Study to Evaluate the Efficacy and Safety of Eribulin Mesylate in Combination With Pembrolizumab in Participants With Metastatic Triple-Negative Breast Cancer (mTNBC)

PHASE1/PHASE2CompletedINTERVENTIONAL
Enrollment

258

Participants

Timeline

Start Date

August 28, 2015

Primary Completion Date

July 31, 2019

Study Completion Date

April 6, 2021

Conditions
Breast Neoplasm
Interventions
DRUG

Eribulin Mesylate

Eribulin Mesylate will be administered as a 1.4 milligram per square meter (mg/m\^2) IV (intravenous) infusion on Day 1 and Day 8 of each 21-day cycle in the presence of clinical benefit until intercurrent illness, unacceptable toxicity, or disease progression occurs, or until the participant withdraws consent.

DRUG

Pembrolizumab

Pembrolizumab will be administered as a 200 milligram (mg) IV infusion on Day 1 of each 21-day cycle in the presence of clinical benefit until intercurrent illness, unacceptable toxicity, or disease progression occurs, or until the participant withdraws consent.

Trial Locations (22)

10032

Facility #1, New York

10065

Facility #2, New York

22601

Facility #1, Winchester

24153

Facility #1, Salem

33176

Facility #1, Miami

33401

Facility #1, West Palm Beach

37203

Facility #1, Nashville

37404

Facility #1, Chattanooga

53792

Facility #1, Madison

55407

Facility #1, Minneapolis

63110

Facility #1, St Louis

75090

Facility #1, Sherman

76104

Facility #1, Fort Worth

78217

Facility #1, San Antonio

78229

Facility #2, San Antonio

78731

Facility #1, Austin

80218

Facility #1, Denver

91010

Facility #1, Duarte

93105

Facility #1, Santa Barbara

02115

Facility #1, Boston

Facility #2, Boston

03756

Facility #1, Lebanon

All Listed Sponsors
collaborator

Merck Sharp & Dohme LLC

INDUSTRY

lead

Eisai Inc.

INDUSTRY

NCT02513472 - Study to Evaluate the Efficacy and Safety of Eribulin Mesylate in Combination With Pembrolizumab in Participants With Metastatic Triple-Negative Breast Cancer (mTNBC) | Biotech Hunter | Biotech Hunter