73
Participants
Start Date
October 31, 2015
Primary Completion Date
February 29, 2016
Study Completion Date
August 31, 2016
FLUAD® influenza vaccine
MF59 adjuvant has been used in seasonal influenza vaccine in Canada and Europe for people ≥65 years. MF59 contains squalene, polysorbate 80, and sorbitan trioleate. It is packaged as small microvesicles of 160nm diameter. The complete mechanism of action of MF59 is not well understood but requires activation of the innate immune system; the adjuvant exerts a local inflammatory response increasing the influx of neutrophils and macrophages to the injection site.
FLUVIRAL®
Standard 2015-2016 nonadjuvanted vaccine
University Health Network, Toronto
OTHER