Comparison of Sacubitril/Valsartan Versus Enalapril on Effect on NT-proBNP in Patients Stabilized From an Acute Heart Failure Episode.

PHASE4CompletedINTERVENTIONAL
Enrollment

887

Participants

Timeline

Start Date

April 29, 2016

Primary Completion Date

June 29, 2018

Study Completion Date

July 24, 2018

Conditions
Acute Heart Failure
Interventions
DRUG

sacubitril/valsartan (LCZ696)

sacubitril/valsartan (LCZ696) tablet with minimum dose 24/26 mg, maximum dose 97/103 mg twice daily administered orally.

DRUG

Enalapril

Enalapril tablet with minimum dose 2.5 mg, maximum dose 10 mg twice daily administered orally.

DRUG

sacubitril/valsartan (LCZ696) matching placebo

matching placebo of sacubitril/valsartan (LCZ696) tablet with minimum dose 24/26 mg, maximum dose 97/103 mg twice daily administered orally.

DRUG

enalapril matching placebo

enalapril matching placebo tablet with minimum dose 2.5 mg, maximum dose 10 mg twice daily administered orally.

Trial Locations (123)

10016

Novartis Investigative Site, New York

10029

Novartis Investigative Site, New York

10032

Novartis Investigative Site, New York

10310

Novartis Investigative Site, Staten Island

10461

Novartis Investigative Site, The Bronx

11030

Novartis Investigative Site, Manhasset

11215

Novartis Investigative Site, Brooklyn

12601

Novartis Investigative Site, Poughkeepsie

13790

Novartis Investigative Site, Johnson City

14215

Novartis Investigative Site, Buffalo

14621

Novartis Investigative Site, Rochester

15065

Novartis Investigative Site, Natrona Heights

17011

Novartis Investigative Site, Camp Hill

19001

Novartis Investigative Site, Abington

20422

Novartis Investigative Site, Washington D.C.

21215

Novartis Investigative Site, Baltimore

21401

Novartis Investigative Site, Annapolis

22908

Novartis Investigative Site, Charlottesville

23298

Novartis Investigative Site, Richmond

23454

Novartis Investigative Site, Virginia Beach

24501

Novartis Investigative Site, Lynchburg

26301

Novartis Investigative Site, Clarksburg

27157

Novartis Investigative Site, Winston-Salem

27599

Novartis Investigative Site, Chapel Hill

27834

Novartis Investigative Site, Greenville

29403

Novartis Investigative Site, Charleston

29615

Novartis Investigative Site, Greenville

30060

Novartis Investigative Site, Marietta

30901

Novartis Investigative Site, Augusta

31201

Novartis Investigative Site, Macon

32117

Novartis Investigative Site, Daytona Beach

32216

Novartis Investigative Site, Jacksonville

32608

Novartis Investigative Site, Gainesville

32610

Novartis Investigative Site, Gainesville

32960

Novartis Investigative Site, Vero Beach

33021

Novartis Investigative Site, Hollywood

33308

Novartis Investigative Site, Fort Lauderdale

33462

Novartis Investigative Site, Atlantis

33612

Novartis Investigative Site, Tampa

33805

Novartis Investigative Site, Lakeland

33881

Novartis Investigative Site, Winter Haven

34239

Novartis Investigative Site, Sarasota

34667

Novartis Investigative Site, Tampa

35294

Novartis Investigative Site, Birmingham

37203

Novartis Investigative Site, Nashville

37212

Novartis Investigative Site, Nashville

39216

Novartis Investigative Site, Jackson

39401

Novartis Investigative Site, Hattiesburg

40205

Novartis Investigative Site, Louisville

40245

Novartis Investigative Site, Louisville

43608

Novartis Investigative Site, Toledo

45220

Novartis Investigative Site, Cincinnati

46202

Novartis Investigative Site, Indianapolis

46237

Novartis Investigative Site, Indianapolis

46514

Novartis Investigative Site, Elkhart

47374

Novartis Investigative Site, Richmond

48106

Novartis Investigative Site, Ann Arbor

48201

Novartis Investigative Site, Detroit

48708

Novartis Investigative Site, Bay City

50314

Novartis Investigative Site, Des Moines

54401

Novartis Investigative Site, Wausau

55101

Novartis Investigative Site, Saint Paul

55102

Novartis Investigative Site, Saint Paul

55109

Novartis Investigative Site, Maplewood

55417

Novartis Investigative Site, Minneapolis

57701

Novartis Investigative Site, Rapid City

58201

Novartis Investigative Site, Grand Forks

60007

Novartis Investigative Site, Elk Grove Village

60068

Novartis Investigative Site, Park Ridge

60181

Novartis Investigative Site, Oakbrook Terrace

60190

Novartis Investigative Site, Winfield

60504

Novartis Investigative Site, Aurora

61606

Novartis Investigative Site, Peoria

61614

Novartis Investigative Site, Peoria

64108

Novartis Investigative Site, Kansas City

66103

Novartis Investigative Site, Kansas City

68198

Novartis Investigative Site, Omaha

70458

Novartis Investigative Site, Slidell

70808

Novartis Investigative Site, Baton Rouge

71301

Novartis Investigative Site, Alexandria

72205

Novartis Investigative Site, Little Rock

72901

Novartis Investigative Site, Fort Smith

73122

Novartis Investigative Site, Oklahoma City

74104

Novartis Investigative Site, Tulsa

75093

Novartis Investigative Site, Plano

75204

Novartis Investigative Site, Dallas

75390

Novartis Investigative Site, Dallas

77030

Novartis Investigative Site, Houston

78229

Novartis Investigative Site, San Antonio

80120

Novartis Investigative Site, Littleton

83702

Novartis Investigative Site, Boise

89502

Novartis Investigative Site, Reno

90033

Novartis Investigative Site, Los Angeles

90073

Novartis Investigative Site, Los Angeles

90806

Novartis Investigative Site, Long Beach

91105

Novartis Investigative Site, Pasadena

91108

Novartis Investigative Site, San Marino

92123

Novartis Investigative Site, San Diego

92868

Novartis Investigative Site, Orange

93301

Novartis Investigative Site, Bakersfield

93701

Novartis Investigative Site, Fresno

94305

Novartis Investigative Site, Stanford

94806

Novartis Investigative Site, San Pablo

95817-1460

Novartis Investigative Site, Sacramento

Unknown

Novartis Investigative Site, Denver

Novartis Investigative Site, Boston

06610

Novartis Investigative Site, Bridgeport

06102

Novartis Investigative Site, Hartford

06105

Novartis Investigative Site, Hartford

06516

Novartis Investigative Site, West Haven

32209-6511

Novartis Investigative Site, Jacksonville

47303-3400

Novartis Investigative Site, Muncie

04401

Novartis Investigative Site, Bangor

02215

Novartis Investigative Site, Boston

08103-3117

Novartis Investigative Site, Camden

08318

Novartis Investigative Site, Elmer

08035

Novartis Investigative Site, Haddon Heights

07102

Novartis Investigative Site, Newark

10467-2490

Novartis Investigative Site, The Bronx

19102 2293

Novartis Investigative Site, Philadelphia

02903

Novartis Investigative Site, Providence

05009

Novartis Investigative Site, White River Junction

53792-1615

Novartis Investigative Site, Madison

Sponsors
All Listed Sponsors
lead

Novartis Pharmaceuticals

INDUSTRY