/Markey Cancer Center, Lexington

43205

Nationwide Children's Hospital, Columbus

43560

ProMedica Flower Hospital, Sylvania

43606

ProMedica Toledo Hospital/Russell J Ebeid Children's Hospital, Toledo

44106

Rainbow Babies and Childrens Hospital, Cleveland

44195

Cleveland Clinic Foundation, Cleveland

44308

Children's Hospital Medical Center of Akron, Akron

45229

Cincinnati Children's Hospital Medical Center, Cincinnati

45404

Dayton Children's Hospital, Dayton

46202

Riley Hospital for Children, Indianapolis

46260

Ascension Saint Vincent Indianapolis Hospital, Indianapolis

48060

Huron Medical Center PC, Port Huron

Lake Huron Medical Center, Port Huron

48073

Corewell Health Children's, Royal Oak

48109

C S Mott Children's Hospital, Ann Arbor

University of Michigan Comprehensive Cancer Center, Ann Arbor

48201

Wayne State University/Karmanos Cancer Institute, Detroit

48236

Henry Ford Health Saint John Hospital, Detroit

48503

Hurley Medical Center, Flint

48823

Michigan State University, East Lansing

48912

University of Michigan Health - Sparrow Lansing, Lansing

49007

Bronson Methodist Hospital, Kalamazoo

West Michigan Cancer Center, Kalamazoo

49017

Bronson Battle Creek, Battle Creek

49048

Beacon Kalamazoo, Kalamazoo

49085

Corewell Health Lakeland Hospitals - Marie Yeager Cancer Center, Saint Joseph

Corewell Health Lakeland Hospitals - Saint Joseph Hospital, Saint Joseph

49120

Corewell Health Lakeland Hospitals - Niles Hospital, Niles

49444

Trinity Health Muskegon Hospital, Muskegon

49503

Corewell Health Grand Rapids Hospitals - Butterworth Hospital, Grand Rapids

Corewell Health Grand Rapids Hospitals - Helen DeVos Children's Hospital, Grand Rapids

Trinity Health Grand Rapids Hospital, Grand Rapids

49519

University of Michigan Health - West, Wyoming

49677

Corewell Health Reed City Hospital, Reed City

49684

Munson Medical Center, Traverse City

50309

Blank Children's Hospital, Des Moines

Iowa Methodist Medical Center, Des Moines

50316

Iowa Lutheran Hospital, Des Moines

52242

University of Iowa/Holden Comprehensive Cancer Center, Iowa City

53226

Children's Hospital of Wisconsin, Milwaukee

53792

University of Wisconsin Carbone Cancer Center - University Hospital, Madison

54449

Marshfield Medical Center-Marshfield, Marshfield

54601

Gundersen Lutheran Medical Center, La Crosse

55404

Children's Hospitals and Clinics of Minnesota - Minneapolis, Minneapolis

55455

University of Minnesota/Masonic Cancer Center, Minneapolis

55805

Essentia Health Cancer Center, Duluth

55905

Mayo Clinic in Rochester, Rochester

58122

Sanford Broadway Medical Center, Fargo

59802

Saint Patrick Hospital - Community Hospital, Missoula

60068

Advocate Children's Hospital-Park Ridge, Park Ridge

60153

Loyola University Medical Center, Maywood

60453

Advocate Children's Hospital-Oak Lawn, Oak Lawn

60611

Lurie Children's Hospital-Chicago, Chicago

60612

John H Stroger Jr Hospital of Cook County, Chicago

Rush University Medical Center, Chicago

University of Illinois, Chicago

60637

University of Chicago Comprehensive Cancer Center, Chicago

61637

Saint Jude Midwest Affiliate, Peoria

62702

Saint John's Hospital, Springfield

Southern Illinois University School of Medicine, Springfield

62781

Springfield Memorial Hospital, Springfield

63104

Cardinal Glennon Children's Medical Center, St Louis

63110

Barnes-Jewish Hospital, St Louis

Washington University School of Medicine, St Louis

63141

Siteman Cancer Center at West County Hospital, Creve Coeur

Mercy Hospital Saint Louis, St Louis

63376

Siteman Cancer Center at Saint Peters Hospital, City of Saint Peters

64108

Children's Mercy Hospitals and Clinics, Kansas City

65212

University of Missouri Children's Hospital, Columbia

68114

Children's Hospital and Medical Center of Omaha, Omaha

68198

University of Nebraska Medical Center, Omaha

70118

Children's Hospital New Orleans, New Orleans

70121

Ochsner Medical Center Jefferson, New Orleans

73104

University of Oklahoma Health Sciences Center, Oklahoma City

75230

Medical City Dallas Hospital, Dallas

75390

UT Southwestern/Simmons Cancer Center-Dallas, Dallas

76508

Scott and White Memorial Hospital, Temple

77030

Baylor College of Medicine/Dan L Duncan Comprehensive Cancer Center, Houston

M D Anderson Cancer Center, Houston

78207

Children's Hospital of San Antonio, San Antonio

78229

Cancer Therapy and Research Center at The UT Health Science Center at San Antonio, San Antonio

Methodist Children's Hospital of South Texas, San Antonio

University Hospital, San Antonio

University of Texas Health Science Center at San Antonio, San Antonio

78411

Driscoll Children's Hospital, Corpus Christi

78723

Dell Children's Medical Center of Central Texas, Austin

79106

Texas Tech University Health Sciences Center-Amarillo, Amarillo

79410

Covenant Children's Hospital, Lubbock

79415

UMC Cancer Center / UMC Health System, Lubbock

79430

Texas Tech University Health Sciences Center-Lubbock, Lubbock

79905

El Paso Children's Hospital, El Paso

80045

Children's Hospital Colorado, Aurora

80218

Rocky Mountain Hospital for Children-Presbyterian Saint Luke's Medical Center, Denver

83301

Saint Luke's Cancer Institute - Twin Falls, Twin Falls

83619

Saint Luke's Cancer Institute - Fruitland, Fruitland

83642

Saint Luke's Cancer Institute - Meridian, Meridian

83687

Saint Luke's Cancer Institute - Nampa, Nampa

83712

Saint Luke's Cancer Institute - Boise, Boise

84113

Primary Children's Hospital, Salt Lake City

85016

Phoenix Childrens Hospital, Phoenix

85054

Mayo Clinic Hospital in Arizona, Phoenix

85202

Banner Children's at Desert, Mesa

85259

Mayo Clinic in Arizona, Scottsdale

85719

Banner University Medical Center - Tucson, Tucson

86401

Kingman Regional Medical Center, Kingman

87106

Presbyterian Hospital, Albuquerque

89048

Hope Cancer Care of Nevada-Pahrump, Pahrump

89052

Cancer and Blood Specialists-Henderson, Henderson

Comprehensive Cancer Centers of Nevada - Henderson, Henderson

Comprehensive Cancer Centers of Nevada-Horizon Ridge, Henderson

Las Vegas Cancer Center-Henderson, Henderson

OptumCare Cancer Care at Seven Hills, Henderson

89074

Comprehensive Cancer Centers of Nevada-Southeast Henderson, Henderson

Las Vegas Urology - Green Valley, Henderson

Las Vegas Urology - Pebble, Henderson

Oncology Las Vegas - Henderson, Henderson

Urology Specialists of Nevada - Green Valley, Henderson

Las Vegas Urology - Pecos, Las Vegas

89102

Desert West Surgery, Las Vegas

OptumCare Cancer Care at Charleston, Las Vegas

University Medical Center of Southern Nevada, Las Vegas

89106

Cancer and Blood Specialists-Shadow, Las Vegas

Radiation Oncology Centers of Nevada Central, Las Vegas

Urology Specialists of Nevada - Central, Las Vegas

89109

GenesisCare USA - Las Vegas, Las Vegas

HealthCare Partners Medical Group Oncology/Hematology-Maryland Parkway, Las Vegas

Sunrise Hospital and Medical Center, Las Vegas

89113

HealthCare Partners Medical Group Oncology/Hematology-San Martin, Las Vegas

Las Vegas Urology - Sunset, Las Vegas

Urology Specialists of Nevada - Southwest, Las Vegas

89119

Radiation Oncology Centers of Nevada Southeast, Las Vegas

89121

Cancer Therapy and Integrative Medicine, Las Vegas

89128

Ann M Wierman MD LTD, Las Vegas

Cancer and Blood Specialists-Tenaya, Las Vegas

Comprehensive Cancer Centers of Nevada - Northwest, Las Vegas

HealthCare Partners Medical Group Oncology/Hematology-Tenaya, Las Vegas

Las Vegas Urology - Cathedral Rock, Las Vegas

Las Vegas Urology - Smoke Ranch, Las Vegas

Oncology Las Vegas - Tenaya, Las Vegas

OptumCare Cancer Care at MountainView, Las Vegas

Urology Specialists of Nevada - Northwest, Las Vegas

89135

Alliance for Childhood Diseases/Cure 4 the Kids Foundation, Las Vegas

89144

Comprehensive Cancer Centers of Nevada - Town Center, Las Vegas

Comprehensive Cancer Centers of Nevada-Summerlin, Las Vegas

Summerlin Hospital Medical Center, Las Vegas

89148

Comprehensive Cancer Centers of Nevada, Las Vegas

GenesisCare USA - Fort Apache, Las Vegas

OptumCare Cancer Care at Fort Apache, Las Vegas

89149

HealthCare Partners Medical Group Oncology/Hematology-Centennial Hills, Las Vegas

89169

Comprehensive Cancer Centers of Nevada - Central Valley, Las Vegas

University Cancer Center, Las Vegas

89502

Renown Regional Medical Center, Reno

89503

Saint Mary's Regional Medical Center, Reno

89509

Radiation Oncology Associates, Reno

89703

Carson Tahoe Regional Medical Center, Carson City

90027

Children's Hospital Los Angeles, Los Angeles

Kaiser Permanente Los Angeles Medical Center, Los Angeles

90095

Mattel Children's Hospital UCLA, Los Angeles

UCLA / Jonsson Comprehensive Cancer Center, Los Angeles

90242

Kaiser Permanente Downey Medical Center, Downey

90502

Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance

90706

Kaiser Permanente-Bellflower, Bellflower

91505

Providence Saint Joseph Medical Center/Disney Family Cancer Center, Burbank

92108

Kaiser Permanente-San Diego Mission, San Diego

92123

Rady Children's Hospital - San Diego, San Diego

92134

Naval Medical Center -San Diego, San Diego

92335

Kaiser Permanente-Fontana, Fontana

92354

Loma Linda University Medical Center, Loma Linda

92806

Kaiser Permanente-Anaheim, Anaheim

92868

Children's Hospital of Orange County, Orange

93420

PCR Oncology, Arroyo Grande

93636

Valley Children's Hospital, Madera

94158

UCSF Medical Center-Mission Bay, San Francisco

94304

Lucile Packard Children's Hospital Stanford University, Palo Alto

94609

UCSF Benioff Children's Hospital Oakland, Oakland

94611

Kaiser Permanente-Oakland, Oakland

95051

Kaiser Permanente Medical Center - Santa Clara, Santa Clara

95661

Kaiser Permanente-Roseville, Roseville

95816

Sutter Medical Center Sacramento, Sacramento

95817

University of California Davis Comprehensive Cancer Center, Sacramento

96813

Straub Clinic and Hospital, Honolulu

96819

Kaiser Permanente Moanalua Medical Center, Honolulu

96826

Kapiolani Medical Center for Women and Children, Honolulu

97015

Clackamas Radiation Oncology Center, Clackamas

Providence Cancer Institute Clackamas Clinic, Clackamas

97132

Providence Newberg Medical Center, Newberg

97213

Providence Portland Medical Center, Portland

97225

Providence Saint Vincent Medical Center, Portland

97227

Legacy Emanuel Children's Hospital, Portland

97239

Oregon Health and Science University, Portland

97420

Bay Area Hospital, Coos Bay

97701

Saint Charles Health System, Bend

98004

Overlake Medical Center, Bellevue

98026

Swedish Cancer Institute-Edmonds, Edmonds

98029

Swedish Cancer Institute-Issaquah, Issaquah

98104

Pacific Gynecology Specialists, Seattle

98105

Seattle Children's Hospital, Seattle

98107

Swedish Medical Center-Ballard Campus, Seattle

98112

Kaiser Permanente Washington, Seattle

98122

Swedish Medical Center-First Hill, Seattle

98195

University of Washington Medical Center - Montlake, Seattle

98201

Providence Regional Cancer Partnership, Everett

98225

PeaceHealth Saint Joseph Medical Center, Bellingham

98405

Mary Bridge Children's Hospital and Health Center, Tacoma

98431

Madigan Army Medical Center, Tacoma

98503

Providence Regional Cancer System-Lacey, Lacey

98508

Anchorage Associates in Radiation Medicine, Anchorage

98520

Providence Regional Cancer System-Aberdeen, Aberdeen

98531

Providence Regional Cancer System-Centralia, Centralia

98584

Providence Regional Cancer System-Shelton, Shelton

98597

Providence Regional Cancer System-Yelm, Yelm

98632

PeaceHealth Saint John Medical Center, Longview

98664

PeaceHealth Southwest Medical Center, Vancouver

98902

North Star Lodge Cancer Center at Yakima Valley Memorial Hospital, Yakima

99204

MultiCare Deaconess Cancer and Blood Specialty Center - Downtown, Spokane

Providence Sacred Heart Medical Center and Children's Hospital, Spokane

99216

MultiCare Deaconess Cancer and Blood Specialty Center - Valley, Spokane Valley

99218

MultiCare Deaconess Cancer and Blood Specialty Center - North, Spokane

99336

Kadlec Clinic Hematology and Oncology, Kennewick

99362

Providence Saint Mary Regional Cancer Center, Walla Walla

99504

Anchorage Radiation Therapy Center, Anchorage

99508

Alaska Breast Care and Surgery LLC, Anchorage

Alaska Oncology and Hematology LLC, Anchorage

Alaska Women's Cancer Care, Anchorage

Anchorage Oncology Centre, Anchorage

Katmai Oncology Group, Anchorage

Providence Alaska Medical Center, Anchorage

72202-3591

Arkansas Children's Hospital, Little Rock

06106

Connecticut Children's Medical Center, Hartford

06510

Smilow Cancer Center/Yale-New Haven Hospital, New Haven

06520

Yale University, New Haven

06611

Smilow Cancer Hospital Care Center-Trumbull, Trumbull

04401

Eastern Maine Medical Center, Bangor

04074

Maine Children's Cancer Program, Scarborough

20889-5600

Walter Reed National Military Medical Center, Bethesda

02111

Tufts Children's Hospital, Boston

02114

Massachusetts General Hospital Cancer Center, Boston

02215

Dana-Farber Cancer Institute, Boston

01655

UMass Memorial Medical Center - University Campus, Worcester

89148-2405

Las Vegas Cancer Center-Medical Center, Las Vegas

03756

Dartmouth Hitchcock Medical Center/Dartmouth Cancer Center, Lebanon

07601

Hackensack University Medical Center, Hackensack

07960

Morristown Medical Center, Morristown

08901

Saint Peter's University Hospital, New Brunswick

08903

Rutgers Cancer Institute of New Jersey-Robert Wood Johnson University Hospital, New Brunswick

Rutgers Cancer Institute of New Jersey, New Brunswick

07112

Newark Beth Israel Medical Center, Newark

07503

Saint Joseph's Regional Medical Center, Paterson

02903

Rhode Island Hospital, Providence

57117-5134

Sanford USD Medical Center - Sioux Falls, Sioux Falls

05602

Central Vermont Medical Center/National Life Cancer Treatment, Berlin Corners

05401

University of Vermont Medical Center, Burlington

05405

University of Vermont and State Agricultural College, Burlington

23708-2197

Naval Medical Center - Portsmouth, Portsmouth

98122-5711

Swedish Medical Center-Cherry Hill, Seattle

T3B 6A8

Alberta Children's Hospital, Calgary

T6G 2B7

University of Alberta Hospital, Edmonton

V6H 3V4

British Columbia Children's Hospital, Vancouver

R3E 0V9

CancerCare Manitoba, Winnipeg

A1B 3V6

Janeway Child Health Centre, St. John's

B3K 6R8

IWK Health Centre, Halifax

L8N 3Z5

McMaster Children's Hospital at Hamilton Health Sciences, Hamilton

K7L 2V7

Kingston Health Sciences Centre, Kingston

N6A 5W9

Children's Hospital, London

K1H 8L1

Children's Hospital of Eastern Ontario, Ottawa

M5G 1X8

Hospital for Sick Children, Toronto

H3H 1P3

The Montreal Children's Hospital of the MUHC, Montreal

H3T 1C5

Centre Hospitalier Universitaire Sainte-Justine, Montreal

S7N 0W8

Jim Pattison Children's Hospital, Saskatoon

S7N 4H4

Saskatoon Cancer Centre, Saskatoon

G1V 4G2

CHU de Quebec-Centre Hospitalier de l'Universite Laval (CHUL), Québec

00726

HIMA San Pablo Oncologic Hospital, Caguas

00912

San Jorge Children's Hospital, San Juan

00926

University Pediatric Hospital, San Juan

All Listed Sponsors
lead

National Cancer Institute (NCI)

NIH