1,000
Participants
Start Date
September 1, 2015
Primary Completion Date
January 1, 2024
Study Completion Date
January 1, 2024
Laparoscopy
After removing the gallbladder, Laparoscopic common bile duct exploration (LCBDE) was performed by one fulltime attending in laparoscopy in a routine fashion. Access from the opening of the anterior wall of common bile duct or from the dilated cystic duct was acceptable, removed stone(s) and irrigated the duct followed by choledochoscope detection simultaneously. Cholangiograms were also can be a alternative method to obtain stone clearance. If needed, all fluoroscopy was performed by the principal author in the presence of and concurrence with the ERCP endoscopist. Once the LCBDE was completed, the incision of the bile duct was sewed intermittently by absorbed threads, or ligated cystic duct. T-tube was acceptable if needed.
Endoscopy
Initially endoscopic retrograde cholangiopancreatography (ERCP) was performed by a fulltime attending and concurrence of the principal author in endoscopy. Patients randomized to ERCP+ LC group were scheduled to undergo the endoscopic procedure using fluoroscopy in the endoscopy center under moderate sedation (principally intravenous midazolam and meperidine) prior to the intended laparoscopy. Gastric intestinal atony during ERCP was routinely achieved using scopolamine butylbromide injection. Sphincterotomy (EST) and Endoscopic papillary balloon dilatation (EPBD) can be choose accordingly. The laparoscopic cholecystectomy was subsequently performed as soon as technically feasible following the ERCP in one month.
The First Hospital of Jilin University, Changchun
Xin Hua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai
Shandong jiaotong Hospital, Jinan
Tianjin Nankai Hospital, Tianjin
The First Affiliated Hospital, Zhejiang University, Hangzhou
Southwest Hospital of Third Military Medical University, Chongqing
Second Xiangya Hospital, Central South University, Changsha
Union hospital,Tongji medical collage,Huazhong University of science and technology, Wuhan
The first affiliated hospital of Xi 'an jiaotong university, Xi’an
The first hospital of Lanzhou University, Lanzhou
General Hospital of Ningxia Medical University, Yinchuan
The First Teaching Hospital of Xinjiang Medical University, Ürümqi
Hepatopancreatobiliary Surgery Institute of Gansu Province
OTHER