Platelet Inhibition After Pre-hospital Ticagrelor Using Fentanyl Compared to Morphine in Patients With ST-segment Elevation Myocardial Infarction Undergoing Primary Percutaneous Coronary Intervention

Analgesia protocol using Fentanyl (initial dose: 50-100 mcg, additional doses of 25 mcg every 2-5 minutes to achieve adequate sedation, if required).

Analgesia protocol using Morphine (initial dose: 4-8 mg, additional doses of 2 mg every 5-15 minutes to achieve adequate sedation, if required).

Pre-hospital Ticagrelor loading dose of 180 mg administered orally, followed by 90 mg bid

500 mg loading dose orally (or intravenously), followed by 100 mg od

5'000 IU loading dose intravenously, additional doses to achieve an ACT \>250 sec during PCI are allowed.

Primary PCI with stent implantation according to the guidelines of the European Society of Cardiology.