Ceritinib in Combination With Stereotactic Ablative Radiation Metastatic Lung Adenocarcinoma

PHASE2TerminatedINTERVENTIONAL
Enrollment

14

Participants

Timeline

Start Date

November 30, 2015

Primary Completion Date

May 29, 2020

Study Completion Date

May 29, 2021

Conditions
ALK-positive Non-small Cell Lung Cancer
Interventions
DRUG

Ceritinib

Patients will receive ceritinib at a dose of 750 mg (150 mg capsules times 5 capsules once a day) for 10 weeks. Patient will stop taking Ceritinib 72 hours before SABR radiation. The patient may start taking Ceritinib again 72 hours after radiation is complete. Patient will continue to take certinib for up to 8 months.

RADIATION

Stereotactic ablative body radiation

Patients will receive study drug for 10 weeks. They could get 1, 3 ,or 5 treatments on consecutive days with 18 hours between each treatment or every other day (doctor's determination).

Trial Locations (1)

75390

UT Southwestern Medical Center, Dallas

Sponsors

Collaborators (1)

All Listed Sponsors
collaborator

Novartis Pharmaceuticals

INDUSTRY

lead

University of Texas Southwestern Medical Center

OTHER