Liver Immune Tolerance Marker Utilization Study

NACompletedINTERVENTIONAL
Enrollment

69

Participants

Timeline

Start Date

April 30, 2015

Primary Completion Date

May 31, 2021

Study Completion Date

May 31, 2021

Conditions
ImmunosuppressionImmune Tolerance
Interventions
OTHER

Controlled weaning of immunosuppression

At week 0 patients have liver biopsy and liver functional tests (LFTs). Week 1-4 medication reduction to 1.5mg Tacrolimus (Tac) daily or 150mg Cyclosporine A (CsA). At week 4 LFTs. Week 5-8 medication reduction to 1mg Tac / 100mg CsA. Week 8 LFTs. Week 9-12 reduction to 0.5mg Tac/ 50mg CsA. Week 12 LFTs. Week 13-16 reduction to 0mg. Week 16 liver biopsy \& LFTs. Weekly LFTs performed Week 17-20. Monthly LFTs for the next 3 months. LFTs every 3 months for monitoring.

Trial Locations (1)

M5G 2C4

Toronto General Hospital, Toronto

All Listed Sponsors
lead

University of Toronto

OTHER

NCT02541916 - Liver Immune Tolerance Marker Utilization Study | Biotech Hunter | Biotech Hunter