Impact of Chronic Kidney Disease on the Effects of Ticagrelor in Patients With Diabetes and Coronary Artery Disease

PHASE4CompletedINTERVENTIONAL
Enrollment

101

Participants

Timeline

Start Date

February 29, 2016

Primary Completion Date

November 14, 2019

Study Completion Date

June 17, 2020

Conditions
Coronary Artery DiseaseDiabetes Mellitus
Interventions
DRUG

ticagrelor

Diabetic patients with or without chronic kidney disease will be randomized 1:1 to either (A) standard dose (90mg twice daily of ticagrelor) for 7-10 days and then cross-over to low dose (60mg twice daily of ticagrelor) for 7-10 days; (B) low dose (60mg twice daily of ticagrelor) for 7-10 days (phase 1) and then cross-over to standard dose (90mg twice daily of ticagrelor) for 7-10 days (phase 2).

Trial Locations (1)

32209

University of Florida, Jacksonville

All Listed Sponsors
lead

University of Florida

OTHER

NCT02539160 - Impact of Chronic Kidney Disease on the Effects of Ticagrelor in Patients With Diabetes and Coronary Artery Disease | Biotech Hunter | Biotech Hunter