582
Participants
Start Date
May 3, 2016
Primary Completion Date
June 12, 2023
Study Completion Date
July 16, 2026
Cediranib
Given PO
Cediranib Maleate
Given PO
Computed Tomography
Undergo CT
Magnetic Resonance Imaging
Undergo MRI
Olaparib
Given PO
Paclitaxel
Given IV
Pegylated Liposomal Doxorubicin Hydrochloride
Given IV
Questionnaire Administration
Ancillary studies
Topotecan
Given IV
Topotecan Hydrochloride
Given IV
Laura and Isaac Perlmutter Cancer Center at NYU Langone, New York
Montefiore Medical Center-Einstein Campus, The Bronx
Dickstein Cancer Treatment Center, White Plains
State University of New York Downstate Medical Center, Brooklyn
Stony Brook University Medical Center, Stony Brook
Women's Cancer Care Associates LLC, Albany
State University of New York Upstate Medical University, Syracuse
Roswell Park Cancer Institute, Buffalo
University of Rochester, Rochester
Wexford Health and Wellness Pavilion, Wexford
West Penn Hospital, Pittsburgh
Sechler Family Cancer Center, Lebanon
UPMC Pinnacle Cancer Center/Community Osteopathic Campus, Harrisburg
Adams Cancer Center, Gettysburg
WellSpan Medical Oncology and Hematology, Hanover
WellSpan Health-York Hospital, York
Ephrata Cancer Center, Ephrata
Ephrata Community Hospital, Ephrata
UPMC Susquehanna, Williamsport
Geisinger Medical Center, Danville
Geisinger Medical Oncology-Lewisburg, Lewisburg
Saint Luke's University Hospital-Bethlehem Campus, Bethlehem
Guthrie Medical Group PC-Robert Packer Hospital, Sayre
Jefferson Abington Hospital, Abington
Bryn Mawr Hospital, Bryn Mawr
Asplundh Cancer Pavilion, Willow Grove
Lankenau Medical Center, Wynnewood
University of Pennsylvania/Abramson Cancer Center, Philadelphia
Paoli Memorial Hospital, Paoli
Reading Hospital, West Reading
Helen F Graham Cancer Center, Newark
Medical Oncology Hematology Consultants PA, Newark
Christiana Care Health System-Christiana Hospital, Newark
Sibley Memorial Hospital, Washington D.C.
National Institutes of Health Clinical Center, Bethesda
UM Upper Chesapeake Medical Center, Bel Air
Greater Baltimore Medical Center, Baltimore
MedStar Franklin Square Medical Center/Weinberg Cancer Institute, Baltimore
Johns Hopkins University/Sidney Kimmel Cancer Center, Baltimore
TidalHealth Peninsula Regional, Salisbury
TidalHealth Richard A Henson Cancer Institute, Ocean Pines
University of Virginia Cancer Center, Charlottesville
VCU Massey Cancer Center at Stony Point, Richmond
VCU Massey Comprehensive Cancer Center, Richmond
West Virginia University Charleston Division, Charleston
Edwards Comprehensive Cancer Center, Huntington
Monongalia Hospital, Morgantown
West Virginia University Healthcare, Morgantown
Wake Forest University Health Sciences, Winston-Salem
Southeastern Medical Oncology Center-Goldsboro, Goldsboro
UNC Lineberger Comprehensive Cancer Center, Chapel Hill
Duke Cancer Center Raleigh, Raleigh
Duke University Medical Center, Durham
FirstHealth of the Carolinas-Moore Regional Hospital, Pinehurst
Novant Health New Hanover Regional Medical Center, Wilmington
Southeastern Medical Oncology Center-Jacksonville, Jacksonville
AdventHealth Infusion Center Haywood, Clyde
Margaret R Pardee Memorial Hospital, Hendersonville
AdventHealth Hendersonville, Hendersonville
AdventHealth Infusion Center Asheville, Asheville
Spartanburg Medical Center, Spartanburg
Gibbs Cancer Center-Gaffney, Gaffney
SMC Center for Hematology Oncology Union, Union
Saint Francis Hospital, Greenville
Saint Francis Cancer Center, Greenville
AnMed Health Cancer Center, Anderson
Gibbs Cancer Center-Pelham, Greer
WellStar Health System Inc, Marietta
Wellstar Kennestone Hospital, Marietta
WellStar North Fulton Hospital, Roswell
WellStar Vinings Health Park, Smyrna
WellStar Cobb Hospital, Austell
Emory University Hospital Midtown, Atlanta
Piedmont Hospital, Atlanta
Emory University Hospital/Winship Cancer Institute, Atlanta
Northside Hospital, Atlanta
Augusta University Medical Center, Augusta
Memorial Health University Medical Center, Savannah
Lewis Cancer and Research Pavilion at Saint Joseph's/Candler, Savannah
University of Florida Health Science Center - Gainesville, Gainesville
Orlando Health Cancer Institute, Orlando
Mount Sinai Medical Center, Miami Beach
Sarasota Memorial Hospital, Sarasota
University of Alabama at Birmingham Cancer Center, Birmingham
Vanderbilt University/Ingram Cancer Center, Nashville
Ballad Health Cancer Care - Kingsport, Kingsport
Wellmont Holston Valley Hospital and Medical Center, Kingsport
Thompson Cancer Survival Center, Knoxville
Thompson Cancer Survival Center - West, Knoxville
University of Mississippi Medical Center, Jackson
University of Kentucky/Markey Cancer Center, Lexington
Saint Elizabeth Healthcare Edgewood, Edgewood
Keimyung University-Dongsan Medical Center, Dalseo-gu
Ohio State University Comprehensive Cancer Center, Columbus
Riverside Methodist Hospital, Columbus
The Mark H Zangmeister Center, Columbus
ProMedica Flower Hospital, Sylvania
ProMedica Toledo Hospital/Russell J Ebeid Children's Hospital, Toledo
MetroHealth Medical Center, Cleveland
Cleveland Clinic Cancer Center/Fairview Hospital, Cleveland
Hillcrest Hospital Cancer Center, Mayfield Heights
Cleveland Clinic Foundation, Cleveland
Cleveland Clinic Akron General, Akron
Aultman Health Foundation, Canton
University of Cincinnati Cancer Center-West Chester, West Chester
University of Cincinnati Cancer Center-UC Medical Center, Cincinnati
Good Samaritan Hospital - Cincinnati, Cincinnati
TriHealth Cancer Institute-Westside, Cincinnati
Grandview Hospital, Dayton
Wright-Patterson Medical Center, Wright-Patterson Air Force Base
Miami Valley Hospital South, Centerville
Orion Cancer Care, Findlay
Indiana University/Melvin and Bren Simon Cancer Center, Indianapolis
Ascension Saint Vincent Indianapolis Hospital, Indianapolis
Memorial Hospital of South Bend, South Bend
Parkview Regional Medical Center, Fort Wayne
Reid Health, Richmond
Henry Ford Macomb Hospital-Clinton Township, Clinton Township
Trinity Health Saint Joseph Mercy Hospital Ann Arbor, Ann Arbor
University of Michigan Comprehensive Cancer Center, Ann Arbor
Henry Ford Cancer Institute-Downriver, Brownstown
Wayne State University/Karmanos Cancer Institute, Detroit
Henry Ford Hospital, Detroit
Henry Ford West Bloomfield Hospital, West Bloomfield
Weisberg Cancer Treatment Center, Farmington Hills
Trinity Health Saint Joseph Mercy Oakland Hospital, Pontiac
University of Michigan Health - Sparrow Lansing, Lansing
West Michigan Cancer Center, Kalamazoo
Corewell Health Grand Rapids Hospitals - Butterworth Hospital, Grand Rapids
Munson Medical Center, Traverse City
OSF Saint Francis Hospital and Medical Group, Escanaba
Mercy Medical Center-West Lakes, West Des Moines
Iowa Methodist Medical Center, Des Moines
UI Health Care Mission Cancer and Blood - Des Moines Clinic, Des Moines
Mercy Medical Center - Des Moines, Des Moines
UI Health Care Mission Cancer and Blood - Laurel Clinic, Des Moines
Mercy Cancer Center-West Lakes, Clive
UI Health Care Mission Cancer and Blood - West Des Moines Clinic, Clive
Siouxland Regional Cancer Center, Sioux City
University of Iowa/Holden Comprehensive Cancer Center, Iowa City
Aurora Health Care Germantown Health Center, Germantown
Aurora Cancer Care-Grafton, Grafton
ProHealth Oconomowoc Memorial Hospital, Oconomowoc
Aurora Medical Center in Summit, Summit
Vince Lombardi Cancer Clinic-Sheboygan, Sheboygan
Ascension Columbia Saint Mary's Hospital Ozaukee, Mequon
Aurora Cancer Care-Southern Lakes VLCC, Burlington
Aurora Cancer Care-Kenosha South, Kenosha
ProHealth D N Greenwald Center, Mukwonago
ProHealth Waukesha Memorial Hospital, Waukesha
UW Cancer Center at ProHealth Care, Waukesha
Aurora Cancer Care-Milwaukee, Milwaukee
Ascension Columbia Saint Mary's Hospital - Milwaukee, Milwaukee
Aurora Saint Luke's Medical Center, Milwaukee
Medical College of Wisconsin, Milwaukee
Aurora Cancer Care-Milwaukee West, Wauwatosa
Aurora West Allis Medical Center, West Allis
Aurora Sinai Medical Center, Milwaukee
Aurora Cancer Care-Racine, Racine
University of Wisconsin Carbone Cancer Center - University Hospital, Madison
Aurora Bay Area Medical Group-Marinette, Marinette
Saint Vincent Hospital Cancer Center at Marinette, Marinette
Saint Vincent Hospital Cancer Center at Oconto Falls, Oconto Falls
Vince Lombardi Cancer Clinic-Two Rivers, Two Rivers
Saint Vincent Hospital Cancer Center Green Bay, Green Bay
Saint Vincent Hospital Cancer Center at Saint Mary's, Green Bay
Aurora BayCare Medical Center, Green Bay
Marshfield Clinic-Wausau Center, Wausau
Marshfield Medical Center-Marshfield, Marshfield
Marshfield Medical Center - Weston, Weston
Aspirus Cancer Care - Stevens Point, Stevens Point
Marshfield Medical Center-River Region at Stevens Point, Stevens Point
Marshfield Clinic - Wisconsin Rapids Center, Wisconsin Rapids
Marshfield Medical Center - Minocqua, Minocqua
Gundersen Lutheran Medical Center, La Crosse
Marshfield Clinic Cancer Center at Sacred Heart, Eau Claire
Marshfield Clinic-Chippewa Center, Chippewa Falls
Marshfield Medical Center - Ladysmith, Ladysmith
Marshfield Medical Center-Rice Lake, Rice Lake
Ascension Mercy Hospital, Oshkosh
Vince Lombardi Cancer Clinic - Oshkosh, Oshkosh
Ascension Saint Elizabeth Hospital, Appleton
Aurora Health Center-Fond du Lac, Fond du Lac
Regions Hospital, Saint Paul
United Hospital, Saint Paul
Saint John's Hospital - Healtheast, Maplewood
Minnesota Oncology Hematology PA-Woodbury, Woodbury
Fairview Ridges Hospital, Burnsville
Fairview Clinics and Surgery Center Maple Grove, Maple Grove
Saint Francis Regional Medical Center, Shakopee
Abbott-Northwestern Hospital, Minneapolis
Park Nicollet Clinic - Saint Louis Park, Saint Louis Park
Mercy Hospital, Coon Rapids
Fairview Southdale Hospital, Edina
University of Minnesota/Masonic Cancer Center, Minneapolis
Mayo Clinic in Rochester, Rochester
Mayo Clinic Health Systems-Mankato, Mankato
Sanford Joe Lueken Cancer Center, Bemidji
Sanford Cancer Center Oncology Clinic, Sioux Falls
Avera Cancer Institute, Sioux Falls
Rapid City Regional Hospital, Rapid City
Sanford Broadway Medical Center, Fargo
Sanford Roger Maris Cancer Center, Fargo
Sanford Bismarck Medical Center, Bismarck
Billings Clinic Cancer Center, Billings
Benefis Sletten Cancer Institute, Great Falls
Bozeman Health Deaconess Hospital, Bozeman
NorthShore University HealthSystem-Glenbrook Hospital, Glenview
NorthShore University HealthSystem-Highland Park Hospital, Highland Park
Midwestern Regional Medical Center, Zion
Northwestern Medicine Cancer Center Delnor, Geneva
NorthShore University HealthSystem-Evanston Hospital, Evanston
Rush-Copley Medical Center, Aurora
Sudarshan K Sharma MD Limited-Gynecologic Oncology, Hinsdale
Northwestern Medicine Cancer Center Warrenville, Warrenville
Northwestern University, Chicago
John H Stroger Jr Hospital of Cook County, Chicago
Rush University Medical Center, Chicago
UChicago Medicine Comprehensive Cancer Center - Saint Joseph Hospital, Chicago
Illinois CancerCare-Ottawa Clinic, Ottawa
Illinois CancerCare-Peru, Peru
Illinois CancerCare-Princeton, Princeton
Illinois CancerCare-Galesburg, Galesburg
Illinois CancerCare-Kewanee Clinic, Kewanee
Illinois CancerCare-Macomb, Macomb
Illinois CancerCare-Canton, Canton
Illinois CancerCare-Eureka, Eureka
Illinois CancerCare-Pekin, Pekin
Illinois CancerCare-Peoria, Peoria
Illinois CancerCare-Bloomington, Bloomington
Cancer Care Center of O'Fallon, O'Fallon
Illinois CancerCare-Carthage, Carthage
Crossroads Cancer Center, Effingham
Cancer Care Specialists of Illinois - Decatur, Decatur
Decatur Memorial Hospital, Decatur
Springfield Clinic, Springfield
Springfield Memorial Hospital, Springfield
Centralia Oncology Clinic, Centralia
Barnes-Jewish Hospital, St Louis
Washington University School of Medicine, St Louis
Saint Francis Medical Center, Cape Girardeau
Mercy Hospital Joplin, Joplin
MU Health - University Hospital/Ellis Fischel Cancer Center, Columbia
Mercy Hospital Springfield, Springfield
CoxHealth South Hospital, Springfield
Associates In Womens Health, Wichita
Ascension Via Christi Hospitals Wichita, Wichita
Nebraska Methodist Hospital, Omaha
Alegent Health Bergan Mercy Medical Center, Omaha
Alegent Health Lakeside Hospital, Omaha
Nebraska Cancer Specialists/Oncology Hematology West PC, Grand Island
CHI Health Good Samaritan, Kearney
Ochsner Medical Center Jefferson, New Orleans
Women's Cancer Care-Covington, Covington
Hematology/Oncology Clinic PLLC, Baton Rouge
Mary Bird Perkins Cancer Center, Baton Rouge
Woman's Hospital, Baton Rouge
University of Arkansas for Medical Sciences, Little Rock
University of Oklahoma Health Sciences Center, Oklahoma City
Cancer Treatment Centers of America, Tulsa
Oklahoma Cancer Specialists and Research Institute-Tulsa, Tulsa
Parkland Memorial Hospital, Dallas
UT Southwestern/Simmons Cancer Center-Dallas, Dallas
Houston Methodist Hospital, Houston
Methodist Willowbrook Hospital, Houston
Houston Methodist Sugar Land Hospital, Sugar Land
Kaiser Permanente-Rock Creek, Lafayette
UCHealth University of Colorado Hospital, Aurora
Kaiser Permanente-Lone Tree, Lone Tree
UCHealth Highlands Ranch Hospital, Highlands Ranch
Kaiser Permanente-Franklin, Denver
Rocky Mountain Cancer Centers-Rose, Denver
Poudre Valley Hospital, Fort Collins
Penrose-Saint Francis Healthcare, Colorado Springs
UCHealth Memorial Hospital Central, Colorado Springs
Saint Luke's Cancer Institute - Fruitland, Fruitland
Saint Luke's Cancer Institute - Meridian, Meridian
Saint Luke's Cancer Institute - Nampa, Nampa
Saint Alphonsus Cancer Care Center-Boise, Boise
Saint Luke's Cancer Institute - Boise, Boise
South Jordan Health Center, South Jordan
Utah Cancer Specialists-Salt Lake City, Salt Lake City
Intermountain Medical Center, Murray
Huntsman Cancer Institute/University of Utah, Salt Lake City
Saint George Regional Medical Center, St. George
Southwest Gynecologic Oncology Associates Inc, Albuquerque
University of New Mexico Cancer Center, Albuquerque
Memorial Medical Center-Las Cruces, Las Cruces
Women's Cancer Center of Nevada, Las Vegas
UC San Diego Moores Cancer Center, La Jolla
Pacific Central Coast Health Center-San Luis Obispo, San Luis Obispo
Palo Alto Medical Foundation-Camino Division, Mountain View
Palo Alto Medical Foundation-Gynecologic Oncology, Mountain View
Palo Alto Medical Foundation-Sunnyvale, Sunnyvale
California Pacific Medical Center-Pacific Campus, San Francisco
Kaiser Permanente-San Francisco, San Francisco
UCSF Medical Center-Mission Bay, San Francisco
Palo Alto Medical Foundation Health Care, Palo Alto
Kaiser Permanente-Vallejo, Vallejo
Kaiser Permanente-Walnut Creek, Walnut Creek
Kaiser Permanente-Oakland, Oakland
Alta Bates Summit Medical Center-Herrick Campus, Berkeley
Marin Cancer Care Inc, Greenbrae
Kaiser Permanente Medical Center - Santa Clara, Santa Clara
Palo Alto Medical Foundation-Santa Cruz, Santa Cruz
Sutter Pacific Medical Foundation, Santa Rosa
Sutter Auburn Faith Hospital, Auburn
Mercy San Juan Medical Center, Carmichael
Sutter Roseville Medical Center, Roseville
Woodland Memorial Hospital, Woodland
Mercy Cancer Center - Elk Grove, Elk Grove
Mercy Cancer Center - Rocklin, Rocklin
Kaiser Permanente Downtown Commons, Sacramento
Mercy Cancer Center - Sacramento, Sacramento
Sutter Medical Center Sacramento, Sacramento
University of California Davis Comprehensive Cancer Center, Sacramento
Kaiser Permanente Sacramento Medical Center, Sacramento
Queen's Medical Center, Honolulu
Kapiolani Medical Center for Women and Children, Honolulu
Legacy Mount Hood Medical Center, Gresham
Legacy Meridian Park Hospital, Tualatin
Legacy Good Samaritan Hospital and Medical Center, Portland
Saint Charles Health System, Bend
Swedish Cancer Institute-Edmonds, Edmonds
Pacific Gynecology Specialists, Seattle
Fred Hutchinson Cancer Center, Seattle
Swedish Medical Center-First Hill, Seattle
University of Washington Medical Center - Northwest, Seattle
Women's Cancer Center of Seattle, Seattle
University of Washington Medical Center - Montlake, Seattle
PeaceHealth Saint Joseph Medical Center, Bellingham
Skagit Regional Health Cancer Care Center, Mount Vernon
Skagit Valley Hospital, Mount Vernon
Legacy Salmon Creek Hospital, Vancouver
Wenatchee Valley Hospital and Clinics, Wenatchee
Kadlec Clinic Hematology and Oncology, Kennewick
Alaska Women's Cancer Care, Anchorage
Providence Alaska Medical Center, Anchorage
Danbury Hospital, Danbury
Smilow Cancer Hospital Care Center-Fairfield, Fairfield
Hartford Hospital, Hartford
Smilow Cancer Hospital Care Center at Saint Francis, Hartford
Middlesex Hospital, Middletown
The Hospital of Central Connecticut, New Britain
Yale University, New Haven
Norwalk Hospital, Norwalk
Smilow Cancer Hospital Care Center-Trumbull, Trumbull
Eastern Maine Medical Center, Bangor
Lafayette Family Cancer Center-EMMC, Brewer
MaineHealth Maine Medical Center- Scarborough, Scarborough
Brigham and Women's Hospital, Boston
Dana-Farber Cancer Institute, Boston
UMass Memorial Medical Center - Memorial Division, Worcester
Dartmouth Hitchcock Medical Center/Dartmouth Cancer Center, Lebanon
Dartmouth Cancer Center - Nashua, Nashua
Cooper Hospital University Medical Center, Camden
Hackensack University Medical Center, Hackensack
The Cancer Institute of New Jersey Hamilton, Hamilton
Morristown Medical Center, Morristown
Jersey Shore Medical Center, Neptune City
Rutgers Cancer Institute of New Jersey, New Brunswick
Robert Wood Johnson University Hospital Somerset, Somerville
Overlook Hospital, Summit
MD Anderson Cancer Center at Cooper-Voorhees, Voorhees Township
Women and Infants Hospital, Providence
South Carolina Cancer Specialists PC, Hilton Head Island
Sanford USD Medical Center - Sioux Falls, Sioux Falls
Central Vermont Medical Center/National Life Cancer Treatment, Berlin Corners
University of Vermont Medical Center, Burlington
University of Vermont and State Agricultural College, Burlington
Saint Vincent Hospital Cancer Center at Sturgeon Bay, Sturgeon Bay
Arthur J E Child Comprehensive Cancer Centre, Calgary
Cross Cancer Institute, Edmonton
Royal Victoria Regional Health Centre, Barrie
Juravinski Cancer Centre at Hamilton Health Sciences, Hamilton
Kingston Health Sciences Centre, Kingston
London Regional Cancer Program, London
Algoma District Cancer Program Sault Area Hospital, Sault Ste. Marie
Odette Cancer Centre- Sunnybrook Health Sciences Centre, Toronto
University Health Network-Princess Margaret Hospital, Toronto
CIUSSSEMTL-Hopital Maisonneuve-Rosemont, Montreal
CHUM - Centre Hospitalier de l'Universite de Montreal, Montreal
Jewish General Hospital, Montreal
CHU de Quebec-L'Hotel-Dieu de Quebec (HDQ), Québec
Ehime University Hospital, Tōon
Hokkaido University Hospital, Sapporo
Kagoshima City Hospital, Kagoshima
The Cancer Institute Hospital Of JFCR, Koto-ku
Kindai University, Osaka
Saitama Medical University International Medical Center, Saitama
National Cancer Center Hospital, Tokyo
Centro Comprensivo de Cancer de UPR, San Juan
Seoul National University Bundang Hospital, Seongnam
Gachon University Gil Hospital, Incheon
Asan Medical Center, Seoul
Gangnam Severance Hospital, Seoul
Kyung Hee University Hospital at Gangdong, Seoul
Korea Cancer Center Hospital, Seoul
Collaborators (1)
Canadian Cancer Trials Group
NETWORK
NRG Oncology
OTHER
National Cancer Institute (NCI)
NIH