Cardiac Remodeling and Circulating Biomarkers in Pediatric Left Ventricular Pressure Loading Lesions

CompletedOBSERVATIONAL
Enrollment

31

Participants

Timeline

Start Date

August 31, 2015

Primary Completion Date

December 31, 2017

Study Completion Date

December 31, 2020

Conditions
Coarctation of AortaAortic StenosisCardiac Hypertrophy
Interventions
PROCEDURE

Echocardiogram

2 and 3-dimensional echocardiographic images will be obtained to estimate LV mass, ejection fraction (Simpson's biplane), fractional shortening (M mode Doppler), and pulse-wave estimated pressure gradient across the outflow obstruction.

BIOLOGICAL

Serology

protein analysis targeting several potential protein biomarkers for cardiac remodeling and hypertrophy as well as targeting known miRNAs.

Trial Locations (1)

80045

Children's Hospital Colorado, Denver

All Listed Sponsors
lead

University of Colorado, Denver

OTHER

NCT02545790 - Cardiac Remodeling and Circulating Biomarkers in Pediatric Left Ventricular Pressure Loading Lesions | Biotech Hunter | Biotech Hunter