102
Participants
Start Date
October 27, 2015
Primary Completion Date
February 14, 2017
Study Completion Date
September 21, 2021
23-PPV
The 23-PPV vaccine will be given as a 0.5-milliliter (mL) intramuscular (IM) injection in the deltoid muscle on Day 112 (Group A) or Day 28 (Group B).
13-PCV Booster
The 13-PCV booster will be given as an IM injection in the deltoid muscle on Day 140 (select participants in Group A).
Influenza Vaccine
The influenza vaccine will be given as an IM injection in the deltoid muscle at any time between Day 85 and Day 144 (select participants in Group A) or any time between Day 1 and Day 85 (Group B).
KLH
KLH will be given as a 1-mg subcutaneous (SC) injection on Days 84, 112, and 140 (Group A) or Days 1, 28, and 56 (Group B).
OCR
OCR will be given as an intravenous (IV) infusion at a dose of 600 mg, with the first dose given as two infusions of 300mg 14 days apart, according to the specifications described in the corresponding Group A and Group B arms.
TT Vaccine
The TT-containing adsorbed vaccine will be given as a 0.5-mL IM injection in the deltoid muscle on Day 85 (Group A) or Day 1 (Group B).
Staten Island Univ Hospital, Staten Island
Abington Neurological Associates, Abington
Neurology Associates PA, Hickory
University of Miami School of Medicine; Dept. of Neurology Movement Disorder Center, Miami
University of South Florida, Tampa
North Central Neurology Associates, Cullman
Neurology Clinic PC, Cordova
MDH Research LLC, Westerville
Ohio Health Research Institute Grant Medical Center, Columbus
Michigan Institute for Neurological Disorders, Farmington Hills
The Minneapolis Clinic of Neurology, Golden Valley
Mercy Hospital St. Louis / Mercy Clinic Neurology, Chesterfield
Central Texas Neurology Consultants, Round Rock
Rocky Mountain MS Clinic, Salt Lake City
Territory Neurology and Research Institute, Tucson
University of New Mexico, Albuquerque
Cleveland Clinic Lou Ruvo; Center for Brain Research, Las Vegas
Scripps Clinic, La Jolla
Fullerton Neurology and Headache Center, Fullerton
Swedish Medical Center, Seattle
University of Calgary, Calgary
University of British Columbia Hospital; Division of Neurology, Vancouver
Hoffmann-La Roche
INDUSTRY