A Trial of Pessary and Progesterone for Preterm Prevention in Twin Gestation With a Short Cervix

PHASE3CompletedINTERVENTIONAL
Enrollment

437

Participants

Timeline

Start Date

November 13, 2015

Primary Completion Date

December 15, 2024

Study Completion Date

February 18, 2025

Conditions
Short Cervical Length
Interventions
DRUG

Vaginal progesterone

200mg micronized vaginal progesterone softgel capsule, daily from randomization to \< 35 wks

DRUG

Placebo

placebo softgel capsule, daily from randomization to \< 35 wks

DEVICE

Arabin Pessary

Placement management from randomization to \< 35 wks

Trial Locations (16)

10032

Columbia University, New York

15213

Magee Women's Hospital, Pittsburgh

19104

Hospital of the University of Pennsylvania, Philadelphia

27599

University of North Carolina - Chapel Hill, Chapel Hill

27710

Duke University, Durham

35294

University of Alabama - Birmingham, Birmingham

43210

Ohio State University, Columbus

44109

Case Western Reserve University, Cleveland

60611

Northwestern University-Prentice Hospital, Chicago

77030

University of Texas - Houston, Houston

77555

University of Texas - Galveston, Galveston

80045

University of Colorado, Denver

84132

University of Utah Medical Center, Salt Lake City

Unknown

The Regents of the University of California, San Francisco, San Francisco

Baylor College of Medicine, Houston

02905

Brown University, Providence

All Listed Sponsors
collaborator

Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)

NIH

lead

The George Washington University Biostatistics Center

OTHER

NCT02518594 - A Trial of Pessary and Progesterone for Preterm Prevention in Twin Gestation With a Short Cervix | Biotech Hunter | Biotech Hunter