A Study to Evaluate the Safety and Efficacy of Long Term Treatment With VX-661 in Combination With Ivacaftor in Participants With Cystic Fibrosis Who Have an F508del-CFTR Mutation

PHASE3CompletedINTERVENTIONAL
Enrollment

1,131

Participants

Timeline

Start Date

August 31, 2015

Primary Completion Date

May 31, 2019

Study Completion Date

December 5, 2022

Conditions
Cystic Fibrosis
Interventions
DRUG

TEZ/IVA

Fixed dose tablet for oral administration.

DRUG

IVA

Tablet for oral administration.

Trial Locations (154)

Unknown

Birmingham

Tucson

Little Rock

Long Beach

Los Angeles

Oakland

Palo Alto

Sacramento

San Diego

Aurora

Denver

Gainesville

Miami

Orlando

Pensacola

Tampa

Atlanta

Boise

Chicago

Glenview

Niles

Peoria

Indianapolis

Iowa City

Lexington

New Orleans

Baltimore

Boston

Ann Arbor

Detroit

Minneapolis

Kansas City

St Louis

Omaha

Lebanon

Long Branch

New Brunswick

Albuquerque

Albany

Buffalo

New Hyde Park

New York

Rochester

Syracuse

Chapel Hill

Akron

Cincinnati

Cleveland

Columbus

Toledo

Oklahoma City

Portland

Philadelphia

Pittsburgh

Charleston

Sioux Falls

Knoxville

Memphis

Nashville

Austin

Dallas

Fort Worth

Houston

Tyler

Salt Lake City

Seattle

Spokane

Morgantown

Milwaukee

Chermside

Melbourne

South Brisbane

Westmead

Graz

Innsbruck

Salzburg

Brussels

Ghent

Leuven

Vancouver

Toronto

Halifax

Montreal

Québec

Copenhagen

Benite Cedex

Bordeaux

Bron

Lille

Marseille

Montpellier

Paris

Rennes

Roscoff

Rouen

Berlin

Bochum

Erlangen

Essen

Frankfurt

Giesen

Hannover

Heidelberg

Jena

München

Tübingen

Würzburg

Cork

Dublin

Limerick

Haifa

Haifa

Jerusalem

Petah Tikva

Tel Litwinsky

Ancona

Genova

Milan

Orbassano

Palermo

Potenza

Roma

Rome

Torino

Verona

Amsterdam

Heidelberglaan

Nijmegen

Rotterdam

The Hague

Barcelona

Madrid

Sabadell

Seville

Valencia

Gothenburg

Stockholm

Uppsala

Bern

Zurich

Leeds

Belfast

Birmingham

Exeter

Glasgow

Leeds

Liverpool

London

Manchester

Newcastle upon Tyne

Penarth

Sheffield

Southampton

Stoke-on-Trent

All Listed Sponsors
lead

Vertex Pharmaceuticals Incorporated

INDUSTRY

NCT02565914 - A Study to Evaluate the Safety and Efficacy of Long Term Treatment With VX-661 in Combination With Ivacaftor in Participants With Cystic Fibrosis Who Have an F508del-CFTR Mutation | Biotech Hunter | Biotech Hunter