500
Participants
Start Date
September 30, 2015
Primary Completion Date
September 30, 2030
Study Completion Date
September 30, 2035
Ceritinib
One of the following drugs will be chosen for each subject based on molecular guided results: Ceritinib, dasatinib, sorafenib or vorinostat. This will be followed by consolidation, immunotherapy +/- DFMO, and then all subjects will receive DFMO for 2 years as maintenance.
dasatinib
One of the following drugs will be chosen for each subject based on molecular guided results: Ceritinib, dasatinib, sorafenib or vorinostat. This will be followed by consolidation, immunotherapy +/- DFMO, and then all subjects will receive DFMO for 2 years as maintenance.
sorafenib
One of the following drugs will be chosen for each subject based on molecular guided results: Ceritinib, dasatinib, sorafenib or vorinostat. This will be followed by consolidation, immunotherapy +/- DFMO, and then all subjects will receive DFMO for 2 years as maintenance.
vorinostat
One of the following drugs will be chosen for each subject based on molecular guided results: Ceritinib, dasatinib, sorafenib or vorinostat. This will be followed by consolidation, immunotherapy +/- DFMO, and then all subjects will receive DFMO for 2 years as maintenance.
DFMO
DFMO will be given to Arm B during immunotherapy and then for 2 years as maintenance to all subjects completing immunotherapy.
RECRUITING
Penn State Milton S. Hershey Medical Center and Children's Hospital, Hershey
RECRUITING
Levine Children's Hospital, Charlotte
RECRUITING
Medical University of South Carolina, Charleston
RECRUITING
Arnold Palmer Hospital for Children, Orlando
RECRUITING
St. Joseph's Children's Hospital, Tampa
RECRUITING
Helen DeVos Children's Hospital, Grand Rapids
RECRUITING
Children's Hospital and Clinics of Minnesota, Minneapolis
RECRUITING
Cardinal Glennon Children's Medical Center, St Louis
COMPLETED
Children's Mercy Hospitals and Clinics, Kansas City
RECRUITING
Arkansas Children's Hospital, Little Rock
RECRUITING
Children's Medical Center, Dallas
RECRUITING
Dell Children's Blood and Cancer Center, Austin
RECRUITING
Rady Children's Hospital, San Diego
RECRUITING
Kapiolani Medical Center for Women and Children, Honolulu
RECRUITING
University of Alabama, Children's of Alabama, Birmingham
RECRUITING
UCSF Benioff Children's Hospital Oakland-, Oakland
RECRUITING
Nicklaus Children's Miami, Miami
RECRUITING
Augusta University Health, Augusta
RECRUITING
St. Lukes, Boise
RECRUITING
Advocate Children's Medical Group, Chicago
RECRUITING
University of Louisville, Louisville
RECRUITING
Hackensack University Medical Center, Hackensack
RECRUITING
Randall Children's Hospital, Portland
NOT_YET_RECRUITING
Children's Hospital of The King's Daughters, Norfolk
RECRUITING
UHC Sainte-Justine, Montreal
RECRUITING
Connecticut Children's Hospital, Hartford
Collaborators (1)
Dell, Inc.
INDUSTRY
Beat NB Cancer Foundation
OTHER
K C Pharmaceuticals Inc.
INDUSTRY
Team Parker for Life
UNKNOWN
Giselle Sholler
OTHER