A Study to Evaluate A Range of Dose Levels of Ad26.ZEBOV and MVA-BN-Filo in Healthy Adult Participants

PHASE3CompletedINTERVENTIONAL
Enrollment

525

Participants

Timeline

Start Date

September 21, 2015

Primary Completion Date

June 7, 2016

Study Completion Date

November 29, 2016

Conditions
Healthy
Interventions
BIOLOGICAL

Ad26.ZEBOV 5*10^10 viral particles (vp)

Ad26.ZEBOV, live, replication incompetent vaccine, sterile suspension for intramuscular (IM) injection of 5\*10\^10 viral particles on Day 1

BIOLOGICAL

Ad26.ZEBOV 2*10^10 (vp)

Ad26.ZEBOV, live, replication incompetent vaccine, sterile suspension for intramuscular (IM) injection of 2\*10\^10 viral particles on Day 1

BIOLOGICAL

Ad26.ZEBOV 0.8*10^10 (vp)

Ad26.ZEBOV, live, replication incompetent vaccine, sterile suspension for intramuscular (IM) injection of 0.8\*10\^10 viral particles on Day 1

BIOLOGICAL

MVA-BN-Filo 1*10^8 Infectious Unit [Inf. U.]

MVA-BN-Filo- live replication incompetent vaccine, IM injection of 1\*10\^8 Infectious Unit \[Inf. U.\] once on Day 57

BIOLOGICAL

MVA-BN-Filo 5*10^7 Inf. U.

MVA-BN-Filo- live replication incompetent vaccine, IM injection of 5\*10\^7 Inf. U. once on Day 57

BIOLOGICAL

Placebo

One 0.5 ml IM injection of 0.9% saline administered once on Day 1 and Day 57

Trial Locations (6)

Unknown

Huntsville

San Diego

Melbourne

Peoria

Mishawaka

Rockville

All Listed Sponsors
lead

Janssen Vaccines & Prevention B.V.

INDUSTRY

NCT02543567 - A Study to Evaluate A Range of Dose Levels of Ad26.ZEBOV and MVA-BN-Filo in Healthy Adult Participants | Biotech Hunter | Biotech Hunter