Deceased Organ Donor Interventions to Protect Kidney Graft Function

NACompletedINTERVENTIONAL
Enrollment

1,427

Participants

Timeline

Start Date

July 26, 2017

Primary Completion Date

June 1, 2022

Study Completion Date

June 1, 2022

Conditions
Brain DeathOrgan DonationOrgan Transplant Failure or RejectionDelayed Graft Function
Interventions
OTHER

Pump Eligible - Normothermia - Pump Both Kidneys

Normothermia and Machine Perfusion Deceased Donors will be kept normothermic (36.5-37.5 C) prior to organ recovery. Recovered kidneys will receive machine perfusion prior to implantation.OPO's protocol

OTHER

Pump Eligible - Hypothermia and Pump Right Kidney

"Deceased Donors will be kept mildly hypothermic (34-35 C) for at least 12 hours prior to organ recovery. Right Kidney will receive machine perfusion prior to implantation and the Left Kidney will receive cold storage.~Recovered kidneys will be placed in University of Wisconsin for cold storage until reimplantation."

OTHER

Pump Eligible - Hypothermia and Pump Left Kidney

Deceased Donors will be kept mildly hypothermic (34-35 C) for at least 12 hours prior to organ recovery. Left Kidney will receive machine perfusion prior to implantation and the Right Kidney will receive cold storage.

OTHER

Not Pump Eligible - Normothermia

"Deceased Donors will be kept normothermic (36.5-37.5 C) prior to organ recovery.~Pulsatile Perfusion of kidney grafts based on the respective OPO's protocol"

OTHER

Not Pump Eligible - Hypothermia

Deceased Donors will be kept mildly hypothermic (34-35 C) for at least 12 hours prior to organ recovery.

Trial Locations (7)

55411

LifeSource, Minneapolis

75231

Southwest Transplant Alliance, Dallas

77054

LifeGift, Houston

85013

Donor Network of Arizona, Phoenix

94143

U C San Francisco, San Francisco

97201

Pacific Northwest Transplant Bank, Portland

80246-1904

Donor Alliance, Denver

All Listed Sponsors
collaborator

Oregon Health and Science University

OTHER

lead

University of California, San Francisco

OTHER

NCT02525510 - Deceased Organ Donor Interventions to Protect Kidney Graft Function | Biotech Hunter | Biotech Hunter