Effects of Sevoflurane and Desflurane on Treg

PHASE2CompletedINTERVENTIONAL
Enrollment

40

Participants

Timeline

Start Date

August 10, 2015

Primary Completion Date

June 3, 2017

Study Completion Date

June 3, 2017

Conditions
Transplant; Failure, Kidney
Interventions
DRUG

Sevoflurane

After induction of anesthesia and successful intubation, 2 L/min N2O, 2 L/min O2 , and 2% to 2.5% sevoflurane will be given for 10 minutes then total flow will be decreased to 2 L/min. Anesthesia will be maintained using 1-1.5 minimal alveolar concentration (MAC) of sevoflurane in 50% O2 and 50% N2O. Ventilation will be adjusted to keep end-tidal carbon dioxide 30-35 mmHg (Tidal volume 7-10 mL/kg).

DRUG

Desflurane

After induction of anesthesia and successful intubation, 2 L/min N2O, 2 L/min O2 , and 6% to 8% desflurane will be given for 10 minutes then total flow will be decreased to 2 L/min. Anesthesia will be maintained using 1-1.5 minimal alveolar concentration (MAC) of desflurane in 50% O2 and 50% N2O. Ventilation will be adjusted to keep end-tidal carbon dioxide 30-35 mmHg (Tidal volume 7-10 mL/kg).

Trial Locations (1)

10400

Ramathibodi Hospital, Ratchathewi

All Listed Sponsors
lead

Mahidol University

OTHER

NCT02559297 - Effects of Sevoflurane and Desflurane on Treg | Biotech Hunter | Biotech Hunter