Longitudinal Cohort Study in Participants With Severe Asthma to Assess Biomarkers

PHASE4CompletedINTERVENTIONAL
Enrollment

483

Participants

Timeline

Start Date

August 28, 2015

Primary Completion Date

July 10, 2017

Study Completion Date

July 10, 2017

Conditions
Asthma
Interventions
DRUG

FP

ICS consisting of FP will be administered by DPI (or equivalent) as per investigator discretion.

DRUG

LABA

LABA will be administered as per investigator discretion.

DRUG

LTRA

LTRA will be administered as per investigator discretion.

DRUG

LAMA

LAMA will be administered as per investigator discretion.

DRUG

Theophylline

Theophylline will be administered as per investigator discretion.

DRUG

Oral Corticosteroids

Oral corticosteroids will be administered as per investigator discretion.

Trial Locations (100)

1036

Synexus Magyarorszag Kft, Budapest

1038

Clinical Hospital Gailezers; Dept of Pulmonology, Riga

1070

Hospital Erasme; Neurologie, Brussels

1122

Szent János Kórház; Tüdőgondozó Intézet és Szűrőállomás, Budapest

2400

Lungemedicinsk afd. L, Bispebjerg Hospital, København NV

2650

Hvidovre Hospital, Lungemedicinsk Afdeling, Hvidovre

2660

Dr. Kenessey Albert Korhaz Es Rendelointezet; Tudoosztaly (Pulmonolgy Dept ), Balassagyarmat

3000

UZ Leuven Gasthuisberg, Leuven

3233

Matrai Állami Gyógyintézet ; Bronchológia, Mátraháza

4000

CHU Sart-Tilman, Liège

4032

Debrecen Uni Medical School; Dept of Pulmonary Medicine, Debrecen

5100

Private Practice, Jambes

5530

CHU UCL Mont-Godinne, Mont-godinne

5800

Mhat - Pleven; Clinic of Pulmonology, Pleven

7002

Specialized Hospital for Active Treatment for pneumo-phtysiatric diseases, Rousse

10016

Laura and ISAAC Perlmutter Cancer Center at NYU Langone., New York

10126

AOU Città della Salute e della Scienza di Torino - Ospedale Le Molinette; SC Pneumologia, Turin

10461

Montefiore Medical Center, The Bronx

11501

Winthrop University Hospital, Mineola

11725

Island Medical Research Pc, Commack

12159

Institut für Allergie- und Asthmaforschung Berlin, IAAB, Berlin

15241

Allergy & Clinical Immun Assoc, Pittsburgh

15706

Complexo Hospitalario Universitario de Santiago, Santiago de Compostela

16132

IRCCS AOU SAN MARTINO - IST;UO ALLERGOLOGIA-IMMUNOPATOLOGIA RESPIRATORIA e TERAPIE BIOTECNOLOGICHE, Genoa

17033

Penn State Milton S. Hershey Medical Center, Hershey

19422

Allergy-Asthma Specialists PC, Blue Bell

19610

Berks-Schuylkill Respiratory Specialists, Ltd, Wyomissing

22030

O & O Alpan, LLC, Fairfax

22903

Northridge Internal Medicine, Charlottesville

28041

Hospital Universitario 12 de Octubre; Servicio de Neumologia, Madrid

28222

Hospital Universitario Puerta de Hierro Majadahonda; Servicio de Neumología, Majadahonda

30173

Pneumologicum, Hanover

31707

Georgia Pollens Clinical Research Centers, Albany

33134

AAADRS; Clinical Research Center, Coral Gables

33613

University of South Florida, Tampa

33952

Volunteer Medical Research, Port Charlotte

35209

Clinical Research Center of Alabama, LLC, Birmingham

41124

Policlinico di Modena; Oncologia, Ematologia e Patologie dell'apparato Respiratorio, Modena

44789

Berufsgenossenschaftliches Uni-Klinikum Bergmannsheil GmbH, Bochum

45239

Ruhrlandklinik Lungenzentrum der UNI Essen Abt.Pneumologie-Allergologie, Essen

48960

Hospital de Galdakano; Servicio de Neumologia, Galdakano

55131

Universitätsmedizin der Johannes Gutenberg-Universität Mainz, Medizinische Klinik, Pneumologie, Mainz

56068

KPPK Studienzentrum GmbH; Dr. med. A. Kroker, Dr. med. O. Schmidt, Koblenz

56124

A.O. Universitaria Pisana-Ospedale Cisanello; Dipartimento Cardio Toracico-Pneumologia Ii, Pisa

64283

Lungenzentrum Darmstadt, Darmstadt

66100

Presidio Ospedaliero SS. Annunziata di Chieti ; Dip. Medico-UOSD Allergologia, Chieti

68046

Asthma & Allergy Center, P.C., Papillion

74136

Vital Prospects Clin Res Pc, Tulsa

75877

Hopital Bichat Claude Bernard ; Service de Pneumologie, Paris

77030

Baylor College of Medicine, Houston

78251

Allergy & Asthma Res Ctr PA, San Antonio

79106

Universitätsklinikum Freiburg, Abteilung Pneumologie, Freiburg im Breisgau

81377

Klinikum der Universität München; Campus Großhadern; Med. Klinik und Poliklinik V, München

84107

Allergy Associates of Utah, Murray

84341

Bridgerland Clinical Research, North Logan

90146

A.O. Ospedali Riuniti; Villa Sofia-Cervello di Palermo; U. O. Pneumologia 2 - Padiglione B, Palermo

92108

Allergy Assoc Medical Group, San Diego

92691

Southern California Research Center, Mission Viejo

95123

Azienda Policlinico Vittorio Emanuele; Pneumologia Riabilitativa E Allergologia, Catania

95819

Capital Allergy Resp Dis Ctr, Sacramento

98105

ASTHMA, Inc, Seattle

99204

Pulmonary & Sleep Research, Spokane

115478

"FSBI National Research Center - Institute of Immunology of FMBA of Russia", Moscow

125993

SBEI APE Russian Medical Academy of Post-graduate Education; Department of Clinical Allergology, Moscow

197706

City Hospital #40 of Resort Administrative District, Saint Petersburg

198328

City Out-patient Clinic #106, Saint Petersburg

410012

Saratov State Medical University; Chair Of Clinical Allergology, Saratov

603126

"SBHI of NN region RCH of NN n.a. N.A.Semashko", Nizhny Novgorod

650002

Research Institute of Complex Cardiovascular Pathology, Kemerovo

06520

Yale New Haven Hospital, New Haven

06708

Waterbury Pulmonary Associates, Waterbury

08054

Allergy & Asthma Research of Nj, Inc, Mount Laurel

V5Z 1L7

Vancouver General Hosp; The Lung Centre, Vancouver

V6Z 1Y6

St. Paul's Hospital University of British Colambia Division of Hematology, Vancouver

L7N 3V2

Burlington Lung Clinic, Burlington

K7L 2V6

Kingston General Hospital, Kingston

M5T 3A9

Inspiration Research Limited, Toronto

H2X 3E4

Centre Hospitalier de l'Université de Montréal (CHUM), Montreal

H3T 1E2

Jewish General Hospital; Endoscopy Department, Montreal

G1V 4G5

Hopital Laval; Centre de Pneumologie, Québec

LV-1001

Riga 1st hospital, outpatient clinic Bruninieks, Riga

LV-1011

Latvian University postgraduate institute, Riga

2134 TM

Spaarne Ziekenhuis Hoofddorp; Long Geneeskunde, Hoofddorp

8934 AD

Medisch Centrum Leeuwarden; Longziekten, Leeuwarden

3435 CM

St. Antonius; R&D Long, Nieuwegein

4434-502

CHVNG/E_Unidade 1; Servico de Pneumologia, Vila Nova de Gaia

Unknown

"SBIH Clinical dermatovenerologic dispensary of Ministry of Health of the Krasnodar region", Krasnodar

"SBEI HPE North Ossetian State Medical Academy of Ministry of Health of Russia", Vladikavkaz

Hospital Universitario Reina Sofia; Servicio de Neumología, Córdoba

08006

Fundacio Santa Creu I Sant Pau, Barcelona

08036

Hospital Clinic I provincial; Servicio de Neumologia, Barcelona

B15 2TH

Queen Elizabeth Hospital, Birmingham

BD9 6RJ

Bradford Royal Infirmary, Bradford

GL1 3NN

Gloucestershire Royal Hospital, Gloucester

EC1M 6BQ

William Harvey Research Institute, London

SW17 0QT

St George's Hospital, London

M8 5RB

North Manchester Hospital; Respiratory Department, Manchester

NE7 7DN

Freeman Hospital; Respiratory Department; Sir William Leach Lung Research Centre, Newcastle upon Tyne

PO6 3LY

Queen Alexandra Hospital, Portsmouth, Portsmouth

SY3 8XQ

Royal Shrewsbury Hospital, Shrewsbury

All Listed Sponsors
lead

Hoffmann-La Roche

INDUSTRY

NCT02537691 - Longitudinal Cohort Study in Participants With Severe Asthma to Assess Biomarkers | Biotech Hunter | Biotech Hunter