Integrase and Maraviroc Intensification in Neurocognitive Dysfunction (InMIND)

PHASE4CompletedINTERVENTIONAL
Enrollment

191

Participants

Timeline

Start Date

April 21, 2016

Primary Completion Date

December 2, 2019

Study Completion Date

January 5, 2021

Conditions
HIV Infections
Interventions
DRUG

Placebo for maraviroc (MVC)

Administered orally as one 150 mg tablet BID OR two 300 mg tablet BID OR one 300 mg tablet BID depending upon background ARV regimen

DRUG

Placebo for dolutegravir (DTG)

Administered orally as one 50 mg tablet BID OR one 50 mg tablet QD depending upon background ARV regimen

DRUG

Dolutegravir (DTG)

Administered orally as one 50 mg tablet BID OR one 50 mg tablet QD depending upon background ARV regimen

DRUG

Maraviroc (MVC)

Administered orally as one 150 mg tablet BID OR two 300 mg tablet BID OR one 300 mg tablet BID depending upon background ARV regimen

Trial Locations (30)

2092

Wits Helen Joseph Hospital CRS (Wits HJH CRS), Johannesburg

4052

Durban International Clinical Research Site CRS, Durban

7505

Famcru Crs, Tygerberg

10010

Weill Cornell Chelsea CRS, New York

10065

Weill Cornell Uptown CRS, New York

10330

Thai Red Cross AIDS Research Centre (TRC-ARC) CRS, Bangkok

14642

University of Rochester Adult HIV Therapeutic Strategies Network CRS, Rochester

15213

University of Pittsburgh CRS, Pittsburgh

19104

Penn Therapeutics, CRS, Philadelphia

20005

Whitman-Walker Health CRS, Washington D.C.

21205

Johns Hopkins University CRS, Baltimore

27401

Greensboro CRS, Greensboro

27599

Chapel Hill CRS, Chapel Hill

37204

Vanderbilt Therapeutics (VT) CRS, Nashville

43210

Ohio State University CRS, Columbus

44106

Case Clinical Research Site, Cleveland

45219

Cincinnati Clinical Research Site, Cincinnati

50200

Chiang Mai University HIV Treatment (CMU HIV Treatment) CRS, Chiang Mai

60611

Northwestern University CRS, Chicago

75208

Trinity Health and Wellness Center CRS, Dallas

77030

Houston AIDS Research Team CRS, Houston

90035

UCLA CARE Center CRS, Los Angeles

90502

Harbor-UCLA CRS, Torrance

92103

UCSD Antiviral Research Center CRS, San Diego

63110-1010

Washington University Therapeutics (WT) CRS, St Louis

07103

New Jersey Medical School Clinical Research Center CRS, Newark

02906

The Miriam Hospital Clinical Research Site (TMH CRS) CRS, Providence

98104-9929

University of Washington AIDS CRS, Seattle

21040-360

Instituto de Pesquisa Clinica Evandro Chagas (IPEC) CRS, Rio de Janeiro

00935

Puerto Rico AIDS Clinical Trials Unit CRS, San Juan

All Listed Sponsors
lead

National Institute of Allergy and Infectious Diseases (NIAID)

NIH

NCT02519777 - Integrase and Maraviroc Intensification in Neurocognitive Dysfunction (InMIND) | Biotech Hunter | Biotech Hunter