Phase III Open Label Study of MEDI 4736 With/Without Tremelimumab Versus Standard of Care (SOC) in Recurrent/Metastatic Head and Neck Cancer

PHASE3CompletedINTERVENTIONAL
Enrollment

823

Participants

Timeline

Start Date

October 15, 2015

Primary Completion Date

July 6, 2020

Study Completion Date

May 21, 2021

Conditions
Squamous Cell Carcinoma of the Head and Neck
Interventions
BIOLOGICAL

MEDI4736

Anti-PD-L1 antibody

BIOLOGICAL

Tremelimumab

Anti-CTLA-4 Antibody

BIOLOGICAL

MEDI4736+Tremelimumab

BIOLOGICAL

Cetuximab

Monoclonal Antibody

DRUG

5-fluorouracil (5FU)

Chemotherapy Agent

DRUG

Cisplatin

Chemotherapy agent

DRUG

Carboplatin

Chemotherapy Agent

Trial Locations (197)

100

Research Site, Taipei

704

Research Site, Tainan City

1000

Research Site, Brussels

1090

Research Site, Brussels

1112

Research Site, Quezon City

1140

Research Site, Vienna

1200

Research Site, Brussels

1740

Research Site, Las Piñas

3000

Research Site, Leuven

4010

Research Site, Linz

5000

Research Site, Namur

6000

Research Site, Cebu City

6020

Research Site, Innsbruck

8036

Research Site, Graz

10029

Research Site, New York

10065

Research Site, New York

10126

Research Site, Torino

10330

Research Site, Bangkok

10449

Research Site, Taipei

10700

Research Site, Bangkok

11217

Research Site, Taipei

11527

Research Site, Athens

12120

Research Site, Pathum Thani

12203

Research Site, Berlin

13620

Research Site, Seongnam-si

16499

Research Site, Suwon

18547

Research Site, Athens

20007

Research Site, Washington D.C.

20133

Research Site, Milan

20246

Research Site, Hamburg

21029

Research Site, Vinnytsia

21079

Research Site, Dijon

21201

Research Site, Baltimore

21231

Research Site, Baltimore

21565

Research Site, Incheon

23007

Research Site, Jaén

25006

Research Site, Kirovohrad

27157

Research Site, Winston-Salem

27599

Research Site, Chapel Hill

28007

Research Site, Madrid

28034

Research Site, Madrid

28040

Research Site, Madrid

28050

Research Site, Madrid

28204

Research Site, Charlotte

28644

Research Site, Cheongju-si

29010

Research Site, Málaga

29200

Research Site, Brest

29600

Research Site, Marbella

30322

Research Site, Atlanta

31059

Research Site, Toulouse

33000

Research Site, Bordeaux

33612

Research Site, Tampa

33705

Research Site, St. Petersburg

33916

Research Site, Fort Myers

35128

Research Site, Padua

37203

Research Site, Nashville

40022

Research Site, Sumy

40447

Research Site, Taichung

40705

Research Site, Taichung

43210

Research Site, Columbus

44115

Research Site, Cleveland

44124

Research Site, Cona

45147

Research Site, Essen

46026

Research Site, Valencia

49102

Research Site, Dnipro

49241

Research Site, Seogu

50009

Research Site, Zaragoza

50048

Research Site, Kryvyi Rih

50134

Research Site, Florence

50200

Research Site, Chiang Mai

53100

Research Site, Siena

54519

Research Site, Vandœuvre-lès-Nancy

54645

Research Site, Thessaloniki

55131

Research Site, Mainz

58128

Research Site, Hwasun-gun

60590

Research Site, Frankfurt am Main

60637

Research Site, Chicago

61070

Research Site, Kharkiv Region

65055

Research Site, Odesa

69120

Research Site, Heidelberg

69373

Research Site, Lyon

72076

Research Site, Tübingen

75015

Research Site, Paris

76018

Research Site, Ivano-Frankivsk

79106

Research Site, Freiburg im Breisgau

80045

Research Site, Aurora

84131

Research Site, Salerno

86021

Research Site, Poitiers

90110

Research Site, Hat Yai

90127

Research Site, Palermo

91054

Research Site, Erlangen

94800

Research Site, Villejuif

97070

Research Site, Würzburg

98158

Research Site, Messina

100000

Research Site, Hanoi

Research Site, Hà Nội

122001

Research Site, Gūrgaon

125367

Research Site, Moscow

163045

Research Site, Arkhangelsk

191014

Research Site, Saint Petersburg

195271

Research Site, Saint Petersburg

197758

Research Site, Saint Petersburg

198255

Research Site, Saint Petersburg

249036

Research Site, Obninsk

350040

Research Site, Krasnodar

354057

Research Site, Sochi

388325

Research Site, Karamsad

411001

Research Site, Pune

450054

Research Site, Ufa

560027

Research Site, Bangalore

560076

Research Site, Bangalore

Research Site, Bengaluru

620905

Research Site, Yekaterinburg

625107

Research Site, Madurai

644013

Research Site, Omsk

700000

Research Site, Ho Chi Minh City

720237

Research Site, Suceava

02215

Research Site, Boston

07960

Research Site, Morristown

14784-400

Research Site, Barretos

81520-060

Research Site, Curitiba

88034-000

Research Site, Florianópolis

98700-000

Research Site, Ijuí

90035-003

Research Site, Porto Alegre

90619-900

Research Site, Porto Alegre

91350-200

Research Site, Porto Alegre

50040-000

Research Site, Recife

22793-080

Research Site, Rio de Janeiro

09060-650

Research Site, Santo André

09080-110

Research Site, Santo André

15090-000

Research Site, São José do Rio Preto

03102-002

Research Site, São Paulo

T2N 4N2

Research Site, Calgary

R3E 0V9

Research Site, Winnipeg

E1C 8X3

Research Site, Moncton

B3H 1V7

Research Site, Halifax

L8V 5C2

Research Site, Hamilton

N6A 4L6

Research Site, London

K1H 8L6

Research Site, Ottawa

M5G 2M9

Research Site, Toronto

H4A 3J1

Research Site, Montreal

06100

Research Site, Nice

115 22

Research Site, Athens

124 61

Research Site, Athens

711 11

Research Site, Heraklion

673-8558

Research Site, Akashi-shi

260-8717

Research Site, Chiba

811-1347

Research Site, Fukuoka

573-1191

Research Site, Hirakata-shi

259-1193

Research Site, Isehara-shi

890-8520

Research Site, Kagoshima

920-8650

Research Site, Kanazawa

362-0806

Research Site, Kitaadachi-gun

650-0017

Research Site, Kobe

135-8550

Research Site, Kōtoku

981-1293

Research Site, Natori-shi

700-8558

Research Site, Okayama

541-8567

Research Site, Osaka

003-0804

Research Site, Sapporo

060-8648

Research Site, Sapporo

589-8511

Research Site, Sayama

411-8777

Research Site, Sunto-gun

569-8686

Research Site, Takatsuki-shi

470-1192

Research Site, Toyoake-shi

241-8515

Research Site, Yokohama

15-027

Research Site, Bialystok

43-300

Research Site, Bielsko-Biala

80-214

Research Site, Gdansk

81-519

Research Site, Gdynia

93-513

Research Site, Lodz

20-090

Research Site, Lublin

60-780

Research Site, Poznan

61-866

Research Site, Poznan

71-730

Research Site, Szczecin

02-781

Research Site, Warsaw

833 01

Research Site, Bratislava

041 91

Research Site, Košice

03080

Research Site, Seoul

03722

Research Site, Seoul

05505

Research Site, Seoul

135-710

Research Site, Seoul

06008

Research Site, Badajoz

08035

Research Site, Barcelona

08036

Research Site, Barcelona

08907

Research Site, L'Hospitalet de Llobregat

Unknown

Research Site, Kaohsiung City

Research Site, Hanoi

08111

Research Site, Kapitanivka Village

03022

Research Site, Kyiv

03115

Research Site, Kyiv

CH63 4JY

Research Site, Bebington

B15 2TT

Research Site, Birmingham

EC1A 7BE

Research Site, London

SW3 6JJ

Research Site, London

M20 4BX

Research Site, Manchester

SM2 5PT

Research Site, Sutton

TA1 5DA

Research Site, Taunton

Sponsors

Lead Sponsor

All Listed Sponsors
lead

AstraZeneca

INDUSTRY