58
Participants
Start Date
August 20, 2015
Primary Completion Date
July 25, 2021
Study Completion Date
July 25, 2021
TMS
single TMS pulses at intensities in random order from 0 to 100% (increasing at 5% intervals) of stimulator output at a frequency of 0.1 Hz. Three pulses will be delivered at each intensity. MEPs will be recorded and their amplitudes will be plotted against the corresponding stimulation intensity. This curve will provide three significant parameters: (a) S50 intensity (intensity for which we get a MEP 50 % of its maximal size); (b) estimated resting motor threshold (RMT): the abscissa where the tangent to the slope crosses the x axis; and (c) the maximum MEP ( plateau value).
National Institutes of Health Clinical Center, Bethesda
National Institute of Neurological Disorders and Stroke (NINDS)
NIH